Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN

Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN

The 24‐h molecular clock is based on the stability of rhythmically expressed transcripts. The shortening of the poly(A) tail of mRNAs is often the first and rate‐limiting step that determines the lifespan of a mRNA and is catalyzed by deadenylases. Herein, we determine the catalytic site of Hesperin...

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Bibliographic Details
Main Authors: Rafailia A. A. Beta, Athanasios Kyritsis, Veroniki Douka, Eirini Papanastasi, Marianna Rizouli, Demetres D. Leonidas, Dimitrios Vlachakis, Nikolaos A. A. Balatsos
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:FEBS Open Bio
Subjects:
AtHESPERIN
circadian rhythms
deadenylation
mRNA decay
poly(A) tail
Online Access:https://doi.org/10.1002/2211-5463.13011

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