Runx1t1 promotes the neuronal differentiation in rat hippocampus
Abstract Background Runt-related transcription factor 1 translocated to 1 (Runx1t1) is one of the members of the myeloid translocation gene family. Our previous work showed that Runx1t1 induced the neuronal differentiation of radial glia cells in vitro. Methods To better uncover the role of Runx1t1...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13287-020-01667-x |
| _version_ | 1817994977192443904 |
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| author | Linqing Zou Haoming Li Xiao Han Jianbing Qin Guoqi Song |
| author_facet | Linqing Zou Haoming Li Xiao Han Jianbing Qin Guoqi Song |
| author_sort | Linqing Zou |
| collection | DOAJ |
| description | Abstract Background Runt-related transcription factor 1 translocated to 1 (Runx1t1) is one of the members of the myeloid translocation gene family. Our previous work showed that Runx1t1 induced the neuronal differentiation of radial glia cells in vitro. Methods To better uncover the role of Runx1t1 in hippocampal neurogenesis, in this study, we further explore its localization and function during the hippocampal neurogenesis. Results Our results showed that insufficient expression of Runx1t1 reduced the neuronal differentiation, and overexpression of Runx1t1 promoted the neuronal differentiation in vitro. We also found that Runx1t1 localized in neurons but not astrocytes both in vivo and in vitro. Furthermore, we found that Runx1t1 overexpression elevated the number of newborn neurons in the hippocampal dentate gyrus. Conclusions Taken together, our results further proved that Runx1t1 could be worked as a regulator in the process of hippocampal neurogenesis. |
| first_indexed | 2024-04-14T02:00:17Z |
| format | Article |
| id | doaj.art-96decc2905ad4dc38a5c08757767e8a9 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-14T02:00:17Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-96decc2905ad4dc38a5c08757767e8a92022-12-22T02:18:52ZengBMCStem Cell Research & Therapy1757-65122020-04-0111111010.1186/s13287-020-01667-xRunx1t1 promotes the neuronal differentiation in rat hippocampusLinqing Zou0Haoming Li1Xiao Han2Jianbing Qin3Guoqi Song4Department of Human Anatomy, Jiangsu Key Laboratory of Neuroregeneration, Nantong UniversityDepartment of Human Anatomy, Jiangsu Key Laboratory of Neuroregeneration, Nantong UniversityDepartment of Human Anatomy, Jiangsu Key Laboratory of Neuroregeneration, Nantong UniversityDepartment of Human Anatomy, Jiangsu Key Laboratory of Neuroregeneration, Nantong UniversityDepartment of Hematology, Affiliated Hospital of Nantong UniversityAbstract Background Runt-related transcription factor 1 translocated to 1 (Runx1t1) is one of the members of the myeloid translocation gene family. Our previous work showed that Runx1t1 induced the neuronal differentiation of radial glia cells in vitro. Methods To better uncover the role of Runx1t1 in hippocampal neurogenesis, in this study, we further explore its localization and function during the hippocampal neurogenesis. Results Our results showed that insufficient expression of Runx1t1 reduced the neuronal differentiation, and overexpression of Runx1t1 promoted the neuronal differentiation in vitro. We also found that Runx1t1 localized in neurons but not astrocytes both in vivo and in vitro. Furthermore, we found that Runx1t1 overexpression elevated the number of newborn neurons in the hippocampal dentate gyrus. Conclusions Taken together, our results further proved that Runx1t1 could be worked as a regulator in the process of hippocampal neurogenesis.http://link.springer.com/article/10.1186/s13287-020-01667-xRunx1t1HippocampusNeural stem cellsNeuronDifferentiationNeurogenesis |
| spellingShingle | Linqing Zou Haoming Li Xiao Han Jianbing Qin Guoqi Song Runx1t1 promotes the neuronal differentiation in rat hippocampus Stem Cell Research & Therapy Runx1t1 Hippocampus Neural stem cells Neuron Differentiation Neurogenesis |
| title | Runx1t1 promotes the neuronal differentiation in rat hippocampus |
| title_full | Runx1t1 promotes the neuronal differentiation in rat hippocampus |
| title_fullStr | Runx1t1 promotes the neuronal differentiation in rat hippocampus |
| title_full_unstemmed | Runx1t1 promotes the neuronal differentiation in rat hippocampus |
| title_short | Runx1t1 promotes the neuronal differentiation in rat hippocampus |
| title_sort | runx1t1 promotes the neuronal differentiation in rat hippocampus |
| topic | Runx1t1 Hippocampus Neural stem cells Neuron Differentiation Neurogenesis |
| url | http://link.springer.com/article/10.1186/s13287-020-01667-x |
| work_keys_str_mv | AT linqingzou runx1t1promotestheneuronaldifferentiationinrathippocampus AT haomingli runx1t1promotestheneuronaldifferentiationinrathippocampus AT xiaohan runx1t1promotestheneuronaldifferentiationinrathippocampus AT jianbingqin runx1t1promotestheneuronaldifferentiationinrathippocampus AT guoqisong runx1t1promotestheneuronaldifferentiationinrathippocampus |