Rodent-based aphrodisiac and toxicological evaluations of Waltheria indica ethanol root extract
Abstract Background: The root of Waltheria indica is used in Nigeria to enhance libido. This study evaluated the aphrodisiac potential and toxicological profile of ethanol root extract (EEWI) in male Wistar rats. Methods: The aphrodisiac potential was evaluated on the 7th and 14th days of oral admin...
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| Format: | Article |
| Language: | English |
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Golestan University Of Medical Sciences
2023-09-01
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| Series: | Journal of Clinical and Basic Research |
| Subjects: | |
| Online Access: | http://jcbr.goums.ac.ir/article-1-424-en.pdf |
| _version_ | 1797220414619910144 |
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| author | Ben Enoluomen Ehigiator Raymond Iduojemu Ozolua Emmar Elohor Okpakpor |
| author_facet | Ben Enoluomen Ehigiator Raymond Iduojemu Ozolua Emmar Elohor Okpakpor |
| author_sort | Ben Enoluomen Ehigiator |
| collection | DOAJ |
| description | Abstract
Background: The root of Waltheria indica is used in Nigeria to enhance libido. This study evaluated the aphrodisiac potential and toxicological profile of ethanol root extract (EEWI) in male Wistar rats.
Methods: The aphrodisiac potential was evaluated on the 7th and 14th days of oral administration of graded doses (100, 200, and 400 mg/kg/day) of EEWI. Anxiolytic properties were evaluated on the 7th day, while memory retention properties were evaluated on the 14th, 21st, and 28th days. Sperm parameters, toxicological profile, and antioxidant potential were evaluated on the 28th day. The in vitro antioxidant property was also evaluated.
Results: In a dose-dependent manner, the extract increased mounting frequency and intromission frequency but significantly decreased mount and intromission latencies (p<0.001) on the 7th and 14th day of treatment. It prolonged ejaculatory latency. Anxiolytic and memory studies showed that the extract compared agreed with standards. Toxicologically, it was observed that all the doses used neither caused death nor any gross toxicological symptom. A significant increase (p<0.05) was observed in the concentrations of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX), as well as hematological parameters such as red blood cells and hemoglobin. A significant reduction in total sperm and motile sperm cell counts was observed in rats given the highest dose.
Conclusion: The extract possesses aphrodisiac action and is relatively safe. The antioxidant property may accentuate the aphrodisiac and anti-anemic use in ethnomedicine. |
| first_indexed | 2024-04-24T12:49:10Z |
| format | Article |
| id | doaj.art-96d5d6b94ead4275823b877227da6531 |
| institution | Directory Open Access Journal |
| issn | 2538-3736 |
| language | English |
| last_indexed | 2024-04-24T12:49:10Z |
| publishDate | 2023-09-01 |
| publisher | Golestan University Of Medical Sciences |
| record_format | Article |
| series | Journal of Clinical and Basic Research |
| spelling | doaj.art-96d5d6b94ead4275823b877227da65312024-04-06T10:55:07ZengGolestan University Of Medical SciencesJournal of Clinical and Basic Research2538-37362023-09-0172815Rodent-based aphrodisiac and toxicological evaluations of Waltheria indica ethanol root extractBen Enoluomen Ehigiator0Raymond Iduojemu Ozolua1Emmar Elohor Okpakpor2 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Madonna University, Nigeria Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Nigeria Department of Science Laboratory Technology, Faculty of Life Sciences, University of Benin, Nigeria Abstract Background: The root of Waltheria indica is used in Nigeria to enhance libido. This study evaluated the aphrodisiac potential and toxicological profile of ethanol root extract (EEWI) in male Wistar rats. Methods: The aphrodisiac potential was evaluated on the 7th and 14th days of oral administration of graded doses (100, 200, and 400 mg/kg/day) of EEWI. Anxiolytic properties were evaluated on the 7th day, while memory retention properties were evaluated on the 14th, 21st, and 28th days. Sperm parameters, toxicological profile, and antioxidant potential were evaluated on the 28th day. The in vitro antioxidant property was also evaluated. Results: In a dose-dependent manner, the extract increased mounting frequency and intromission frequency but significantly decreased mount and intromission latencies (p<0.001) on the 7th and 14th day of treatment. It prolonged ejaculatory latency. Anxiolytic and memory studies showed that the extract compared agreed with standards. Toxicologically, it was observed that all the doses used neither caused death nor any gross toxicological symptom. A significant increase (p<0.05) was observed in the concentrations of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX), as well as hematological parameters such as red blood cells and hemoglobin. A significant reduction in total sperm and motile sperm cell counts was observed in rats given the highest dose. Conclusion: The extract possesses aphrodisiac action and is relatively safe. The antioxidant property may accentuate the aphrodisiac and anti-anemic use in ethnomedicine.http://jcbr.goums.ac.ir/article-1-424-en.pdferectile dysfunctionsexual behaviorsantioxidantspermtoxicity |
| spellingShingle | Ben Enoluomen Ehigiator Raymond Iduojemu Ozolua Emmar Elohor Okpakpor Rodent-based aphrodisiac and toxicological evaluations of Waltheria indica ethanol root extract Journal of Clinical and Basic Research erectile dysfunction sexual behaviors antioxidant sperm toxicity |
| title | Rodent-based aphrodisiac and toxicological evaluations of Waltheria indica ethanol root extract |
| title_full | Rodent-based aphrodisiac and toxicological evaluations of Waltheria indica ethanol root extract |
| title_fullStr | Rodent-based aphrodisiac and toxicological evaluations of Waltheria indica ethanol root extract |
| title_full_unstemmed | Rodent-based aphrodisiac and toxicological evaluations of Waltheria indica ethanol root extract |
| title_short | Rodent-based aphrodisiac and toxicological evaluations of Waltheria indica ethanol root extract |
| title_sort | rodent based aphrodisiac and toxicological evaluations of waltheria indica ethanol root extract |
| topic | erectile dysfunction sexual behaviors antioxidant sperm toxicity |
| url | http://jcbr.goums.ac.ir/article-1-424-en.pdf |
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