Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver.

<h4>Background</h4>Little is known about the muscle condition in children with obesity.<h4>Objectives</h4>To investigate the effect of obesity and fatty liver on muscle area and muscle fat in children and young adults.<h4>Materials and methods</h4>We evaluated con...

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Main Authors: Salman S Albakheet, Mi-Jung Lee, Haesung Yoon, Hyun Joo Shin, Hong Koh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0259948
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author Salman S Albakheet
Mi-Jung Lee
Haesung Yoon
Hyun Joo Shin
Hong Koh
author_facet Salman S Albakheet
Mi-Jung Lee
Haesung Yoon
Hyun Joo Shin
Hong Koh
author_sort Salman S Albakheet
collection DOAJ
description <h4>Background</h4>Little is known about the muscle condition in children with obesity.<h4>Objectives</h4>To investigate the effect of obesity and fatty liver on muscle area and muscle fat in children and young adults.<h4>Materials and methods</h4>We evaluated consecutive liver fat quantification MRIs in children and young adults between June 2015 and April 2019. We obtained hepatic fat and paraspinal muscle fat at mid L2 from the fat map, psoas muscle area (PMA) at mid L3, and z-score of PMA. The patient's age, height and weight at the time of the MRI were recorded. Body mass index (BMI) z-score was also calculated. Spearman correlation and partial correlation analyses were performed. Univariate and multivariate regression analyses were also performed using significant variables.<h4>Results</h4>A total of 132 patients (97 male) were included with a median age of 13.0 years (interquartile range 11-16 years). The median BMI was 23.7 kg/m2 (interquartile range 21.2-27.7 kg/m2). The weight, BMI, liver fat, and z-score of PMA were all higher in male patients than they were in female patients. The amount of liver fat had no correlation with muscle fat or PMA z-score after adjusting BMI. However, the BMI z-score was positively correlated with the PMA z-score (ρ = 0.432, p<0.001) even after adjusting for liver fat. On regression analyses, the BMI z-score had linear positive relationship with PMA z-score (β = 0.289, p<0.001) and muscle fat (β = 0.218, p = 0.016).<h4>Conclusions</h4>Male children and young adults have greater PMA than do female children and young adults. Obesity is associated with higher PMA and paraspinal muscle fat. However, liver fat is not related with the muscle condition in children and young adults.
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spelling doaj.art-96cbc2ba74f64c0397ab99eb7a4578082022-12-21T18:44:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011611e025994810.1371/journal.pone.0259948Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver.Salman S AlbakheetMi-Jung LeeHaesung YoonHyun Joo ShinHong Koh<h4>Background</h4>Little is known about the muscle condition in children with obesity.<h4>Objectives</h4>To investigate the effect of obesity and fatty liver on muscle area and muscle fat in children and young adults.<h4>Materials and methods</h4>We evaluated consecutive liver fat quantification MRIs in children and young adults between June 2015 and April 2019. We obtained hepatic fat and paraspinal muscle fat at mid L2 from the fat map, psoas muscle area (PMA) at mid L3, and z-score of PMA. The patient's age, height and weight at the time of the MRI were recorded. Body mass index (BMI) z-score was also calculated. Spearman correlation and partial correlation analyses were performed. Univariate and multivariate regression analyses were also performed using significant variables.<h4>Results</h4>A total of 132 patients (97 male) were included with a median age of 13.0 years (interquartile range 11-16 years). The median BMI was 23.7 kg/m2 (interquartile range 21.2-27.7 kg/m2). The weight, BMI, liver fat, and z-score of PMA were all higher in male patients than they were in female patients. The amount of liver fat had no correlation with muscle fat or PMA z-score after adjusting BMI. However, the BMI z-score was positively correlated with the PMA z-score (ρ = 0.432, p<0.001) even after adjusting for liver fat. On regression analyses, the BMI z-score had linear positive relationship with PMA z-score (β = 0.289, p<0.001) and muscle fat (β = 0.218, p = 0.016).<h4>Conclusions</h4>Male children and young adults have greater PMA than do female children and young adults. Obesity is associated with higher PMA and paraspinal muscle fat. However, liver fat is not related with the muscle condition in children and young adults.https://doi.org/10.1371/journal.pone.0259948
spellingShingle Salman S Albakheet
Mi-Jung Lee
Haesung Yoon
Hyun Joo Shin
Hong Koh
Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver.
PLoS ONE
title Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver.
title_full Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver.
title_fullStr Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver.
title_full_unstemmed Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver.
title_short Psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver.
title_sort psoas muscle area and paraspinal muscle fat in children and young adults with or without obesity and fatty liver
url https://doi.org/10.1371/journal.pone.0259948
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