Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep
Menbutone is a drug currently approved in several European Union (EU) countries to treat digestive disorders in different animal species. The objective of this study was to establish the pharmacokinetic parameters resulting from intravenous (IV) and intramuscular (IM) administration of this drug in...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.980818/full |
| _version_ | 1828428122616233984 |
|---|---|
| author | Raquel Diez M. Jose Diez Juan J. Garcia Jose M. Rodriguez Cristina Lopez Nelida Fernandez Matilde Sierra Ana M. Sahagun |
| author_facet | Raquel Diez M. Jose Diez Juan J. Garcia Jose M. Rodriguez Cristina Lopez Nelida Fernandez Matilde Sierra Ana M. Sahagun |
| author_sort | Raquel Diez |
| collection | DOAJ |
| description | Menbutone is a drug currently approved in several European Union (EU) countries to treat digestive disorders in different animal species. The objective of this study was to establish the pharmacokinetic parameters resulting from intravenous (IV) and intramuscular (IM) administration of this drug in sheep. Menbutone was administered to 12 animals at the dose of 10 mg/kg for both IV and IM routes. Plasma samples were collected up to 24 h (15 points, IV route; 14 points, IM route). Concentrations were determined using high-performance liquid chromatography with photodiode-array (PDA) detection, following a method validated according to the EMEA/CHMP/EWP/192217/2009 guideline. Pharmacokinetic data were analyzed by non-compartmental methods. After IV administration, a total clearance (Cl) of 63.6 ± 13.6 mL/h/kg, a volume of distribution at steady-state (Vss) of 259.6 ± 52.7 mL/kg, and an elimination half-life (t½λ) of 6.08 ± 2.48 h were calculated. After IM administration, menbutone peak plasma concentration (Cmax) was 18.8 ± 1.9 μg/mL, the time to reach Cmax (tmax) 3.75 ± 0.45 h, the mean absorption time (MAT) 3.31 ± 1.36 h, and the fraction of dose absorbed (F) 103.1 ± 23.0 %. The results obtained indicate that menbutone absorption after IM administration is quick and complete. |
| first_indexed | 2024-12-10T17:12:42Z |
| format | Article |
| id | doaj.art-96bdc20054ad44bb8641f2682374d194 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-10T17:12:42Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-96bdc20054ad44bb8641f2682374d1942022-12-22T01:40:16ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-08-01910.3389/fvets.2022.980818980818Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheepRaquel DiezM. Jose DiezJuan J. GarciaJose M. RodriguezCristina LopezNelida FernandezMatilde SierraAna M. SahagunMenbutone is a drug currently approved in several European Union (EU) countries to treat digestive disorders in different animal species. The objective of this study was to establish the pharmacokinetic parameters resulting from intravenous (IV) and intramuscular (IM) administration of this drug in sheep. Menbutone was administered to 12 animals at the dose of 10 mg/kg for both IV and IM routes. Plasma samples were collected up to 24 h (15 points, IV route; 14 points, IM route). Concentrations were determined using high-performance liquid chromatography with photodiode-array (PDA) detection, following a method validated according to the EMEA/CHMP/EWP/192217/2009 guideline. Pharmacokinetic data were analyzed by non-compartmental methods. After IV administration, a total clearance (Cl) of 63.6 ± 13.6 mL/h/kg, a volume of distribution at steady-state (Vss) of 259.6 ± 52.7 mL/kg, and an elimination half-life (t½λ) of 6.08 ± 2.48 h were calculated. After IM administration, menbutone peak plasma concentration (Cmax) was 18.8 ± 1.9 μg/mL, the time to reach Cmax (tmax) 3.75 ± 0.45 h, the mean absorption time (MAT) 3.31 ± 1.36 h, and the fraction of dose absorbed (F) 103.1 ± 23.0 %. The results obtained indicate that menbutone absorption after IM administration is quick and complete.https://www.frontiersin.org/articles/10.3389/fvets.2022.980818/fullcholereticintramuscularintravenousmenbutonepharmacokineticssheep |
| spellingShingle | Raquel Diez M. Jose Diez Juan J. Garcia Jose M. Rodriguez Cristina Lopez Nelida Fernandez Matilde Sierra Ana M. Sahagun Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep Frontiers in Veterinary Science choleretic intramuscular intravenous menbutone pharmacokinetics sheep |
| title | Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep |
| title_full | Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep |
| title_fullStr | Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep |
| title_full_unstemmed | Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep |
| title_short | Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep |
| title_sort | pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep |
| topic | choleretic intramuscular intravenous menbutone pharmacokinetics sheep |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.980818/full |
| work_keys_str_mv | AT raqueldiez pharmacokineticsofmenbutoneafterintravenousandintramuscularadministrationtosheep AT mjosediez pharmacokineticsofmenbutoneafterintravenousandintramuscularadministrationtosheep AT juanjgarcia pharmacokineticsofmenbutoneafterintravenousandintramuscularadministrationtosheep AT josemrodriguez pharmacokineticsofmenbutoneafterintravenousandintramuscularadministrationtosheep AT cristinalopez pharmacokineticsofmenbutoneafterintravenousandintramuscularadministrationtosheep AT nelidafernandez pharmacokineticsofmenbutoneafterintravenousandintramuscularadministrationtosheep AT matildesierra pharmacokineticsofmenbutoneafterintravenousandintramuscularadministrationtosheep AT anamsahagun pharmacokineticsofmenbutoneafterintravenousandintramuscularadministrationtosheep |