Platelets and Metastasis: New Implications of an Old Interplay
During the process of hematogenous metastasis, tumor cells interact with platelets and their precursors megakaryocytes, providing a selection driver for the metastatic phenotype. Cancer cells have evolved a plethora of mechanisms to engage platelet activation and aggregation. Platelet coating of tum...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.01350/full |
| _version_ | 1819020135609925632 |
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| author | Serena Lucotti Ruth J. Muschel |
| author_facet | Serena Lucotti Ruth J. Muschel |
| author_sort | Serena Lucotti |
| collection | DOAJ |
| description | During the process of hematogenous metastasis, tumor cells interact with platelets and their precursors megakaryocytes, providing a selection driver for the metastatic phenotype. Cancer cells have evolved a plethora of mechanisms to engage platelet activation and aggregation. Platelet coating of tumor cells in the blood stream promotes the successful completion of multiple steps of the metastatic cascade. Along the same lines, clinical evidence suggests that anti-coagulant therapy might be associated with reduced risk of metastatic disease and better prognosis in cancer patients. Here, we review experimental and clinical literature concerning the contribution of platelets and megakaryocytes to cancer metastasis and provide insights into the clinical relevance of anti-coagulant therapy in cancer treatment. |
| first_indexed | 2024-12-21T03:46:24Z |
| format | Article |
| id | doaj.art-96dc66604db14da88820f8402b0d98e6 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T03:46:24Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-96dc66604db14da88820f8402b0d98e62022-12-21T19:17:04ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-09-011010.3389/fonc.2020.01350552385Platelets and Metastasis: New Implications of an Old InterplaySerena Lucotti0Ruth J. Muschel1Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, United StatesCancer Research UK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United KingdomDuring the process of hematogenous metastasis, tumor cells interact with platelets and their precursors megakaryocytes, providing a selection driver for the metastatic phenotype. Cancer cells have evolved a plethora of mechanisms to engage platelet activation and aggregation. Platelet coating of tumor cells in the blood stream promotes the successful completion of multiple steps of the metastatic cascade. Along the same lines, clinical evidence suggests that anti-coagulant therapy might be associated with reduced risk of metastatic disease and better prognosis in cancer patients. Here, we review experimental and clinical literature concerning the contribution of platelets and megakaryocytes to cancer metastasis and provide insights into the clinical relevance of anti-coagulant therapy in cancer treatment.https://www.frontiersin.org/article/10.3389/fonc.2020.01350/fullplateletsmegakaryocytescancer metastasiscoagulationanti-coagulant therapythromboembolism |
| spellingShingle | Serena Lucotti Ruth J. Muschel Platelets and Metastasis: New Implications of an Old Interplay Frontiers in Oncology platelets megakaryocytes cancer metastasis coagulation anti-coagulant therapy thromboembolism |
| title | Platelets and Metastasis: New Implications of an Old Interplay |
| title_full | Platelets and Metastasis: New Implications of an Old Interplay |
| title_fullStr | Platelets and Metastasis: New Implications of an Old Interplay |
| title_full_unstemmed | Platelets and Metastasis: New Implications of an Old Interplay |
| title_short | Platelets and Metastasis: New Implications of an Old Interplay |
| title_sort | platelets and metastasis new implications of an old interplay |
| topic | platelets megakaryocytes cancer metastasis coagulation anti-coagulant therapy thromboembolism |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.01350/full |
| work_keys_str_mv | AT serenalucotti plateletsandmetastasisnewimplicationsofanoldinterplay AT ruthjmuschel plateletsandmetastasisnewimplicationsofanoldinterplay |