Web-based Application for the Population Pharmacokinetic Service (WAPPS)'s impact on dosage selection: a single paediatric centre experience
Current treatment for severe haemophilia includes prophylactic factor replacement to prevent bleeding. Coagulation factor products have significant inter-patient variability in pharmacokinetic (PK) parameters. Optimal management requires tailoring prophylaxis to individual PK parameters. Web-based A...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2021-07-01
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| Series: | The Journal of Haemophilia Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.17225/jhp00179 |
| _version_ | 1797832435589709824 |
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| author | Kwan Celia Bhatt Mihir D. Strike Karen Decker Kay Matino Davide Chan Anthony K.C. |
| author_facet | Kwan Celia Bhatt Mihir D. Strike Karen Decker Kay Matino Davide Chan Anthony K.C. |
| author_sort | Kwan Celia |
| collection | DOAJ |
| description | Current treatment for severe haemophilia includes prophylactic factor replacement to prevent bleeding. Coagulation factor products have significant inter-patient variability in pharmacokinetic (PK) parameters. Optimal management requires tailoring prophylaxis to individual PK parameters. Web-based Application for the Population Pharmacokinetic Service (WAPPS) is a tool that estimates individual PK values using a population approach. Despite its growing use to help guide dosing selection, few studies have investigated its clinical impact. |
| first_indexed | 2024-04-09T14:07:45Z |
| format | Article |
| id | doaj.art-96bd59a36bfe41e88a903d4ea59125bb |
| institution | Directory Open Access Journal |
| issn | 2055-3390 |
| language | English |
| last_indexed | 2024-04-09T14:07:45Z |
| publishDate | 2021-07-01 |
| publisher | Sciendo |
| record_format | Article |
| series | The Journal of Haemophilia Practice |
| spelling | doaj.art-96bd59a36bfe41e88a903d4ea59125bb2023-05-06T15:59:46ZengSciendoThe Journal of Haemophilia Practice2055-33902021-07-0181808510.17225/jhp00179Web-based Application for the Population Pharmacokinetic Service (WAPPS)'s impact on dosage selection: a single paediatric centre experienceKwan Celia0Bhatt Mihir D.1Strike Karen2Decker Kay3Matino Davide4Chan Anthony K.C.5Faculty of Medicine, University of British Columbia, Vancouver, BC, CanadaDepartment of Paediatrics, McMaster University, Hamilton, ON, Canada; Hamilton Niagara Regional Hemophilia Program, McMaster Children's Hospital, Hamilton Health Sciences, Hamilton, ON, CanadaHamilton Niagara Regional Hemophilia Program, McMaster Children's Hospital, Hamilton Health Sciences, Hamilton, ON, Canada; School of Rehabilitation Science, Faculty of Health Science, McMaster University, Hamilton, ON, CanadaHamilton Niagara Regional Hemophilia Program, McMaster Children's Hospital, Hamilton Health Sciences, Hamilton, ON, CanadaHamilton Niagara Regional Hemophilia Program, McMaster Children's Hospital, Hamilton Health Sciences, Hamilton, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, CanadaDepartment of Paediatrics, McMaster University, Hamilton, ON, Canada; Hamilton Niagara Regional Hemophilia Program, McMaster Children's Hospital, Hamilton Health Sciences, Hamilton, ON, Canada.Current treatment for severe haemophilia includes prophylactic factor replacement to prevent bleeding. Coagulation factor products have significant inter-patient variability in pharmacokinetic (PK) parameters. Optimal management requires tailoring prophylaxis to individual PK parameters. Web-based Application for the Population Pharmacokinetic Service (WAPPS) is a tool that estimates individual PK values using a population approach. Despite its growing use to help guide dosing selection, few studies have investigated its clinical impact.https://doi.org/10.17225/jhp00179haemophilia ahaemophilia bfactor viiifactor ixchildrenpharmacokinetics |
| spellingShingle | Kwan Celia Bhatt Mihir D. Strike Karen Decker Kay Matino Davide Chan Anthony K.C. Web-based Application for the Population Pharmacokinetic Service (WAPPS)'s impact on dosage selection: a single paediatric centre experience The Journal of Haemophilia Practice haemophilia a haemophilia b factor viii factor ix children pharmacokinetics |
| title | Web-based Application for the Population Pharmacokinetic Service (WAPPS)'s impact on dosage selection: a single paediatric centre experience |
| title_full | Web-based Application for the Population Pharmacokinetic Service (WAPPS)'s impact on dosage selection: a single paediatric centre experience |
| title_fullStr | Web-based Application for the Population Pharmacokinetic Service (WAPPS)'s impact on dosage selection: a single paediatric centre experience |
| title_full_unstemmed | Web-based Application for the Population Pharmacokinetic Service (WAPPS)'s impact on dosage selection: a single paediatric centre experience |
| title_short | Web-based Application for the Population Pharmacokinetic Service (WAPPS)'s impact on dosage selection: a single paediatric centre experience |
| title_sort | web based application for the population pharmacokinetic service wapps s impact on dosage selection a single paediatric centre experience |
| topic | haemophilia a haemophilia b factor viii factor ix children pharmacokinetics |
| url | https://doi.org/10.17225/jhp00179 |
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