Lacticaseibacillus casei T1 attenuates Helicobacter pylori-induced inflammation and gut microbiota disorders in mice
Abstract Probiotics are defined as live microbial food elements that are beneficial to human health. Lacticaseibacillus casei T1 was considered to have potential as a bioactive ingredient in functional foods, which was isolated from kurut. Previous research by our group proved that L. casei T1 could...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Microbiology |
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| Online Access: | https://doi.org/10.1186/s12866-023-02782-4 |
| _version_ | 1811166072444813312 |
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| author | Zhihao Yu Mei Cao Jingshan Peng Daoyan Wu Shu Li Chengmeng Wu Liting Qing Andong Zhang Wenjie Wang Min Huang Jian Zhao |
| author_facet | Zhihao Yu Mei Cao Jingshan Peng Daoyan Wu Shu Li Chengmeng Wu Liting Qing Andong Zhang Wenjie Wang Min Huang Jian Zhao |
| author_sort | Zhihao Yu |
| collection | DOAJ |
| description | Abstract Probiotics are defined as live microbial food elements that are beneficial to human health. Lacticaseibacillus casei T1 was considered to have potential as a bioactive ingredient in functional foods, which was isolated from kurut. Previous research by our group proved that L. casei T1 could prevent inflammatory responses caused by Helicobacter pylori. This study aimed to investigate whether treatment with L. casei T1 resulted in a suppressive effect on H. pylori-induced oxidative stress and inflammatory responses. The results showed that treatment with L. casei T1 could relieve H. pylori-induced overexpression of inflammatory cytokines in GES-1 cells. Experiments in animals suggested that taking long-term L. casei T1 could reduce oxidative stress and inflammatory cytokines and improve H. pylori-induced gastric mucosal damage. Furthermore, taking L. casei T1 could increase the relative abundance of beneficial intestinal bacterium (Lachnospiraceae and Odoribacter) of H. pylori-infected mice and help in maintaining the balance of intestinal microflora. Collectively, L. casei T1 had certain degrees of therapeutic effect against H. pylori. In the future, it combined with antibiotics for H. pylori eradication deserves further study. |
| first_indexed | 2024-04-10T15:46:34Z |
| format | Article |
| id | doaj.art-96d221326dc4427389a59e1dab975eef |
| institution | Directory Open Access Journal |
| issn | 1471-2180 |
| language | English |
| last_indexed | 2024-04-10T15:46:34Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj.art-96d221326dc4427389a59e1dab975eef2023-02-12T12:05:55ZengBMCBMC Microbiology1471-21802023-02-0123111310.1186/s12866-023-02782-4Lacticaseibacillus casei T1 attenuates Helicobacter pylori-induced inflammation and gut microbiota disorders in miceZhihao Yu0Mei Cao1Jingshan Peng2Daoyan Wu3Shu Li4Chengmeng Wu5Liting Qing6Andong Zhang7Wenjie Wang8Min Huang9Jian Zhao10Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan UniversityCore Laboratory, School of Medicine, Sichuan Provincial People’s Hospital Affiliated to University of Electronic Science and Technology of ChinaKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan UniversityDepartment of Microbiology, School of Basic Medical Sciences, Guizhou Medical UniversityKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan UniversityKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan UniversityKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan UniversityKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan UniversityKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan UniversityIrradiation Preservation Technology Key Laboratory of Sichuan Province, Sichuan Institute of Atomic EnergyKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan UniversityAbstract Probiotics are defined as live microbial food elements that are beneficial to human health. Lacticaseibacillus casei T1 was considered to have potential as a bioactive ingredient in functional foods, which was isolated from kurut. Previous research by our group proved that L. casei T1 could prevent inflammatory responses caused by Helicobacter pylori. This study aimed to investigate whether treatment with L. casei T1 resulted in a suppressive effect on H. pylori-induced oxidative stress and inflammatory responses. The results showed that treatment with L. casei T1 could relieve H. pylori-induced overexpression of inflammatory cytokines in GES-1 cells. Experiments in animals suggested that taking long-term L. casei T1 could reduce oxidative stress and inflammatory cytokines and improve H. pylori-induced gastric mucosal damage. Furthermore, taking L. casei T1 could increase the relative abundance of beneficial intestinal bacterium (Lachnospiraceae and Odoribacter) of H. pylori-infected mice and help in maintaining the balance of intestinal microflora. Collectively, L. casei T1 had certain degrees of therapeutic effect against H. pylori. In the future, it combined with antibiotics for H. pylori eradication deserves further study.https://doi.org/10.1186/s12866-023-02782-4H. pyloriLacticaseibacillus caseiProbioticsInflammationOxidative stress |
| spellingShingle | Zhihao Yu Mei Cao Jingshan Peng Daoyan Wu Shu Li Chengmeng Wu Liting Qing Andong Zhang Wenjie Wang Min Huang Jian Zhao Lacticaseibacillus casei T1 attenuates Helicobacter pylori-induced inflammation and gut microbiota disorders in mice BMC Microbiology H. pylori Lacticaseibacillus casei Probiotics Inflammation Oxidative stress |
| title | Lacticaseibacillus casei T1 attenuates Helicobacter pylori-induced inflammation and gut microbiota disorders in mice |
| title_full | Lacticaseibacillus casei T1 attenuates Helicobacter pylori-induced inflammation and gut microbiota disorders in mice |
| title_fullStr | Lacticaseibacillus casei T1 attenuates Helicobacter pylori-induced inflammation and gut microbiota disorders in mice |
| title_full_unstemmed | Lacticaseibacillus casei T1 attenuates Helicobacter pylori-induced inflammation and gut microbiota disorders in mice |
| title_short | Lacticaseibacillus casei T1 attenuates Helicobacter pylori-induced inflammation and gut microbiota disorders in mice |
| title_sort | lacticaseibacillus casei t1 attenuates helicobacter pylori induced inflammation and gut microbiota disorders in mice |
| topic | H. pylori Lacticaseibacillus casei Probiotics Inflammation Oxidative stress |
| url | https://doi.org/10.1186/s12866-023-02782-4 |
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