Mesenchymal stromal cell derived extracellular vesicles as a therapeutic tool: immune regulation, MSC priming, and applications to SLE
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a dysfunction of the immune system. Mesenchymal stromal cell (MSCs) derived extracellular vesicles (EVs) are nanometer-sized particles carrying a diverse range of bioactive molecules, such as proteins, miRNAs, and li...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1355845/full |
| _version_ | 1797218119298580480 |
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| author | Christophe Wong Christophe Wong Christophe Wong Ivana Stoilova Ivana Stoilova Florence Gazeau Jean-Philippe Herbeuval Jean-Philippe Herbeuval Thibaut Fourniols |
| author_facet | Christophe Wong Christophe Wong Christophe Wong Ivana Stoilova Ivana Stoilova Florence Gazeau Jean-Philippe Herbeuval Jean-Philippe Herbeuval Thibaut Fourniols |
| author_sort | Christophe Wong |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a dysfunction of the immune system. Mesenchymal stromal cell (MSCs) derived extracellular vesicles (EVs) are nanometer-sized particles carrying a diverse range of bioactive molecules, such as proteins, miRNAs, and lipids. Despite the methodological disparities, recent works on MSC-EVs have highlighted their broad immunosuppressive effect, thus driving forwards the potential of MSC-EVs in the treatment of chronic diseases. Nonetheless, their mechanism of action is still unclear, and better understanding is needed for clinical application. Therefore, we describe in this review the diverse range of bioactive molecules mediating their immunomodulatory effect, the techniques and possibilities for enhancing their immune activity, and finally the potential application to SLE. |
| first_indexed | 2024-03-08T04:51:50Z |
| format | Article |
| id | doaj.art-96c35ac2250841afb571a9000eaf9d9f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T12:12:41Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-96c35ac2250841afb571a9000eaf9d9f2024-04-08T10:22:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.13558451355845Mesenchymal stromal cell derived extracellular vesicles as a therapeutic tool: immune regulation, MSC priming, and applications to SLEChristophe Wong0Christophe Wong1Christophe Wong2Ivana Stoilova3Ivana Stoilova4Florence Gazeau5Jean-Philippe Herbeuval6Jean-Philippe Herbeuval7Thibaut Fourniols8EVerZom, Paris, FranceCentre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8601, Université Paris Cité, Paris, FranceChemistry and Biology, Modeling and Immunology for Therapy (CBMIT), Université Paris Cité, Paris, FranceCentre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8601, Université Paris Cité, Paris, FranceChemistry and Biology, Modeling and Immunology for Therapy (CBMIT), Université Paris Cité, Paris, FranceMatière et Systèmes Complexes (MSC) UMR CNRS 7057, Université Paris Cité, Paris, FranceCentre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8601, Université Paris Cité, Paris, FranceChemistry and Biology, Modeling and Immunology for Therapy (CBMIT), Université Paris Cité, Paris, FranceEVerZom, Paris, FranceSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a dysfunction of the immune system. Mesenchymal stromal cell (MSCs) derived extracellular vesicles (EVs) are nanometer-sized particles carrying a diverse range of bioactive molecules, such as proteins, miRNAs, and lipids. Despite the methodological disparities, recent works on MSC-EVs have highlighted their broad immunosuppressive effect, thus driving forwards the potential of MSC-EVs in the treatment of chronic diseases. Nonetheless, their mechanism of action is still unclear, and better understanding is needed for clinical application. Therefore, we describe in this review the diverse range of bioactive molecules mediating their immunomodulatory effect, the techniques and possibilities for enhancing their immune activity, and finally the potential application to SLE.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1355845/fullextracellular vesiclessecretomeimmune regulationmesenchymal stromal cellprimingsystemic lupus erythematosus |
| spellingShingle | Christophe Wong Christophe Wong Christophe Wong Ivana Stoilova Ivana Stoilova Florence Gazeau Jean-Philippe Herbeuval Jean-Philippe Herbeuval Thibaut Fourniols Mesenchymal stromal cell derived extracellular vesicles as a therapeutic tool: immune regulation, MSC priming, and applications to SLE Frontiers in Immunology extracellular vesicles secretome immune regulation mesenchymal stromal cell priming systemic lupus erythematosus |
| title | Mesenchymal stromal cell derived extracellular vesicles as a therapeutic tool: immune regulation, MSC priming, and applications to SLE |
| title_full | Mesenchymal stromal cell derived extracellular vesicles as a therapeutic tool: immune regulation, MSC priming, and applications to SLE |
| title_fullStr | Mesenchymal stromal cell derived extracellular vesicles as a therapeutic tool: immune regulation, MSC priming, and applications to SLE |
| title_full_unstemmed | Mesenchymal stromal cell derived extracellular vesicles as a therapeutic tool: immune regulation, MSC priming, and applications to SLE |
| title_short | Mesenchymal stromal cell derived extracellular vesicles as a therapeutic tool: immune regulation, MSC priming, and applications to SLE |
| title_sort | mesenchymal stromal cell derived extracellular vesicles as a therapeutic tool immune regulation msc priming and applications to sle |
| topic | extracellular vesicles secretome immune regulation mesenchymal stromal cell priming systemic lupus erythematosus |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1355845/full |
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