Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change
Abstract Reconsolidation turns memories into a responsive state that allows their modulation until they stabilize again. This phenomenon attracted remarkable attention due to its potential impact on therapeutics and education. Recent evidence revealed that different memories undergo reconsolidation...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05666-5 |
| _version_ | 1797376854128066560 |
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| author | Matías Nicolás Schroeder Camila L. Fullio Fabricio Ballarini Diego Moncada |
| author_facet | Matías Nicolás Schroeder Camila L. Fullio Fabricio Ballarini Diego Moncada |
| author_sort | Matías Nicolás Schroeder |
| collection | DOAJ |
| description | Abstract Reconsolidation turns memories into a responsive state that allows their modulation until they stabilize again. This phenomenon attracted remarkable attention due to its potential impact on therapeutics and education. Recent evidence revealed that different memories undergo reconsolidation via a behavioral tagging process. Thus, their re-stabilization involves setting “reconsolidation-tags” and synthesizing plasticity-related proteins for their capture at the tagged sites. Here, we studied the possibility of affecting these fundamental mechanisms to modulate reconsolidation. Our findings, in laboratory rats, indicate that exploring a novel environment 60 min before or after memory reactivation improves spatial object recognition memory by promoting protein synthesis. Conversely, experiencing novelty immediately after reactivation impairs the reconsolidation by affecting the tags. Similar effects, but with a different optimal time window for improvement, occur in inhibitory avoidance memory. These results highlight the possibility of modulating existing memories using non-invasive interventions that selectively affect the fundamental mechanisms of behavioral tagging during their reconsolidation. |
| first_indexed | 2024-03-08T19:44:35Z |
| format | Article |
| id | doaj.art-96c5fd68696d4cad82a87792362c4e0f |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-08T19:44:35Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-96c5fd68696d4cad82a87792362c4e0f2023-12-24T12:26:38ZengNature PortfolioCommunications Biology2399-36422023-12-01611910.1038/s42003-023-05666-5Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of changeMatías Nicolás Schroeder0Camila L. Fullio1Fabricio Ballarini2Diego Moncada3Laboratorio de Neurofisiología de la Memoria, Instituto de Biología Celular y Neurociencia, Facultad de Medicina (UBA/CONICET) - Instituto Tecnológico de Buenos Aires (ITBA)Laboratorio de Neurofisiología de la Memoria, Instituto de Biología Celular y Neurociencia “Prof. E. De Robertis” (IBCN), Facultad de Medicina, UBA-CONICETLaboratorio de neurociencia translacional, Instituto de Biología Celular y Neurociencia “Prof. E. De Robertis” (IBCN), Facultad de Medicina, UBA-CONICETLaboratorio de Neurofisiología de la Memoria, Instituto de Biología Celular y Neurociencia, Facultad de Medicina (UBA/CONICET) - Instituto Tecnológico de Buenos Aires (ITBA)Abstract Reconsolidation turns memories into a responsive state that allows their modulation until they stabilize again. This phenomenon attracted remarkable attention due to its potential impact on therapeutics and education. Recent evidence revealed that different memories undergo reconsolidation via a behavioral tagging process. Thus, their re-stabilization involves setting “reconsolidation-tags” and synthesizing plasticity-related proteins for their capture at the tagged sites. Here, we studied the possibility of affecting these fundamental mechanisms to modulate reconsolidation. Our findings, in laboratory rats, indicate that exploring a novel environment 60 min before or after memory reactivation improves spatial object recognition memory by promoting protein synthesis. Conversely, experiencing novelty immediately after reactivation impairs the reconsolidation by affecting the tags. Similar effects, but with a different optimal time window for improvement, occur in inhibitory avoidance memory. These results highlight the possibility of modulating existing memories using non-invasive interventions that selectively affect the fundamental mechanisms of behavioral tagging during their reconsolidation.https://doi.org/10.1038/s42003-023-05666-5 |
| spellingShingle | Matías Nicolás Schroeder Camila L. Fullio Fabricio Ballarini Diego Moncada Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change Communications Biology |
| title | Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change |
| title_full | Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change |
| title_fullStr | Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change |
| title_full_unstemmed | Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change |
| title_short | Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change |
| title_sort | modulation of memory reconsolidation by adjacent novel tasks timing defines the nature of change |
| url | https://doi.org/10.1038/s42003-023-05666-5 |
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