Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
Here Kumar et al. show that increased intestinal permeability reduces hepatic de novo lipogenesis, affecting plasma membrane fluidity and lifespan of RBCs, and the resulting increase in iron levels promotes bacterial growth. This mechanism may explain the increased risk of sepsis associated with inf...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-14182-2 |
| _version_ | 1819129794624749568 |
|---|---|
| author | Manish Kumar Aralia Leon Coria Steve Cornick Björn Petri Shyamchand Mayengbam Humberto B. Jijon France Moreau Jane Shearer Kris Chadee |
| author_facet | Manish Kumar Aralia Leon Coria Steve Cornick Björn Petri Shyamchand Mayengbam Humberto B. Jijon France Moreau Jane Shearer Kris Chadee |
| author_sort | Manish Kumar |
| collection | DOAJ |
| description | Here Kumar et al. show that increased intestinal permeability reduces hepatic de novo lipogenesis, affecting plasma membrane fluidity and lifespan of RBCs, and the resulting increase in iron levels promotes bacterial growth. This mechanism may explain the increased risk of sepsis associated with inflammatory bowel disease. |
| first_indexed | 2024-12-22T08:49:23Z |
| format | Article |
| id | doaj.art-96d4615ce4ea4d449b6fdbc7f7f39a95 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:49:23Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-96d4615ce4ea4d449b6fdbc7f7f39a952022-12-21T18:32:01ZengNature PortfolioNature Communications2041-17232020-01-0111111510.1038/s41467-019-14182-2Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recyclingManish Kumar0Aralia Leon Coria1Steve Cornick2Björn Petri3Shyamchand Mayengbam4Humberto B. Jijon5France Moreau6Jane Shearer7Kris Chadee8Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Health Sciences CentreDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Health Sciences CentreDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Health Sciences CentreDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Health Sciences CentreFaculty of Kinesiology, University of CalgaryInflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of CalgaryDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Health Sciences CentreFaculty of Kinesiology, University of CalgaryDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Health Sciences CentreHere Kumar et al. show that increased intestinal permeability reduces hepatic de novo lipogenesis, affecting plasma membrane fluidity and lifespan of RBCs, and the resulting increase in iron levels promotes bacterial growth. This mechanism may explain the increased risk of sepsis associated with inflammatory bowel disease.https://doi.org/10.1038/s41467-019-14182-2 |
| spellingShingle | Manish Kumar Aralia Leon Coria Steve Cornick Björn Petri Shyamchand Mayengbam Humberto B. Jijon France Moreau Jane Shearer Kris Chadee Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling Nature Communications |
| title | Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling |
| title_full | Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling |
| title_fullStr | Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling |
| title_full_unstemmed | Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling |
| title_short | Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling |
| title_sort | increased intestinal permeability exacerbates sepsis through reduced hepatic scd 1 activity and dysregulated iron recycling |
| url | https://doi.org/10.1038/s41467-019-14182-2 |
| work_keys_str_mv | AT manishkumar increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling AT aralialeoncoria increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling AT stevecornick increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling AT bjornpetri increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling AT shyamchandmayengbam increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling AT humbertobjijon increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling AT francemoreau increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling AT janeshearer increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling AT krischadee increasedintestinalpermeabilityexacerbatessepsisthroughreducedhepaticscd1activityanddysregulatedironrecycling |