Human primitive mesenchymal stem cell-derived retinal progenitor cells improved neuroprotection, neurogenesis, and vision in rd12 mouse model of retinitis pigmentosa

Human primitive mesenchymal stem cell-derived retinal progenitor cells improved neuroprotection, neurogenesis, and vision in rd12 mouse model of retinitis pigmentosa

Abstract Background Currently, there is no treatment for retinal degenerative diseases (RDD) such as retinitis pigmentosa (RP). Stem cell-based therapies could provide promising opportunities to repair the damaged retina and restore vision. Thus far, primarily adult mesenchymal stem cells (MSCs) hav...

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Bibliographic Details
Main Authors: Christina Brown, Patrina Agosta, Christina McKee, Keegan Walker, Matteo Mazzella, Ali Alamri, David Svinarich, G. Rasul Chaudhry
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Stem Cell Research & Therapy
Subjects:
Retinitis pigmentosa
Retinal degenerative diseases
Retinal progenitor cells
Neuroprotection
Neurogenesis
Online Access:https://doi.org/10.1186/s13287-022-02828-w

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