The Role of BCL-2 and PD-1/PD-L1 Pathway in Pathogenesis of Myelodysplastic Syndromes
Myelodysplastic syndromes (MDSs) belong to a group of clonal bone marrow malignancies. In light of the emergence of new molecules, a significant contribution to the understanding of the pathogenesis of the disease is the study of the B-cell CLL/lymphoma 2 (BCL-2) and the programmed cell death recept...
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| author | Bartłomiej Kuszczak Tomasz Wróbel Katarzyna Wicherska-Pawłowska Justyna Rybka |
| author_facet | Bartłomiej Kuszczak Tomasz Wróbel Katarzyna Wicherska-Pawłowska Justyna Rybka |
| author_sort | Bartłomiej Kuszczak |
| collection | DOAJ |
| description | Myelodysplastic syndromes (MDSs) belong to a group of clonal bone marrow malignancies. In light of the emergence of new molecules, a significant contribution to the understanding of the pathogenesis of the disease is the study of the B-cell CLL/lymphoma 2 (BCL-2) and the programmed cell death receptor 1 (PD-1) protein and its ligands. BCL-2-family proteins are involved in the regulation of the intrinsic apoptosis pathway. Disruptions in their interactions promote the progression and resistance of MDSs. They have become an important target for specific drugs. Bone marrow cytoarchitecture may prove to be a predictor of response to its use. The challenge is the observed resistance to venetoclax, for which the MCL-1 protein may be largely responsible. Molecules with the potential to break the associated resistance include S63845, S64315, chidamide and arsenic trioxide (ATO). Despite promising in vitro studies, the role of PD-1/PD-L1 pathway inhibitors has not yet been established. Knockdown of the PD-L1 gene in preclinical studies was associated with increased levels of BCL-2 and MCL-1 in lymphocytes T, which could increase their survival and promote tumor apoptosis. A trial (NCT03969446) is currently underway to combine inhibitors from both groups. |
| first_indexed | 2024-03-11T07:22:47Z |
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| id | doaj.art-96cca9f2ebe04c408b4fddeb3f332543 |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:22:47Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-96cca9f2ebe04c408b4fddeb3f3325432023-11-17T07:52:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01245470810.3390/ijms24054708The Role of BCL-2 and PD-1/PD-L1 Pathway in Pathogenesis of Myelodysplastic SyndromesBartłomiej Kuszczak0Tomasz Wróbel1Katarzyna Wicherska-Pawłowska2Justyna Rybka3Department and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Ludwika Pasteura 4 Street, 50-367 Wroclaw, PolandDepartment and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Ludwika Pasteura 4 Street, 50-367 Wroclaw, PolandDepartment and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Ludwika Pasteura 4 Street, 50-367 Wroclaw, PolandDepartment and Clinic of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Ludwika Pasteura 4 Street, 50-367 Wroclaw, PolandMyelodysplastic syndromes (MDSs) belong to a group of clonal bone marrow malignancies. In light of the emergence of new molecules, a significant contribution to the understanding of the pathogenesis of the disease is the study of the B-cell CLL/lymphoma 2 (BCL-2) and the programmed cell death receptor 1 (PD-1) protein and its ligands. BCL-2-family proteins are involved in the regulation of the intrinsic apoptosis pathway. Disruptions in their interactions promote the progression and resistance of MDSs. They have become an important target for specific drugs. Bone marrow cytoarchitecture may prove to be a predictor of response to its use. The challenge is the observed resistance to venetoclax, for which the MCL-1 protein may be largely responsible. Molecules with the potential to break the associated resistance include S63845, S64315, chidamide and arsenic trioxide (ATO). Despite promising in vitro studies, the role of PD-1/PD-L1 pathway inhibitors has not yet been established. Knockdown of the PD-L1 gene in preclinical studies was associated with increased levels of BCL-2 and MCL-1 in lymphocytes T, which could increase their survival and promote tumor apoptosis. A trial (NCT03969446) is currently underway to combine inhibitors from both groups.https://www.mdpi.com/1422-0067/24/5/4708myelodysplastic syndromesBCL-2MCL-1PD-1PD-L1BH3-mimetics |
| spellingShingle | Bartłomiej Kuszczak Tomasz Wróbel Katarzyna Wicherska-Pawłowska Justyna Rybka The Role of BCL-2 and PD-1/PD-L1 Pathway in Pathogenesis of Myelodysplastic Syndromes International Journal of Molecular Sciences myelodysplastic syndromes BCL-2 MCL-1 PD-1 PD-L1 BH3-mimetics |
| title | The Role of BCL-2 and PD-1/PD-L1 Pathway in Pathogenesis of Myelodysplastic Syndromes |
| title_full | The Role of BCL-2 and PD-1/PD-L1 Pathway in Pathogenesis of Myelodysplastic Syndromes |
| title_fullStr | The Role of BCL-2 and PD-1/PD-L1 Pathway in Pathogenesis of Myelodysplastic Syndromes |
| title_full_unstemmed | The Role of BCL-2 and PD-1/PD-L1 Pathway in Pathogenesis of Myelodysplastic Syndromes |
| title_short | The Role of BCL-2 and PD-1/PD-L1 Pathway in Pathogenesis of Myelodysplastic Syndromes |
| title_sort | role of bcl 2 and pd 1 pd l1 pathway in pathogenesis of myelodysplastic syndromes |
| topic | myelodysplastic syndromes BCL-2 MCL-1 PD-1 PD-L1 BH3-mimetics |
| url | https://www.mdpi.com/1422-0067/24/5/4708 |
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