Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis

Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis

ABSTRACT Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KSα), chain length factor (KSβ), and acyl carrier protein (ACP), ar...

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Bibliographic Details
Main Authors: Kangmin Hua, Xiangyang Liu, Yuchun Zhao, Yaojie Gao, Lifeng Pan, Haoran Zhang, Zixin Deng, Ming Jiang
Format: Article
Language:English
Published: American Society for Microbiology 2020-10-01
Series:mBio
Subjects:
biosynthesis
natural product
offloading
thioesterase
type II polyketides
Online Access:https://journals.asm.org/doi/10.1128/mBio.01334-20

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