Natural Products for the Treatment of Trachoma and Chlamydia trachomatis
The neglected tropical disease (NTD) trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/20/3/4180 |
| _version_ | 1818658127935963136 |
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| author | Michael G. Potroz Nam-Joon Cho |
| author_facet | Michael G. Potroz Nam-Joon Cho |
| author_sort | Michael G. Potroz |
| collection | DOAJ |
| description | The neglected tropical disease (NTD) trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typically vary between ocular and genital infections there is a clear connection between genital C. trachomatis infections and the development of trachoma in infants, such that the solutions to these infections are closely related. It is the unique life cycle of the C. trachomatis bacteria which primarily leads to chronic infections and challenges in treatment using conventional antibiotics. This life cycle involves stages of infective elementary bodies (EBs) and reproductive reticulate bodies (RBs). Most antibiotics only target the reproductive RBs and this often leads to the need for prolonged therapy which facilitates the development of drug resistant pathogens. It is through combining several compounds to obtain multiple antimicrobial mechanisms that we are most likely to develop a reliable means to address all these issues. Traditional and ethnobotanical medicine provides valuable resources for the development of novel formulations and treatment regimes based on synergistic and multi-compound therapy. In this review we intend to summarize the existing literature on the application of natural compounds for controlling trachoma and inhibiting chlamydial bacteria and explore the potential for the development of new treatment modalities. |
| first_indexed | 2024-12-17T03:52:26Z |
| format | Article |
| id | doaj.art-96c430912bfc4e78888d94a82ba0cf78 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-17T03:52:26Z |
| publishDate | 2015-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-96c430912bfc4e78888d94a82ba0cf782022-12-21T22:04:42ZengMDPI AGMolecules1420-30492015-03-012034180420310.3390/molecules20034180molecules20034180Natural Products for the Treatment of Trachoma and Chlamydia trachomatisMichael G. Potroz0Nam-Joon Cho1School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, SingaporeSchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, SingaporeThe neglected tropical disease (NTD) trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typically vary between ocular and genital infections there is a clear connection between genital C. trachomatis infections and the development of trachoma in infants, such that the solutions to these infections are closely related. It is the unique life cycle of the C. trachomatis bacteria which primarily leads to chronic infections and challenges in treatment using conventional antibiotics. This life cycle involves stages of infective elementary bodies (EBs) and reproductive reticulate bodies (RBs). Most antibiotics only target the reproductive RBs and this often leads to the need for prolonged therapy which facilitates the development of drug resistant pathogens. It is through combining several compounds to obtain multiple antimicrobial mechanisms that we are most likely to develop a reliable means to address all these issues. Traditional and ethnobotanical medicine provides valuable resources for the development of novel formulations and treatment regimes based on synergistic and multi-compound therapy. In this review we intend to summarize the existing literature on the application of natural compounds for controlling trachoma and inhibiting chlamydial bacteria and explore the potential for the development of new treatment modalities.http://www.mdpi.com/1420-3049/20/3/4180trachomaChlamydia trachomatisnatural productsantibacterial |
| spellingShingle | Michael G. Potroz Nam-Joon Cho Natural Products for the Treatment of Trachoma and Chlamydia trachomatis Molecules trachoma Chlamydia trachomatis natural products antibacterial |
| title | Natural Products for the Treatment of Trachoma and Chlamydia trachomatis |
| title_full | Natural Products for the Treatment of Trachoma and Chlamydia trachomatis |
| title_fullStr | Natural Products for the Treatment of Trachoma and Chlamydia trachomatis |
| title_full_unstemmed | Natural Products for the Treatment of Trachoma and Chlamydia trachomatis |
| title_short | Natural Products for the Treatment of Trachoma and Chlamydia trachomatis |
| title_sort | natural products for the treatment of trachoma and chlamydia trachomatis |
| topic | trachoma Chlamydia trachomatis natural products antibacterial |
| url | http://www.mdpi.com/1420-3049/20/3/4180 |
| work_keys_str_mv | AT michaelgpotroz naturalproductsforthetreatmentoftrachomaandchlamydiatrachomatis AT namjooncho naturalproductsforthetreatmentoftrachomaandchlamydiatrachomatis |