Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip.
<h4>Background</h4>Cleft lip is the most common congenital anomaly worldwide. Nevertheless, lip somatosensory characteristics of patients with cleft lip after cheiloplasty have not yet been determined. The present study used magnetoencephalography to objectively evaluate the lip sensatio...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0274405 |
| _version_ | 1818030022469877760 |
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| author | Chihiro Kitayama Eriya Shimada Hiroki Hihara Akitake Kanno Nobukazu Nakasato Yoshimichi Imai Akimitsu Sato Ryuta Kawashima Kaoru Igarashi Hiroyasu Kanetaka |
| author_facet | Chihiro Kitayama Eriya Shimada Hiroki Hihara Akitake Kanno Nobukazu Nakasato Yoshimichi Imai Akimitsu Sato Ryuta Kawashima Kaoru Igarashi Hiroyasu Kanetaka |
| author_sort | Chihiro Kitayama |
| collection | DOAJ |
| description | <h4>Background</h4>Cleft lip is the most common congenital anomaly worldwide. Nevertheless, lip somatosensory characteristics of patients with cleft lip after cheiloplasty have not yet been determined. The present study used magnetoencephalography to objectively evaluate the lip sensation in patients with unilateral cleft lip to establish a new objective evaluation method.<h4>Methods</h4>Participants were 15 patients with unilateral cleft lip after cheiloplasty (UCL group), and 30 healthy young subjects (control group). Five points of the upper and lower lips were stimulated electrically to measure somatosensory evoked magnetic fields (SEFs). The sources of the magnetic fields were modeled as single equivalent current dipoles (ECDs). ECDs located on the central sulcus by superimposition on magnetic resonance images were analyzed. Latency and intensity at 50-75 ms (cP60m) observed in the UCL group were compared with those in the control group. Thresholds of tactile stimuli in both groups were obtained using Semmes-Weinstein monofilaments for subjective sensory evaluation.<h4>Results</h4>No significant difference was found in the intensity of the cP60m or subjective evaluation between the groups. However, the latency of the cP60m was significantly longer in the upper lip of the UCL group than in the control group.<h4>Conclusions</h4>SEFs showed a difference in lip sensation between the UCL group and the control group, suggesting that longer latency might be caused by the effects of surgical scarring on the neurotransmission pathway. These results suggest SEFs as useful for the objective evaluation of lip sensations. This study might improve future surgical procedures and lip functions of patients with cleft lip. |
| first_indexed | 2024-12-10T05:28:58Z |
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| id | doaj.art-96bb2c3df76b42e2a15c43ea6361cc40 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T05:28:58Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-96bb2c3df76b42e2a15c43ea6361cc402022-12-22T02:00:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179e027440510.1371/journal.pone.0274405Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip.Chihiro KitayamaEriya ShimadaHiroki HiharaAkitake KannoNobukazu NakasatoYoshimichi ImaiAkimitsu SatoRyuta KawashimaKaoru IgarashiHiroyasu Kanetaka<h4>Background</h4>Cleft lip is the most common congenital anomaly worldwide. Nevertheless, lip somatosensory characteristics of patients with cleft lip after cheiloplasty have not yet been determined. The present study used magnetoencephalography to objectively evaluate the lip sensation in patients with unilateral cleft lip to establish a new objective evaluation method.<h4>Methods</h4>Participants were 15 patients with unilateral cleft lip after cheiloplasty (UCL group), and 30 healthy young subjects (control group). Five points of the upper and lower lips were stimulated electrically to measure somatosensory evoked magnetic fields (SEFs). The sources of the magnetic fields were modeled as single equivalent current dipoles (ECDs). ECDs located on the central sulcus by superimposition on magnetic resonance images were analyzed. Latency and intensity at 50-75 ms (cP60m) observed in the UCL group were compared with those in the control group. Thresholds of tactile stimuli in both groups were obtained using Semmes-Weinstein monofilaments for subjective sensory evaluation.<h4>Results</h4>No significant difference was found in the intensity of the cP60m or subjective evaluation between the groups. However, the latency of the cP60m was significantly longer in the upper lip of the UCL group than in the control group.<h4>Conclusions</h4>SEFs showed a difference in lip sensation between the UCL group and the control group, suggesting that longer latency might be caused by the effects of surgical scarring on the neurotransmission pathway. These results suggest SEFs as useful for the objective evaluation of lip sensations. This study might improve future surgical procedures and lip functions of patients with cleft lip.https://doi.org/10.1371/journal.pone.0274405 |
| spellingShingle | Chihiro Kitayama Eriya Shimada Hiroki Hihara Akitake Kanno Nobukazu Nakasato Yoshimichi Imai Akimitsu Sato Ryuta Kawashima Kaoru Igarashi Hiroyasu Kanetaka Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip. PLoS ONE |
| title | Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip. |
| title_full | Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip. |
| title_fullStr | Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip. |
| title_full_unstemmed | Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip. |
| title_short | Magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip. |
| title_sort | magnetoencephalographic evaluation of repaired lip sensation in patients with cleft lip |
| url | https://doi.org/10.1371/journal.pone.0274405 |
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