A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma

A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma

This review aims to summarize the putative role of histone deacetylases (HDACs) in rhabdomyosarcoma (RMS) and the effects of HDAC inhibitors (HDACi) on RMS by elucidating and highlighting known oncogenic pathways, mechanisms of resistance, and the synergistic potential of histone deacetylase inhibit...

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Bibliographic Details
Main Authors: Omar Selim, Clara Song, Amy Kumar, Rebecca Phelan, Arun Singh, Noah Federman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Oncology
Subjects:
rhabdomyosarcoma
histone deacetylase inhibitors
pediatric cancer
clinical trials
mutations
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1244035/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1244035/full

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