Breast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess: a multi-center randomized double-blind controlled trial
Abstract Although oral probiotics can improve breast microecology and alleviate the inflammatory response, there are no data regarding cases with existing abscesses. We aimed to investigate the effect of Lactobacillus fermentum CECT5716 during needle aspiration in patients with lactational breast ab...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-20756-w |
| _version_ | 1811194926153596928 |
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| author | Yi Zhang Yajun Gao Jing Qin Xiaoting Li Fei Jiang Yuanxuan Cai Hui Feng Xidong Gu Mingze Gao Lijuan Wang Yiqi Lin Yingyi Fan Bucun Xu Enli Wang Qing Shao |
| author_facet | Yi Zhang Yajun Gao Jing Qin Xiaoting Li Fei Jiang Yuanxuan Cai Hui Feng Xidong Gu Mingze Gao Lijuan Wang Yiqi Lin Yingyi Fan Bucun Xu Enli Wang Qing Shao |
| author_sort | Yi Zhang |
| collection | DOAJ |
| description | Abstract Although oral probiotics can improve breast microecology and alleviate the inflammatory response, there are no data regarding cases with existing abscesses. We aimed to investigate the effect of Lactobacillus fermentum CECT5716 during needle aspiration in patients with lactational breast abscesses. Patients (aged 20–41 years) with lactational single-cavity breast abscesses (diameter 3–6 cm) from 12 hospitals were randomly assigned to the experimental (n = 51) and control groups (n = 50). Outcome measures included the abscess cure rate on treatment day-5, delactation rate, relieving pain rate, and number of needle aspirations until day-28. The experimental group’s 5-day cure rate (43.1%) was significantly higher (p < 0.05). Breastfeeding continuation on day-5 did not differ significantly (experimental group: 88.2%, control group: 96.0%, p = 0.269). In the experimental and control groups, 19.6% and 14.0% of patients experienced moderate to severe pain on day-5, respectively, with no statistically significant differences (p = 0.451). Four patients in each group developed diarrhea, with adverse reaction rates of 7.84% and 8.0%, respectively. No adverse reactions were reported in the infants. L. fermentum can shorten the healing time in patients with lactational breast abscesses. Trial registration This study was registered in the Chinese Clinical Trial Registry ( http://www.chictr.org.cn ), registration number: ChiCTR2000032682, registration date: 6/May/ 2020; first entry date: 11/May/2020. |
| first_indexed | 2024-04-12T00:35:25Z |
| format | Article |
| id | doaj.art-96c173b1ff1b45cfa69a1a367d3a39d4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T00:35:25Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-96c173b1ff1b45cfa69a1a367d3a39d42022-12-22T03:55:11ZengNature PortfolioScientific Reports2045-23222022-10-011211810.1038/s41598-022-20756-wBreast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess: a multi-center randomized double-blind controlled trialYi Zhang0Yajun Gao1Jing Qin2Xiaoting Li3Fei Jiang4Yuanxuan Cai5Hui Feng6Xidong Gu7Mingze Gao8Lijuan Wang9Yiqi Lin10Yingyi Fan11Bucun Xu12Enli Wang13Qing Shao14Center for Prevention and Cure of Breast Diseases, Maternal and Child Health HospitalCenter for Prevention and Cure of Breast Diseases, Maternal and Child Health HospitalCenter for Prevention and Cure of Breast Diseases, Maternal and Child Health HospitalKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital and InstituteBreast Department, Obstetrics and Gynecology HospitalBreast Department, Guangzhou Women and Children’s Medical CenterBreast Department, Taiyuan Maternity and Child Health Care HospitalBreast Department, Zhejiang Provincial Hospital of Chinese MedicineBreast Department, Changde First Hospital of Traditional Chinese MedicineBreast Department, Sanya City Womenfolk and Infant Health Care HospitalBreast Department, Jilin Women and Children Health HospitalBreast Department, Beijing University of Chinese Medicine Third Affiliated HospitalBreast Department, Anyang Maternal and Child Health Care HospitalBreast Department, Shenzhen Maternity and Child Health Care HospitalBreast Department, Jiangyin People’s HospitalAbstract Although oral probiotics can improve breast microecology and alleviate the inflammatory response, there are no data regarding cases with existing abscesses. We aimed to investigate the effect of Lactobacillus fermentum CECT5716 during needle aspiration in patients with lactational breast abscesses. Patients (aged 20–41 years) with lactational single-cavity breast abscesses (diameter 3–6 cm) from 12 hospitals were randomly assigned to the experimental (n = 51) and control groups (n = 50). Outcome measures included the abscess cure rate on treatment day-5, delactation rate, relieving pain rate, and number of needle aspirations until day-28. The experimental group’s 5-day cure rate (43.1%) was significantly higher (p < 0.05). Breastfeeding continuation on day-5 did not differ significantly (experimental group: 88.2%, control group: 96.0%, p = 0.269). In the experimental and control groups, 19.6% and 14.0% of patients experienced moderate to severe pain on day-5, respectively, with no statistically significant differences (p = 0.451). Four patients in each group developed diarrhea, with adverse reaction rates of 7.84% and 8.0%, respectively. No adverse reactions were reported in the infants. L. fermentum can shorten the healing time in patients with lactational breast abscesses. Trial registration This study was registered in the Chinese Clinical Trial Registry ( http://www.chictr.org.cn ), registration number: ChiCTR2000032682, registration date: 6/May/ 2020; first entry date: 11/May/2020.https://doi.org/10.1038/s41598-022-20756-w |
| spellingShingle | Yi Zhang Yajun Gao Jing Qin Xiaoting Li Fei Jiang Yuanxuan Cai Hui Feng Xidong Gu Mingze Gao Lijuan Wang Yiqi Lin Yingyi Fan Bucun Xu Enli Wang Qing Shao Breast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess: a multi-center randomized double-blind controlled trial Scientific Reports |
| title | Breast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess: a multi-center randomized double-blind controlled trial |
| title_full | Breast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess: a multi-center randomized double-blind controlled trial |
| title_fullStr | Breast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess: a multi-center randomized double-blind controlled trial |
| title_full_unstemmed | Breast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess: a multi-center randomized double-blind controlled trial |
| title_short | Breast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess: a multi-center randomized double-blind controlled trial |
| title_sort | breast microecology improvement using probiotics following needle aspiration in patients with lactational breast abscess a multi center randomized double blind controlled trial |
| url | https://doi.org/10.1038/s41598-022-20756-w |
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