Neoadjuvant chemotherapy in the setting of locally advanced olfactory neuroblastoma with intracranial extension
Olfactory neuroblastoma (esthesioneuroblastoma) is a rare malignant tumor of neuroectodermal origin. With only about 1,000 cases reported, there are no clear guidelines regarding management of this disease. Intracranial extension and orbital involvement have been shown to be independent risk factor...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2011-01-01
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| Series: | Rare Tumors |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/rt/article/view/2180 |
| _version_ | 1818513775278424064 |
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| author | Raid Aljumaily John S. Nystrom Richard O. Wein |
| author_facet | Raid Aljumaily John S. Nystrom Richard O. Wein |
| author_sort | Raid Aljumaily |
| collection | DOAJ |
| description | Olfactory neuroblastoma (esthesioneuroblastoma) is a rare malignant tumor of neuroectodermal origin. With only about 1,000 cases reported, there are no clear guidelines regarding management of this disease. Intracranial extension and orbital involvement have been shown to be independent risk factors associated with poorer outcomes. We hereby report a case of a 46-year old male presented with an 8-month history of progressive nasal obstruction and intermittent right-sided epistaxis associated with anosmia and increased pressure sensation in and around the right eye. Further evaluation revealed a large enhancing heterogeneous cystic and solid mass in the right nasal cavity measuring 5.0¥5.3¥4.6 cm with extension superiorly into the anterior cranial fossa and frontal lobes, ethmoid and sphenoid sinuses. A biopsy of this mass confirmed high grade olfactory neuroblastoma. Because of the intra-cranial extension, a decision was made to start neoadjuvant chemotherapy with cisplatin and etoposide. The patient had very good response to this treatment on a repeat imaging study and went on to have resection of this mass. Post-operatively, he received radiation therapy to the tumor bed and 2 more cycles of chemotherapy. He has been followed now for more than 8 months with no evidence of disease recurrence. |
| first_indexed | 2024-12-11T00:06:13Z |
| format | Article |
| id | doaj.art-96cc97bd7b9a44668490cbaabb7fcf14 |
| institution | Directory Open Access Journal |
| issn | 2036-3605 2036-3613 |
| language | English |
| last_indexed | 2024-12-11T00:06:13Z |
| publishDate | 2011-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-96cc97bd7b9a44668490cbaabb7fcf142022-12-22T01:28:19ZengSAGE PublishingRare Tumors2036-36052036-36132011-01-0131e1e110.4081/rt.2011.e11352Neoadjuvant chemotherapy in the setting of locally advanced olfactory neuroblastoma with intracranial extensionRaid Aljumaily0John S. NystromRichard O. WeinTufts Medical CenterOlfactory neuroblastoma (esthesioneuroblastoma) is a rare malignant tumor of neuroectodermal origin. With only about 1,000 cases reported, there are no clear guidelines regarding management of this disease. Intracranial extension and orbital involvement have been shown to be independent risk factors associated with poorer outcomes. We hereby report a case of a 46-year old male presented with an 8-month history of progressive nasal obstruction and intermittent right-sided epistaxis associated with anosmia and increased pressure sensation in and around the right eye. Further evaluation revealed a large enhancing heterogeneous cystic and solid mass in the right nasal cavity measuring 5.0¥5.3¥4.6 cm with extension superiorly into the anterior cranial fossa and frontal lobes, ethmoid and sphenoid sinuses. A biopsy of this mass confirmed high grade olfactory neuroblastoma. Because of the intra-cranial extension, a decision was made to start neoadjuvant chemotherapy with cisplatin and etoposide. The patient had very good response to this treatment on a repeat imaging study and went on to have resection of this mass. Post-operatively, he received radiation therapy to the tumor bed and 2 more cycles of chemotherapy. He has been followed now for more than 8 months with no evidence of disease recurrence.http://www.pagepress.org/journals/index.php/rt/article/view/2180Olfactory Neuroblastomacisplatinetoposideneoadjuvant chemotherapy |
| spellingShingle | Raid Aljumaily John S. Nystrom Richard O. Wein Neoadjuvant chemotherapy in the setting of locally advanced olfactory neuroblastoma with intracranial extension Rare Tumors Olfactory Neuroblastoma cisplatin etoposide neoadjuvant chemotherapy |
| title | Neoadjuvant chemotherapy in the setting of locally advanced olfactory neuroblastoma with intracranial extension |
| title_full | Neoadjuvant chemotherapy in the setting of locally advanced olfactory neuroblastoma with intracranial extension |
| title_fullStr | Neoadjuvant chemotherapy in the setting of locally advanced olfactory neuroblastoma with intracranial extension |
| title_full_unstemmed | Neoadjuvant chemotherapy in the setting of locally advanced olfactory neuroblastoma with intracranial extension |
| title_short | Neoadjuvant chemotherapy in the setting of locally advanced olfactory neuroblastoma with intracranial extension |
| title_sort | neoadjuvant chemotherapy in the setting of locally advanced olfactory neuroblastoma with intracranial extension |
| topic | Olfactory Neuroblastoma cisplatin etoposide neoadjuvant chemotherapy |
| url | http://www.pagepress.org/journals/index.php/rt/article/view/2180 |
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