Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia

Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia

The NOD-like receptor pyrin domain 3 (NLRP3) inflammasome is activated during atherogenesis, but how this occurs is unclear. Here, we explored the mechanisms activating and regulating NLRP3 inflammasomes via the acid sphingomyelinase (ASM)-ceramide signaling pathway. As a neointima formation model,...

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Bibliographic Details
Main Authors: Xinxu Yuan, Owais M. Bhat, Yao Zou, Xiang Li, Yang Zhang, Pin-Lan Li
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Lipid Research
Subjects:
carotid artery
endothelial cells
lysosomal ceramide
redox signaling
amitriptyline
NADPH
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522001316

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