The effect of breathing hypoxic gas (15% FIO2) on physiological and behavioral outcomes during simulated driving in healthy subjects
Abstract Hypoxia is mainly caused by cardiopulmonary disease or high‐altitude exposure. We used a driving simulator to investigate whether breathing hypoxic gas influences driving behaviors in healthy subjects. Fifty‐two healthy subjects were recruited in this study, approved by the Science and Engi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.15963 |
| _version_ | 1797262588625551360 |
|---|---|
| author | Jaspreet Kaur Lebbathana Manokaran Michael Thynne Mirza M. F. Subhan |
| author_facet | Jaspreet Kaur Lebbathana Manokaran Michael Thynne Mirza M. F. Subhan |
| author_sort | Jaspreet Kaur |
| collection | DOAJ |
| description | Abstract Hypoxia is mainly caused by cardiopulmonary disease or high‐altitude exposure. We used a driving simulator to investigate whether breathing hypoxic gas influences driving behaviors in healthy subjects. Fifty‐two healthy subjects were recruited in this study, approved by the Science and Engineering Ethical Committee. During simulated driving experiments, driving behaviors, breathing frequency, oxygen saturation (SpO2), and heart rate variability (HRV) were analyzed. Each subject had four driving sessions; a 10‐min practice and three 20‐min randomized interventions: normoxic room air (21% FIO2) and medical air (21% FIO2) and hypoxic air (equal to 15% FIO2), analyzed by repeated measures ANOVA. Driving behaviors and HRV frequency domains showed no significant change. Heart rate (HR; p < 0.0001), standard deviation of the RR interval (SDRR; p = 0.03), short‐term HRV (SD1; p < 0.0001), breathing rate (p = 0.01), and SpO2 (p < 0.0001) were all significantly different over the three gas interventions. Pairwise comparisons showed HR increased during hypoxic gas exposure compared to both normoxic interventions, while SDRR, SD1, breathing rate, and SpO2 were lower. Breathing hypoxic gas (15% FiO2, equivalent to 2710 m altitude) may not have a significant impact on driving behavior in healthy subjects. Furthermore, HRV was negatively affected by hypoxic gas exposure while driving suggesting further research to investigate the impact of breathing hypoxic gas on driving performance for patients with autonomic dysfunction. |
| first_indexed | 2024-04-24T23:59:30Z |
| format | Article |
| id | doaj.art-96d8d64f48214848a04934452e0511cb |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-04-24T23:59:30Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-96d8d64f48214848a04934452e0511cb2024-03-14T08:20:44ZengWileyPhysiological Reports2051-817X2024-03-01125n/an/a10.14814/phy2.15963The effect of breathing hypoxic gas (15% FIO2) on physiological and behavioral outcomes during simulated driving in healthy subjectsJaspreet Kaur0Lebbathana Manokaran1Michael Thynne2Mirza M. F. Subhan3School of Biomedical Sciences, Faculty of Health University of Plymouth Plymouth UKSchool of Biomedical Sciences, Faculty of Health University of Plymouth Plymouth UKChest Clinic University Hospitals Plymouth NHS Trust Plymouth UKSchool of Biomedical Sciences, Faculty of Health University of Plymouth Plymouth UKAbstract Hypoxia is mainly caused by cardiopulmonary disease or high‐altitude exposure. We used a driving simulator to investigate whether breathing hypoxic gas influences driving behaviors in healthy subjects. Fifty‐two healthy subjects were recruited in this study, approved by the Science and Engineering Ethical Committee. During simulated driving experiments, driving behaviors, breathing frequency, oxygen saturation (SpO2), and heart rate variability (HRV) were analyzed. Each subject had four driving sessions; a 10‐min practice and three 20‐min randomized interventions: normoxic room air (21% FIO2) and medical air (21% FIO2) and hypoxic air (equal to 15% FIO2), analyzed by repeated measures ANOVA. Driving behaviors and HRV frequency domains showed no significant change. Heart rate (HR; p < 0.0001), standard deviation of the RR interval (SDRR; p = 0.03), short‐term HRV (SD1; p < 0.0001), breathing rate (p = 0.01), and SpO2 (p < 0.0001) were all significantly different over the three gas interventions. Pairwise comparisons showed HR increased during hypoxic gas exposure compared to both normoxic interventions, while SDRR, SD1, breathing rate, and SpO2 were lower. Breathing hypoxic gas (15% FiO2, equivalent to 2710 m altitude) may not have a significant impact on driving behavior in healthy subjects. Furthermore, HRV was negatively affected by hypoxic gas exposure while driving suggesting further research to investigate the impact of breathing hypoxic gas on driving performance for patients with autonomic dysfunction.https://doi.org/10.14814/phy2.15963driving behaviorhealthy subjectsheart rate variabilityhypoxiahypoxic gasstimulated driving performance |
| spellingShingle | Jaspreet Kaur Lebbathana Manokaran Michael Thynne Mirza M. F. Subhan The effect of breathing hypoxic gas (15% FIO2) on physiological and behavioral outcomes during simulated driving in healthy subjects Physiological Reports driving behavior healthy subjects heart rate variability hypoxia hypoxic gas stimulated driving performance |
| title | The effect of breathing hypoxic gas (15% FIO2) on physiological and behavioral outcomes during simulated driving in healthy subjects |
| title_full | The effect of breathing hypoxic gas (15% FIO2) on physiological and behavioral outcomes during simulated driving in healthy subjects |
| title_fullStr | The effect of breathing hypoxic gas (15% FIO2) on physiological and behavioral outcomes during simulated driving in healthy subjects |
| title_full_unstemmed | The effect of breathing hypoxic gas (15% FIO2) on physiological and behavioral outcomes during simulated driving in healthy subjects |
| title_short | The effect of breathing hypoxic gas (15% FIO2) on physiological and behavioral outcomes during simulated driving in healthy subjects |
| title_sort | effect of breathing hypoxic gas 15 fio2 on physiological and behavioral outcomes during simulated driving in healthy subjects |
| topic | driving behavior healthy subjects heart rate variability hypoxia hypoxic gas stimulated driving performance |
| url | https://doi.org/10.14814/phy2.15963 |
| work_keys_str_mv | AT jaspreetkaur theeffectofbreathinghypoxicgas15fio2onphysiologicalandbehavioraloutcomesduringsimulateddrivinginhealthysubjects AT lebbathanamanokaran theeffectofbreathinghypoxicgas15fio2onphysiologicalandbehavioraloutcomesduringsimulateddrivinginhealthysubjects AT michaelthynne theeffectofbreathinghypoxicgas15fio2onphysiologicalandbehavioraloutcomesduringsimulateddrivinginhealthysubjects AT mirzamfsubhan theeffectofbreathinghypoxicgas15fio2onphysiologicalandbehavioraloutcomesduringsimulateddrivinginhealthysubjects AT jaspreetkaur effectofbreathinghypoxicgas15fio2onphysiologicalandbehavioraloutcomesduringsimulateddrivinginhealthysubjects AT lebbathanamanokaran effectofbreathinghypoxicgas15fio2onphysiologicalandbehavioraloutcomesduringsimulateddrivinginhealthysubjects AT michaelthynne effectofbreathinghypoxicgas15fio2onphysiologicalandbehavioraloutcomesduringsimulateddrivinginhealthysubjects AT mirzamfsubhan effectofbreathinghypoxicgas15fio2onphysiologicalandbehavioraloutcomesduringsimulateddrivinginhealthysubjects |