Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT)
Summary: Background: The Personal Activity Intelligence (PAI) translates heart rate during daily activity into a weekly score. Obtaining a weekly PAI score ≥100 is associated with reduced risk of premature morbidity and mortality from cardiovascular diseases. Here, we determined whether changes in...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | EClinicalMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537022003376 |
| _version_ | 1818483947736137728 |
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| author | Atefe R. Tari Geir Selbæk Barry A. Franklin Sverre Bergh Håvard Skjellegrind Robert E. Sallis Ingunn Bosnes Eystein Stordal Maryam Ziaei Stian Lydersen Asgeir Kobro-Flatmoen Aleksi M. Huuha Javaid Nauman Ulrik Wisløff |
| author_facet | Atefe R. Tari Geir Selbæk Barry A. Franklin Sverre Bergh Håvard Skjellegrind Robert E. Sallis Ingunn Bosnes Eystein Stordal Maryam Ziaei Stian Lydersen Asgeir Kobro-Flatmoen Aleksi M. Huuha Javaid Nauman Ulrik Wisløff |
| author_sort | Atefe R. Tari |
| collection | DOAJ |
| description | Summary: Background: The Personal Activity Intelligence (PAI) translates heart rate during daily activity into a weekly score. Obtaining a weekly PAI score ≥100 is associated with reduced risk of premature morbidity and mortality from cardiovascular diseases. Here, we determined whether changes in PAI score are associated with changes in risk of incident dementia and dementia-related mortality. Methods: We conducted a prospective cohort study of 29,826 healthy individuals. Using data from the Trøndelag Health-Study (HUNT), PAI was estimated 10 years apart (HUNT1 1984–86 and HUNT2 1995–97). Adjusted hazard-ratios (aHR) and 95%-confidence intervals (CI) for incidence of and death from dementia were related to changes in PAI using Cox regression analyses. Findings: During a median follow-up time of 24.5 years (interquartile range [IQR]: 24.1-25.0) for dementia incidence and 23.6 years (IQR: 20.8–24.2) for dementia-related mortality, there were 1998 incident cases and 1033 dementia-related deaths. Individuals who increased their PAI score over time or maintained a high PAI score at both assessments had reduced risk of dementia incidence and dementia-related mortality. Compared with persistently inactive individuals (0 weekly PAI) at both time points, the aHRs for those with a PAI score ≥100 at both occasions were 0.75 (95% CI: 0.58–0.97) for incident dementia, and 0.62 (95% CI: 0.43–0.91) for dementia-related mortality. Using PAI score <100 at both assessments as the reference cohort, those who increased from <100 at HUNT1 to ≥100 at HUNT2 had aHR of 0.83 (95% CI: 0.72–0.96) for incident dementia, and gained 2.8 (95% CI: 1.3–4.2, P<0.0001) dementia-free years. For dementia-related mortality, the corresponding aHR was 0.74 (95% CI: 0.59–0.92) and years of life gained were 2.4 (95% CI: 1.0–3.8, P=0.001). Interpretation: Maintaining a high weekly PAI score and increases in PAI scores over time were associated with a reduced risk of incident dementia and dementia-related mortality. Our findings extend the scientific evidence regarding the protective role of PA for dementia prevention, and suggest that PAI may be a valuable tool in guiding research-based PA recommendations. Funding: The Norwegian Research Council, the Liaison Committee between the Central Norway Regional Health Authority and Norwegian University of Science and Technology (NTNU), Trondheim, Norway. |
| first_indexed | 2024-12-10T15:48:44Z |
| format | Article |
| id | doaj.art-96d57a80f6ad45bb8263039896a973c6 |
| institution | Directory Open Access Journal |
| issn | 2589-5370 |
| language | English |
| last_indexed | 2024-12-10T15:48:44Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj.art-96d57a80f6ad45bb8263039896a973c62022-12-22T01:42:52ZengElsevierEClinicalMedicine2589-53702022-10-0152101607Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT)Atefe R. Tari0Geir Selbæk1Barry A. Franklin2Sverre Bergh3Håvard Skjellegrind4Robert E. Sallis5Ingunn Bosnes6Eystein Stordal7Maryam Ziaei8Stian Lydersen9Asgeir Kobro-Flatmoen10Aleksi M. Huuha11Javaid Nauman12Ulrik Wisløff13Cardiac Exercise Research Group at Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway; Department of Neurology, St. Olav's Hospital, Trondheim, NorwayNorwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway; Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway; Research Centre for Age-related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, NorwayHealthy Living for Pandemic Event Protection (HL-PIVOT) Network, Chicago, IL, USA; Preventive Cardiology and Cardiac Rehabilitation, William Beaumont Hospital, Royal Oak, MI, USA; Oakland University William Beaumont School of Medicine, Rochester, MI, USANorwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway; Research Centre for Age-related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, NorwayDepartment of Public Health and Nursing, HUNT Research Centre, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Family Medicine, Kaiser Permanente Medical Center, Fontana, CA, USAClinic for Mental Health and Substance Abuse, Namsos Hospital, Nord-Trøndelag Hospital Trust, Namsos, Norway; Department of Mental Health, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayClinic for Mental Health and Substance Abuse, Namsos Hospital, Nord-Trøndelag Hospital Trust, Namsos, Norway; Department of Mental Health, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayKavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway; Jebsen Centre for Alzheimer's Diseases, Norwegian University of Science and Technology, Trondheim, Norway; Queensland Brain Institute, University of Queensland, Brisbane, Australia.Regional Centre for Child and Youth Mental Health and Child Welfare, Norwegian University of Science and Technology, Trondheim, NorwayKavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway; Jebsen Centre for Alzheimer's Diseases, Norwegian University of Science and Technology, Trondheim, NorwayCardiac Exercise Research Group at Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway; Department of Neurology, St. Olav's Hospital, Trondheim, NorwayCardiac Exercise Research Group at Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway; Healthy Living for Pandemic Event Protection (HL-PIVOT) Network, Chicago, IL, USA; Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab EmiratesCardiac Exercise Research Group at Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway; Healthy Living for Pandemic Event Protection (HL-PIVOT) Network, Chicago, IL, USA; School of Human Movement & Nutrition Sciences, University of Queensland, Australia; Corresponding author at: Cardiac Exercise Research Group at the Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim 7491, Norway.Summary: Background: The Personal Activity Intelligence (PAI) translates heart rate during daily activity into a weekly score. Obtaining a weekly PAI score ≥100 is associated with reduced risk of premature morbidity and mortality from cardiovascular diseases. Here, we determined whether changes in PAI score are associated with changes in risk of incident dementia and dementia-related mortality. Methods: We conducted a prospective cohort study of 29,826 healthy individuals. Using data from the Trøndelag Health-Study (HUNT), PAI was estimated 10 years apart (HUNT1 1984–86 and HUNT2 1995–97). Adjusted hazard-ratios (aHR) and 95%-confidence intervals (CI) for incidence of and death from dementia were related to changes in PAI using Cox regression analyses. Findings: During a median follow-up time of 24.5 years (interquartile range [IQR]: 24.1-25.0) for dementia incidence and 23.6 years (IQR: 20.8–24.2) for dementia-related mortality, there were 1998 incident cases and 1033 dementia-related deaths. Individuals who increased their PAI score over time or maintained a high PAI score at both assessments had reduced risk of dementia incidence and dementia-related mortality. Compared with persistently inactive individuals (0 weekly PAI) at both time points, the aHRs for those with a PAI score ≥100 at both occasions were 0.75 (95% CI: 0.58–0.97) for incident dementia, and 0.62 (95% CI: 0.43–0.91) for dementia-related mortality. Using PAI score <100 at both assessments as the reference cohort, those who increased from <100 at HUNT1 to ≥100 at HUNT2 had aHR of 0.83 (95% CI: 0.72–0.96) for incident dementia, and gained 2.8 (95% CI: 1.3–4.2, P<0.0001) dementia-free years. For dementia-related mortality, the corresponding aHR was 0.74 (95% CI: 0.59–0.92) and years of life gained were 2.4 (95% CI: 1.0–3.8, P=0.001). Interpretation: Maintaining a high weekly PAI score and increases in PAI scores over time were associated with a reduced risk of incident dementia and dementia-related mortality. Our findings extend the scientific evidence regarding the protective role of PA for dementia prevention, and suggest that PAI may be a valuable tool in guiding research-based PA recommendations. Funding: The Norwegian Research Council, the Liaison Committee between the Central Norway Regional Health Authority and Norwegian University of Science and Technology (NTNU), Trondheim, Norway.http://www.sciencedirect.com/science/article/pii/S2589537022003376HUNTCardiorespiratory fitness and dementiaExercise recommendationPhysical activity recommendationsDementia and Personal Activity Intelligence |
| spellingShingle | Atefe R. Tari Geir Selbæk Barry A. Franklin Sverre Bergh Håvard Skjellegrind Robert E. Sallis Ingunn Bosnes Eystein Stordal Maryam Ziaei Stian Lydersen Asgeir Kobro-Flatmoen Aleksi M. Huuha Javaid Nauman Ulrik Wisløff Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT) EClinicalMedicine HUNT Cardiorespiratory fitness and dementia Exercise recommendation Physical activity recommendations Dementia and Personal Activity Intelligence |
| title | Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT) |
| title_full | Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT) |
| title_fullStr | Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT) |
| title_full_unstemmed | Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT) |
| title_short | Temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality: A prospective cohort study (HUNT) |
| title_sort | temporal changes in personal activity intelligence and the risk of incident dementia and dementia related mortality a prospective cohort study hunt |
| topic | HUNT Cardiorespiratory fitness and dementia Exercise recommendation Physical activity recommendations Dementia and Personal Activity Intelligence |
| url | http://www.sciencedirect.com/science/article/pii/S2589537022003376 |
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