THE CONTENT OF MCP-1 AND MMP-9 IN BLOOD SERUM OF PATIENTS WITH CHRONIC POLYPOID RHINOSINUSITIS
The content of MCP-1 and MMP-9 inblood serum of patients with chronic polypoid rhinosinusitis was studied. It was found that this pathology led to a significant increase in MCP-1, which is a marker of fibrosis, in blood serum. The compensatory increase in MMP-9, serving as an antifibrotic factor, is...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
V. N. Karazin Kharkiv National University
2017-06-01
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| Series: | Journal of V. N. Karazin Kharkiv National University: Series Medicine |
| Online Access: | http://periodicals.karazin.ua/medicine/article/view/9135/8654 |
| Summary: | The content of MCP-1 and MMP-9 inblood serum of patients with chronic polypoid rhinosinusitis was studied. It was found that this pathology led to a significant increase in MCP-1, which is a marker of fibrosis, in blood serum. The compensatory increase in MMP-9, serving as an antifibrotic factor, is much weaker. Such imbalance between profibrotic MCP-1 and antifibrotic MMP-9 indicates a lack of compensatory adaptation mechanisms of fibrolysis activation and contributes to the development of fibrosis in chronic polypoid rhinosinusitis. |
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| ISSN: | 2313-6693 2313-2396 |