Targeted sampling reduces the uncertainty in force of infection estimates from serological surveillance
Age bins are frequently used in serological studies of infectious diseases in wildlife to deal with uncertainty in the age of sampled animals. This study analyzed how age binning and targeted sampling in serological surveillance affect the width of the 95% confidence interval (CI) of the estimated f...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.754255/full |
| _version_ | 1818162473730048000 |
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| author | Kiyeon Kim Kimihito Ito |
| author_facet | Kiyeon Kim Kimihito Ito |
| author_sort | Kiyeon Kim |
| collection | DOAJ |
| description | Age bins are frequently used in serological studies of infectious diseases in wildlife to deal with uncertainty in the age of sampled animals. This study analyzed how age binning and targeted sampling in serological surveillance affect the width of the 95% confidence interval (CI) of the estimated force of infection (FOI) of infectious diseases. We indicate that the optimal target population with the narrowest 95% CI differs depending on the expected FOI using computer simulations and mathematical models. In addition, our findings show that we can substantially reduce the number of animals required to infer transmission risk by tailoring targeted, age-based sampling to specific epidemiological situations. |
| first_indexed | 2024-12-11T16:34:14Z |
| format | Article |
| id | doaj.art-96bcc8acde244dc69fa4de2ff6038e6b |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-11T16:34:14Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-96bcc8acde244dc69fa4de2ff6038e6b2022-12-22T00:58:30ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-07-01910.3389/fvets.2022.754255754255Targeted sampling reduces the uncertainty in force of infection estimates from serological surveillanceKiyeon KimKimihito ItoAge bins are frequently used in serological studies of infectious diseases in wildlife to deal with uncertainty in the age of sampled animals. This study analyzed how age binning and targeted sampling in serological surveillance affect the width of the 95% confidence interval (CI) of the estimated force of infection (FOI) of infectious diseases. We indicate that the optimal target population with the narrowest 95% CI differs depending on the expected FOI using computer simulations and mathematical models. In addition, our findings show that we can substantially reduce the number of animals required to infer transmission risk by tailoring targeted, age-based sampling to specific epidemiological situations.https://www.frontiersin.org/articles/10.3389/fvets.2022.754255/fullserological surveillancewildlifecatalytic modelforce of infectionconfidence intervalstargeted sampling |
| spellingShingle | Kiyeon Kim Kimihito Ito Targeted sampling reduces the uncertainty in force of infection estimates from serological surveillance Frontiers in Veterinary Science serological surveillance wildlife catalytic model force of infection confidence intervals targeted sampling |
| title | Targeted sampling reduces the uncertainty in force of infection estimates from serological surveillance |
| title_full | Targeted sampling reduces the uncertainty in force of infection estimates from serological surveillance |
| title_fullStr | Targeted sampling reduces the uncertainty in force of infection estimates from serological surveillance |
| title_full_unstemmed | Targeted sampling reduces the uncertainty in force of infection estimates from serological surveillance |
| title_short | Targeted sampling reduces the uncertainty in force of infection estimates from serological surveillance |
| title_sort | targeted sampling reduces the uncertainty in force of infection estimates from serological surveillance |
| topic | serological surveillance wildlife catalytic model force of infection confidence intervals targeted sampling |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.754255/full |
| work_keys_str_mv | AT kiyeonkim targetedsamplingreducestheuncertaintyinforceofinfectionestimatesfromserologicalsurveillance AT kimihitoito targetedsamplingreducestheuncertaintyinforceofinfectionestimatesfromserologicalsurveillance |