Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health
Infection with hepatitis E virus (HEV) represents the most common source of viral hepatitis globally. Although infecting over 20 million people annually in endemic regions, with major outbreaks described since the 1950s, hepatitis E remains an underestimated disease. This review gives a current view...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/10/856 |
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| author | Srinivas Reddy Pallerla Dominik Harms Reimar Johne Daniel Todt Eike Steinmann Mathias Schemmerer Jürgen J. Wenzel Jörg Hofmann James Wai Kuo Shih Heiner Wedemeyer C.-Thomas Bock Thirumalaisamy P. Velavan |
| author_facet | Srinivas Reddy Pallerla Dominik Harms Reimar Johne Daniel Todt Eike Steinmann Mathias Schemmerer Jürgen J. Wenzel Jörg Hofmann James Wai Kuo Shih Heiner Wedemeyer C.-Thomas Bock Thirumalaisamy P. Velavan |
| author_sort | Srinivas Reddy Pallerla |
| collection | DOAJ |
| description | Infection with hepatitis E virus (HEV) represents the most common source of viral hepatitis globally. Although infecting over 20 million people annually in endemic regions, with major outbreaks described since the 1950s, hepatitis E remains an underestimated disease. This review gives a current view of the global circulation and epidemiology of this emerging virus. The history of HEV, from the first reported enteric non-A non-B hepatitis outbreaks, to the discovery of the viral agent and the molecular characterization of the different human pathogenic genotypes, is discussed. Furthermore, the current state of research regarding the virology of HEV is critically assessed, and the challenges towards prevention and diagnosis, as well as clinical risks of the disease described. Together, these points aim to underline the significant impact of hepatitis E on global health and the need for further in-depth research to better understand the pathophysiology and its role in the complex disease manifestations of HEV infection. |
| first_indexed | 2024-03-10T15:27:43Z |
| format | Article |
| id | doaj.art-96c1d463838b4fd7a0553d9de1419a7d |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T15:27:43Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-96c1d463838b4fd7a0553d9de1419a7d2023-11-20T17:52:32ZengMDPI AGPathogens2076-08172020-10-0191085610.3390/pathogens9100856Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global HealthSrinivas Reddy Pallerla0Dominik Harms1Reimar Johne2Daniel Todt3Eike Steinmann4Mathias Schemmerer5Jürgen J. Wenzel6Jörg Hofmann7James Wai Kuo Shih8Heiner Wedemeyer9C.-Thomas Bock10Thirumalaisamy P. Velavan11Institute of Tropical Medicine, University of Tübingen, 72074 Tübingen, GermanyDivision of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, 13353 Berlin, GermanyUnit Viruses in Food, Department Biological Safety, German Federal Institute for Risk Assessment, 10589 Berlin, GermanyDepartment of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, GermanyDepartment of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, GermanyInstitute of Clinical Microbiology and Hygiene, National Consultant Laboratory for HAV and HEV, University Medical Center Regensburg, 93053 Regensburg, GermanyInstitute of Clinical Microbiology and Hygiene, National Consultant Laboratory for HAV and HEV, University Medical Center Regensburg, 93053 Regensburg, GermanyInstitute of Virology, Charité Universitätsmedizin Berlin, Labor Berlin-Charité-Vivantes GmbH, 13353 Berlin, GermanyXiamen Innovax Biotech Co., Ltd., Haicang, Xiamen 361022, ChinaDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30623 Hannover, GermanyInstitute of Tropical Medicine, University of Tübingen, 72074 Tübingen, GermanyInstitute of Tropical Medicine, University of Tübingen, 72074 Tübingen, GermanyInfection with hepatitis E virus (HEV) represents the most common source of viral hepatitis globally. Although infecting over 20 million people annually in endemic regions, with major outbreaks described since the 1950s, hepatitis E remains an underestimated disease. This review gives a current view of the global circulation and epidemiology of this emerging virus. The history of HEV, from the first reported enteric non-A non-B hepatitis outbreaks, to the discovery of the viral agent and the molecular characterization of the different human pathogenic genotypes, is discussed. Furthermore, the current state of research regarding the virology of HEV is critically assessed, and the challenges towards prevention and diagnosis, as well as clinical risks of the disease described. Together, these points aim to underline the significant impact of hepatitis E on global health and the need for further in-depth research to better understand the pathophysiology and its role in the complex disease manifestations of HEV infection.https://www.mdpi.com/2076-0817/9/10/856hepatitis Einfectionoutbreakepidemiologyglobal health |
| spellingShingle | Srinivas Reddy Pallerla Dominik Harms Reimar Johne Daniel Todt Eike Steinmann Mathias Schemmerer Jürgen J. Wenzel Jörg Hofmann James Wai Kuo Shih Heiner Wedemeyer C.-Thomas Bock Thirumalaisamy P. Velavan Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health Pathogens hepatitis E infection outbreak epidemiology global health |
| title | Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health |
| title_full | Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health |
| title_fullStr | Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health |
| title_full_unstemmed | Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health |
| title_short | Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health |
| title_sort | hepatitis e virus infection circulation molecular epidemiology and impact on global health |
| topic | hepatitis E infection outbreak epidemiology global health |
| url | https://www.mdpi.com/2076-0817/9/10/856 |
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