Mitochondrial dysfunction associated with glucocerebrosidase deficiency

Mitochondrial dysfunction associated with glucocerebrosidase deficiency

The lysosomal hydrolase glucocerebrosidase (GCase) is encoded for by the GBA gene. Homozygous GBA mutations cause Gaucher disease (GD), a lysosomal storage disorder. Furthermore, homozygous and heterozygous GBA mutations are numerically the greatest genetic risk factor for developing Parkinson'...

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Bibliographic Details
Main Authors: Matthew E. Gegg, Anthony H.V. Schapira
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Neurobiology of Disease
Subjects:
Autophagy
Gaucher disease
Glucocerebrosidase
Lysosome
Mitochondria
mitophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611530053X

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http://www.sciencedirect.com/science/article/pii/S096999611530053X

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