Bone mineral density, adiposity and cognitive functions
Cognitive decline and dementia due to Alzheimer’s disease have been associated with genetic, lifestyle, and environmental factors. A number of potentially modifiable risk factors should be taken into account when preventive or ameliorative interventions targeting dementia and its preclinical stages...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00016/full |
| _version_ | 1818844655406546944 |
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| author | Hamid R Sohrabi Hamid R Sohrabi Kristyn A Bates Michael eWeinborn Michael eWeinborn Romola S Bucks Stephanie R Rainey-Smith Stephanie R Rainey-Smith Mark A Rodrigues Sabine M Bird Belinda M Brown Belinda M Brown John eBeilby John eBeilby Matthew eHoward Arthur eCriddle Megan eWraith Kevin eTaddei Kevin eTaddei Georgia eMartins Athena ePaton Tejal eShah Satvinder S Dhaliwal Pankaj D Mehta Jonathan K Foster Ian J Martins Nicola T Lautenschlager Nicola T Lautenschlager Francis eMastaglia Simon M Laws Ralph N Martins Ralph N Martins |
| author_facet | Hamid R Sohrabi Hamid R Sohrabi Kristyn A Bates Michael eWeinborn Michael eWeinborn Romola S Bucks Stephanie R Rainey-Smith Stephanie R Rainey-Smith Mark A Rodrigues Sabine M Bird Belinda M Brown Belinda M Brown John eBeilby John eBeilby Matthew eHoward Arthur eCriddle Megan eWraith Kevin eTaddei Kevin eTaddei Georgia eMartins Athena ePaton Tejal eShah Satvinder S Dhaliwal Pankaj D Mehta Jonathan K Foster Ian J Martins Nicola T Lautenschlager Nicola T Lautenschlager Francis eMastaglia Simon M Laws Ralph N Martins Ralph N Martins |
| author_sort | Hamid R Sohrabi |
| collection | DOAJ |
| description | Cognitive decline and dementia due to Alzheimer’s disease have been associated with genetic, lifestyle, and environmental factors. A number of potentially modifiable risk factors should be taken into account when preventive or ameliorative interventions targeting dementia and its preclinical stages are investigated. Bone mineral density (BMD) and body composition are two such potentially modifiable risk factors, and their association with cognitive decline was investigated in this study. 164 participants, aged 34 to 87 years old (62.78±9.27), were recruited for this longitudinal study and underwent cognitive and clinical examinations at baseline and after three years. Blood samples were collected for apolipoprotein E (APOE) genotyping and dual energy x-ray absorptiometry (DXA) was conducted at the same day as cognitive assessment. Using hierarchical regression analysis, we found that BMD and lean body mass, as measured using DXA were significant predictors of episodic memory. Age, gender, APOE status and premorbid IQ were controlled for. Specifically, the List A learning from California Verbal Learning Test was significantly associated with BMD and lean mass both at baseline and at follow up assessment. Our findings indicate that there is a significant association between BMD and lean body mass and episodic verbal learning. While the involvement of modifiable lifestyle factors in human cognitive function has been examined in different studies, there is a need for further research to understand the potential underlying mechanisms. |
| first_indexed | 2024-12-19T05:17:13Z |
| format | Article |
| id | doaj.art-96ba035a4f1e406a969e581541d55131 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-19T05:17:13Z |
| publishDate | 2015-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-96ba035a4f1e406a969e581541d551312022-12-21T20:34:38ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-02-01710.3389/fnagi.2015.00016126977Bone mineral density, adiposity and cognitive functionsHamid R Sohrabi0Hamid R Sohrabi1Kristyn A Bates2Michael eWeinborn3Michael eWeinborn4Romola S Bucks5Stephanie R Rainey-Smith6Stephanie R Rainey-Smith7Mark A Rodrigues8Sabine M Bird9Belinda M Brown10Belinda M Brown11John eBeilby12John eBeilby13Matthew eHoward14Arthur eCriddle15Megan eWraith16Kevin eTaddei17Kevin eTaddei18Georgia eMartins19Athena ePaton20Tejal eShah21Satvinder S Dhaliwal22Pankaj D Mehta23Jonathan K Foster24Ian J Martins25Nicola T Lautenschlager26Nicola T Lautenschlager27Francis eMastaglia28Simon M Laws29Ralph N Martins30Ralph N Martins31Edith Cowan UniversityMcCusker Alzheimer's Research FoundationUniversity of Western AustraliaUniversity of Western AustraliaMcCusker Alzheimer's Research FoundationUniversity of Western AustraliaEdith Cowan UniversityMcCusker Alzheimer's Research FoundationEdith Cowan UniversityEdith Cowan UniversityEdith Cowan UniversityMcCusker Alzheimer's Research FoundationUnviversity of Western AustraliaPathWest Laboratory Medicine of WACalibre Global Pty LtdWestern Medicine, Hollywood Specialist CentreWestern Medicine, Hollywood Specialist CentreEdith Cowan UniversityMcCusker Alzheimer's Research FoundationEdith Cowan UniversityMcCusker Alzheimer's Research FoundationMcCusker Alzheimer's Research FoundationCurtin University of TechnologyInstitute for Basic Research in Developmental DisabilitiesCurtin University of TechnologyEdith Cowan UniversityUniversity of MelbourneUniversity of Western AustraliaMurdoch UniversityEdith Cowan UniversityEdith Cowan UniversityMcCusker Alzheimer's Research FoundationCognitive decline and dementia due to Alzheimer’s disease have been associated with genetic, lifestyle, and environmental factors. A number of potentially modifiable risk factors should be taken into account when preventive or ameliorative interventions targeting dementia and its preclinical stages are investigated. Bone mineral density (BMD) and body composition are two such potentially modifiable risk factors, and their association with cognitive decline was investigated in this study. 164 participants, aged 34 to 87 years old (62.78±9.27), were recruited for this longitudinal study and underwent cognitive and clinical examinations at baseline and after three years. Blood samples were collected for apolipoprotein E (APOE) genotyping and dual energy x-ray absorptiometry (DXA) was conducted at the same day as cognitive assessment. Using hierarchical regression analysis, we found that BMD and lean body mass, as measured using DXA were significant predictors of episodic memory. Age, gender, APOE status and premorbid IQ were controlled for. Specifically, the List A learning from California Verbal Learning Test was significantly associated with BMD and lean mass both at baseline and at follow up assessment. Our findings indicate that there is a significant association between BMD and lean body mass and episodic verbal learning. While the involvement of modifiable lifestyle factors in human cognitive function has been examined in different studies, there is a need for further research to understand the potential underlying mechanisms.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00016/fullCognitionExecutive FunctionAgeingApolipoprotein Ebone mineral densityDual energy X-ray absorptiometry |
| spellingShingle | Hamid R Sohrabi Hamid R Sohrabi Kristyn A Bates Michael eWeinborn Michael eWeinborn Romola S Bucks Stephanie R Rainey-Smith Stephanie R Rainey-Smith Mark A Rodrigues Sabine M Bird Belinda M Brown Belinda M Brown John eBeilby John eBeilby Matthew eHoward Arthur eCriddle Megan eWraith Kevin eTaddei Kevin eTaddei Georgia eMartins Athena ePaton Tejal eShah Satvinder S Dhaliwal Pankaj D Mehta Jonathan K Foster Ian J Martins Nicola T Lautenschlager Nicola T Lautenschlager Francis eMastaglia Simon M Laws Ralph N Martins Ralph N Martins Bone mineral density, adiposity and cognitive functions Frontiers in Aging Neuroscience Cognition Executive Function Ageing Apolipoprotein E bone mineral density Dual energy X-ray absorptiometry |
| title | Bone mineral density, adiposity and cognitive functions |
| title_full | Bone mineral density, adiposity and cognitive functions |
| title_fullStr | Bone mineral density, adiposity and cognitive functions |
| title_full_unstemmed | Bone mineral density, adiposity and cognitive functions |
| title_short | Bone mineral density, adiposity and cognitive functions |
| title_sort | bone mineral density adiposity and cognitive functions |
| topic | Cognition Executive Function Ageing Apolipoprotein E bone mineral density Dual energy X-ray absorptiometry |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00016/full |
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