A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS
INTRODUCTION: The evolution of virulence in host-parasite relationships has been the subject of several publications. In the case of HIV virulence, some authors suggest that the evolution of HIV virulence correlates with the rate of acquisition of new sexual partners. In contrast some other authors...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
1999-08-01
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| Series: | Revista de Saúde Pública |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89101999000400002&lng=en&tlng=en |
| _version_ | 1818677385724166144 |
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| author | FAB Coutinho E Massad RX Menezes MN Burattini |
| author_facet | FAB Coutinho E Massad RX Menezes MN Burattini |
| author_sort | FAB Coutinho |
| collection | DOAJ |
| description | INTRODUCTION: The evolution of virulence in host-parasite relationships has been the subject of several publications. In the case of HIV virulence, some authors suggest that the evolution of HIV virulence correlates with the rate of acquisition of new sexual partners. In contrast some other authors argue that the level of HIV virulence is independent of the sexual activity of the host population. METHODS: Provide a mathematical model for the study of the potential influence of human sexual behaviour on the evolution of virulence of HIV is provided. RESULTS: The results indicated that, when the probability of acquisition of infection is a function both of the sexual activity and of the virulence level of HIV strains, the evolution of HIV virulence correlates positively with the rate of acquisition of new sexual partners. CONCLUSION: It is concluded that in the case of a host population with a low (high) rate of exchange of sexual partners the evolution of HIV virulence is such that the less (more) virulent strain prevails. |
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| format | Article |
| id | doaj.art-96db43501c6740c7a2d11e696bdcaa6f |
| institution | Directory Open Access Journal |
| issn | 1518-8787 |
| language | English |
| last_indexed | 2024-12-17T08:58:32Z |
| publishDate | 1999-08-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Revista de Saúde Pública |
| spelling | doaj.art-96db43501c6740c7a2d11e696bdcaa6f2022-12-21T21:55:54ZengUniversidade de São PauloRevista de Saúde Pública1518-87871999-08-0133432933310.1590/s0034-89101999000400002S0034-89101999000400002A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDSFAB Coutinho0E Massad1RX Menezes2MN Burattini3Universidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloINTRODUCTION: The evolution of virulence in host-parasite relationships has been the subject of several publications. In the case of HIV virulence, some authors suggest that the evolution of HIV virulence correlates with the rate of acquisition of new sexual partners. In contrast some other authors argue that the level of HIV virulence is independent of the sexual activity of the host population. METHODS: Provide a mathematical model for the study of the potential influence of human sexual behaviour on the evolution of virulence of HIV is provided. RESULTS: The results indicated that, when the probability of acquisition of infection is a function both of the sexual activity and of the virulence level of HIV strains, the evolution of HIV virulence correlates positively with the rate of acquisition of new sexual partners. CONCLUSION: It is concluded that in the case of a host population with a low (high) rate of exchange of sexual partners the evolution of HIV virulence is such that the less (more) virulent strain prevails.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89101999000400002&lng=en&tlng=enSíndrome de Imunodeficiência AdquiridaVirulênciaModelos estatísticos |
| spellingShingle | FAB Coutinho E Massad RX Menezes MN Burattini A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS Revista de Saúde Pública Síndrome de Imunodeficiência Adquirida Virulência Modelos estatísticos |
| title | A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS |
| title_full | A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS |
| title_fullStr | A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS |
| title_full_unstemmed | A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS |
| title_short | A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS |
| title_sort | theoretical model of the evolution of virulence in sexually transmitted hiv aids |
| topic | Síndrome de Imunodeficiência Adquirida Virulência Modelos estatísticos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89101999000400002&lng=en&tlng=en |
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