Uterine choriocarcinoma arising from serous carcinoma in a postmenopausal woman: an analysis of next-generation sequencing and PD-L1 immunochemistry
Abstract Background Uterine somatic choriocarcinoma is a rare, clinically aggressive malignant tumor. They frequently concur with other cancer. However, the molecular pathogenesis between somatic choriocarcinoma and the concurrent carcinoma has rarely been addressed to date. Case presentation We rep...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Diagnostic Pathology |
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| Online Access: | https://doi.org/10.1186/s13000-022-01262-z |
| _version_ | 1798029940354973696 |
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| author | Meiping Li Lei Bao Bo Lu Wenshun Ge Lifang Ren |
| author_facet | Meiping Li Lei Bao Bo Lu Wenshun Ge Lifang Ren |
| author_sort | Meiping Li |
| collection | DOAJ |
| description | Abstract Background Uterine somatic choriocarcinoma is a rare, clinically aggressive malignant tumor. They frequently concur with other cancer. However, the molecular pathogenesis between somatic choriocarcinoma and the concurrent carcinoma has rarely been addressed to date. Case presentation We report a 68-years old Chinese woman with a uterine choriocarcinoma arising from serous carcinoma. The patient underwent radical surgery including total abdominal hysterectomy with bilateral salpingo-oophorectomy, omentectomy and pelvic lymph node resection. She received 10 courses of post-operative chemotherapy. She died of disease 13 months after her surgery. Microscopically, the tumor showed a biphasic pattern of choriocarcinoma and serous carcinoma. The choriocarcinomatous component showed a combination of cytotrophoblast, intermediate trophoblast and syncytiotrophoblast with hemorrhage and necrosis. The component of serous carcinoma was characterized by solid sheets of small cells with marked nuclear atypia and occasional glandular and papillary formation. PD-L1 was exclusively expressed in the choriocarcinomatous component. Next-generation sequencing revealed that the genetic abnormalities were overlapping between the two components. |
| first_indexed | 2024-04-11T19:33:10Z |
| format | Article |
| id | doaj.art-96de3ce868fc4456b72eb40b24521496 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-04-11T19:33:10Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-96de3ce868fc4456b72eb40b245214962022-12-22T04:06:57ZengBMCDiagnostic Pathology1746-15962022-10-011711610.1186/s13000-022-01262-zUterine choriocarcinoma arising from serous carcinoma in a postmenopausal woman: an analysis of next-generation sequencing and PD-L1 immunochemistryMeiping Li0Lei Bao1Bo Lu2Wenshun Ge3Lifang Ren4Department of Surgical Pathology, Shaoxing Maternity and Child Health Care HospitalDepartment of Surgical Pathology, Shaoxing Maternity and Child Health Care HospitalDepartment of Surgical Pathology, Shaoxing Maternity and Child Health Care HospitalDepartment of Surgical Pathology, Shaoxing Maternity and Child Health Care HospitalDepartment of Surgical Pathology, Shaoxing Maternity and Child Health Care HospitalAbstract Background Uterine somatic choriocarcinoma is a rare, clinically aggressive malignant tumor. They frequently concur with other cancer. However, the molecular pathogenesis between somatic choriocarcinoma and the concurrent carcinoma has rarely been addressed to date. Case presentation We report a 68-years old Chinese woman with a uterine choriocarcinoma arising from serous carcinoma. The patient underwent radical surgery including total abdominal hysterectomy with bilateral salpingo-oophorectomy, omentectomy and pelvic lymph node resection. She received 10 courses of post-operative chemotherapy. She died of disease 13 months after her surgery. Microscopically, the tumor showed a biphasic pattern of choriocarcinoma and serous carcinoma. The choriocarcinomatous component showed a combination of cytotrophoblast, intermediate trophoblast and syncytiotrophoblast with hemorrhage and necrosis. The component of serous carcinoma was characterized by solid sheets of small cells with marked nuclear atypia and occasional glandular and papillary formation. PD-L1 was exclusively expressed in the choriocarcinomatous component. Next-generation sequencing revealed that the genetic abnormalities were overlapping between the two components.https://doi.org/10.1186/s13000-022-01262-zChoriocarcinomaEndometriumSerous carcinomaPD-L1Next-generation sequencing |
| spellingShingle | Meiping Li Lei Bao Bo Lu Wenshun Ge Lifang Ren Uterine choriocarcinoma arising from serous carcinoma in a postmenopausal woman: an analysis of next-generation sequencing and PD-L1 immunochemistry Diagnostic Pathology Choriocarcinoma Endometrium Serous carcinoma PD-L1 Next-generation sequencing |
| title | Uterine choriocarcinoma arising from serous carcinoma in a postmenopausal woman: an analysis of next-generation sequencing and PD-L1 immunochemistry |
| title_full | Uterine choriocarcinoma arising from serous carcinoma in a postmenopausal woman: an analysis of next-generation sequencing and PD-L1 immunochemistry |
| title_fullStr | Uterine choriocarcinoma arising from serous carcinoma in a postmenopausal woman: an analysis of next-generation sequencing and PD-L1 immunochemistry |
| title_full_unstemmed | Uterine choriocarcinoma arising from serous carcinoma in a postmenopausal woman: an analysis of next-generation sequencing and PD-L1 immunochemistry |
| title_short | Uterine choriocarcinoma arising from serous carcinoma in a postmenopausal woman: an analysis of next-generation sequencing and PD-L1 immunochemistry |
| title_sort | uterine choriocarcinoma arising from serous carcinoma in a postmenopausal woman an analysis of next generation sequencing and pd l1 immunochemistry |
| topic | Choriocarcinoma Endometrium Serous carcinoma PD-L1 Next-generation sequencing |
| url | https://doi.org/10.1186/s13000-022-01262-z |
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