The biased apelin receptor agonist, MM07, reverses Sugen/hypoxia-induced pulmonary arterial hypertension as effectively as the endothelin antagonist macitentan

The biased apelin receptor agonist, MM07, reverses Sugen/hypoxia-induced pulmonary arterial hypertension as effectively as the endothelin antagonist macitentan

Introduction: Pulmonary arterial hypertension (PAH) is characterised by endothelial dysfunction and pathological vascular remodelling, resulting in the occlusion of pulmonary arteries and arterioles, right ventricular hypertrophy, and eventually fatal heart failure. Targeting the apelin receptor wit...

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Bibliographic Details
Main Authors: Thomas L. Williams, Duuamene Nyimanu, Rhoda E. Kuc, Richard Foster, Robert C. Glen, Janet J. Maguire, Anthony P. Davenport
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Pharmacology
Subjects:
GPCR
apelin receptor
apelin
MM07
biased signalling
pulmonary hypertension
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1369489/full

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