Virtual Reality as Tool for Bioprinting Quality Inspection: A Proof of Principle
As virtual reality (VR) has drastically evolved over the past few years, the field of applications of VR flourished way beyond the gaming industry. While commercial VR solutions might be available, there is a need to develop a workflow for specific applications. Bioprinting represents such an exampl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.895842/full |
| _version_ | 1817968448320307200 |
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| author | Sarah Gretzinger Sarah Gretzinger Barbara Schmieg Barbara Schmieg Gisela Guthausen Gisela Guthausen Jürgen Hubbuch Jürgen Hubbuch |
| author_facet | Sarah Gretzinger Sarah Gretzinger Barbara Schmieg Barbara Schmieg Gisela Guthausen Gisela Guthausen Jürgen Hubbuch Jürgen Hubbuch |
| author_sort | Sarah Gretzinger |
| collection | DOAJ |
| description | As virtual reality (VR) has drastically evolved over the past few years, the field of applications of VR flourished way beyond the gaming industry. While commercial VR solutions might be available, there is a need to develop a workflow for specific applications. Bioprinting represents such an example. Here, complex 3D data is generated and needs to be visualized in the context of quality control. We demonstrate that the transfer to a commercially available VR software is possible by introducing an optimized workflow. In the present work, we developed a workflow for the visualization of the critical quality attribute (cQA) cell distribution in bioprinted (extrusion-based) samples in VR. The cQA cell distribution is directly influenced by the pre-processing step mixing of cell material in the bioink. Magnetic Resonance Imaging (MRI) was used as an analytical tool to generate spatially resolved 2.5 and 3D data of the bioprinted objects. A sample with poor quality in respect of the cQA cell distribution was identified as its inhomogeneous cell distribution could be displayed spatially resolved in VR. The described workflow facilitates the usage of VR as a tool for quality inspection in the field of bioprinting and represents a powerful tool for visualization of complex 3D MRI data. |
| first_indexed | 2024-04-13T20:09:10Z |
| format | Article |
| id | doaj.art-96c483e480474b278bed120c8ab5ac9e |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-13T20:09:10Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-96c483e480474b278bed120c8ab5ac9e2022-12-22T02:31:55ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-06-011010.3389/fbioe.2022.895842895842Virtual Reality as Tool for Bioprinting Quality Inspection: A Proof of PrincipleSarah Gretzinger0Sarah Gretzinger1Barbara Schmieg2Barbara Schmieg3Gisela Guthausen4Gisela Guthausen5Jürgen Hubbuch6Jürgen Hubbuch7Institute of Functional Interfaces, Karlsruhe Institute of Technology (KIT), Karlsruhe, GermanyInstitute of Engineering in Life Sciences, Section IV: Molecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, GermanyInstitute of Functional Interfaces, Karlsruhe Institute of Technology (KIT), Karlsruhe, GermanyInstitute of Engineering in Life Sciences, Section IV: Molecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, GermanyInstitute of Mechanical Process Engineering and Mechanics, Karlsruhe Institute of Technology (KIT), Karlsruhe, GermanyEngler Bunte Institute Water Chemistry and Technology, Karlsruhe Institute of Technology (KIT), Karlsruhe, GermanyInstitute of Functional Interfaces, Karlsruhe Institute of Technology (KIT), Karlsruhe, GermanyInstitute of Engineering in Life Sciences, Section IV: Molecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, GermanyAs virtual reality (VR) has drastically evolved over the past few years, the field of applications of VR flourished way beyond the gaming industry. While commercial VR solutions might be available, there is a need to develop a workflow for specific applications. Bioprinting represents such an example. Here, complex 3D data is generated and needs to be visualized in the context of quality control. We demonstrate that the transfer to a commercially available VR software is possible by introducing an optimized workflow. In the present work, we developed a workflow for the visualization of the critical quality attribute (cQA) cell distribution in bioprinted (extrusion-based) samples in VR. The cQA cell distribution is directly influenced by the pre-processing step mixing of cell material in the bioink. Magnetic Resonance Imaging (MRI) was used as an analytical tool to generate spatially resolved 2.5 and 3D data of the bioprinted objects. A sample with poor quality in respect of the cQA cell distribution was identified as its inhomogeneous cell distribution could be displayed spatially resolved in VR. The described workflow facilitates the usage of VR as a tool for quality inspection in the field of bioprinting and represents a powerful tool for visualization of complex 3D MRI data.https://www.frontiersin.org/articles/10.3389/fbioe.2022.895842/fullvirtual reality (VR)bioprintingquality inspectionmagnetic resonance imaging (MRI)cell distribution |
| spellingShingle | Sarah Gretzinger Sarah Gretzinger Barbara Schmieg Barbara Schmieg Gisela Guthausen Gisela Guthausen Jürgen Hubbuch Jürgen Hubbuch Virtual Reality as Tool for Bioprinting Quality Inspection: A Proof of Principle Frontiers in Bioengineering and Biotechnology virtual reality (VR) bioprinting quality inspection magnetic resonance imaging (MRI) cell distribution |
| title | Virtual Reality as Tool for Bioprinting Quality Inspection: A Proof of Principle |
| title_full | Virtual Reality as Tool for Bioprinting Quality Inspection: A Proof of Principle |
| title_fullStr | Virtual Reality as Tool for Bioprinting Quality Inspection: A Proof of Principle |
| title_full_unstemmed | Virtual Reality as Tool for Bioprinting Quality Inspection: A Proof of Principle |
| title_short | Virtual Reality as Tool for Bioprinting Quality Inspection: A Proof of Principle |
| title_sort | virtual reality as tool for bioprinting quality inspection a proof of principle |
| topic | virtual reality (VR) bioprinting quality inspection magnetic resonance imaging (MRI) cell distribution |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.895842/full |
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