Anti-Inflammatory and Anticancer Properties of Birch Bark-Derived Betulin: Recent Developments
Birch tree bark-derived betulin has attracted scientific interest already for several centuries, being one of the first natural products identified from plants. However, the cellular events regulated by betulin and precise molecular mechanisms under these processes have been begun to be understood o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/10/12/2663 |
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| author | Hardeep Singh Tuli Katrin Sak Dhruv Sanjay Gupta Ginpreet Kaur Diwakar Aggarwal Nidarshana Chaturvedi Parashar Renuka Choudhary Mukerrem Betul Yerer Jagjit Kaur Manoj Kumar Vivek Kumar Garg Gautam Sethi |
| author_facet | Hardeep Singh Tuli Katrin Sak Dhruv Sanjay Gupta Ginpreet Kaur Diwakar Aggarwal Nidarshana Chaturvedi Parashar Renuka Choudhary Mukerrem Betul Yerer Jagjit Kaur Manoj Kumar Vivek Kumar Garg Gautam Sethi |
| author_sort | Hardeep Singh Tuli |
| collection | DOAJ |
| description | Birch tree bark-derived betulin has attracted scientific interest already for several centuries, being one of the first natural products identified from plants. However, the cellular events regulated by betulin and precise molecular mechanisms under these processes have been begun to be understood only recently. Today, we know that betulin can exert important anticancer activities through modulation of diverse cellular pathways. In this review article, betulin-regulated molecular signaling is unraveled and presented with a special focus on its participation in anti-inflammatory processes, especially by modulating nuclear factor-κB (NF-κB), prostaglandin/COX, and nuclear factor erythroid2-related factor 2 (Nrf2)-mediated cascades. By regulating these diverse pathways, betulin can not only affect the development and progression of different cancers, but also enhance the antitumor action of traditional therapeutic modalities. It is expected that by overcoming the low bioavailability of betulin by encapsulating it into nanocarriers, this promising natural compound may provide novel possibilities for targeting inflammation-related cancers. |
| first_indexed | 2024-03-10T03:17:39Z |
| format | Article |
| id | doaj.art-96d5a04f7dcd4d39af56aec91d320440 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T03:17:39Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-96d5a04f7dcd4d39af56aec91d3204402023-11-23T10:11:22ZengMDPI AGPlants2223-77472021-12-011012266310.3390/plants10122663Anti-Inflammatory and Anticancer Properties of Birch Bark-Derived Betulin: Recent DevelopmentsHardeep Singh Tuli0Katrin Sak1Dhruv Sanjay Gupta2Ginpreet Kaur3Diwakar Aggarwal4Nidarshana Chaturvedi Parashar5Renuka Choudhary6Mukerrem Betul Yerer7Jagjit Kaur8Manoj Kumar9Vivek Kumar Garg10Gautam Sethi11Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala 133207, Haryana, IndiaNGO Praeventio, 50407 Tartu, EstoniaShobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai 40056, Maharashtra, IndiaShobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai 40056, Maharashtra, IndiaDepartment of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala 133207, Haryana, IndiaDepartment of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala 133207, Haryana, IndiaDepartment of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala 133207, Haryana, IndiaDepartment of Pharmacology, Faculty of Pharmacy, Erciyes University, Kayseri 38039, TurkeyARC Centre of Excellence in Nanoscale Biophotonics (CNBP), Graduate School of Biomedical Engineering, Faculty of Engineering, The University of New South Wales, Sydney 2052, AustraliaDepartment of Chemistry, Maharishi Markandeshwar University, Sadopur 134007, Haryana, IndiaDepartment of Medical Laboratory Technology, University Institute of Applied Health Sciences, Chandigarh University, Gharuan, Mohali 140413, Punjab, IndiaDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeBirch tree bark-derived betulin has attracted scientific interest already for several centuries, being one of the first natural products identified from plants. However, the cellular events regulated by betulin and precise molecular mechanisms under these processes have been begun to be understood only recently. Today, we know that betulin can exert important anticancer activities through modulation of diverse cellular pathways. In this review article, betulin-regulated molecular signaling is unraveled and presented with a special focus on its participation in anti-inflammatory processes, especially by modulating nuclear factor-κB (NF-κB), prostaglandin/COX, and nuclear factor erythroid2-related factor 2 (Nrf2)-mediated cascades. By regulating these diverse pathways, betulin can not only affect the development and progression of different cancers, but also enhance the antitumor action of traditional therapeutic modalities. It is expected that by overcoming the low bioavailability of betulin by encapsulating it into nanocarriers, this promising natural compound may provide novel possibilities for targeting inflammation-related cancers.https://www.mdpi.com/2223-7747/10/12/2663birch barkbetulininflammationcancerNF-κBNrf2 |
| spellingShingle | Hardeep Singh Tuli Katrin Sak Dhruv Sanjay Gupta Ginpreet Kaur Diwakar Aggarwal Nidarshana Chaturvedi Parashar Renuka Choudhary Mukerrem Betul Yerer Jagjit Kaur Manoj Kumar Vivek Kumar Garg Gautam Sethi Anti-Inflammatory and Anticancer Properties of Birch Bark-Derived Betulin: Recent Developments Plants birch bark betulin inflammation cancer NF-κB Nrf2 |
| title | Anti-Inflammatory and Anticancer Properties of Birch Bark-Derived Betulin: Recent Developments |
| title_full | Anti-Inflammatory and Anticancer Properties of Birch Bark-Derived Betulin: Recent Developments |
| title_fullStr | Anti-Inflammatory and Anticancer Properties of Birch Bark-Derived Betulin: Recent Developments |
| title_full_unstemmed | Anti-Inflammatory and Anticancer Properties of Birch Bark-Derived Betulin: Recent Developments |
| title_short | Anti-Inflammatory and Anticancer Properties of Birch Bark-Derived Betulin: Recent Developments |
| title_sort | anti inflammatory and anticancer properties of birch bark derived betulin recent developments |
| topic | birch bark betulin inflammation cancer NF-κB Nrf2 |
| url | https://www.mdpi.com/2223-7747/10/12/2663 |
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