Mechanical stress shapes the cancer cell response to neddylation inhibition

Mechanical stress shapes the cancer cell response to neddylation inhibition

Abstract Background The inhibition of neddylation by the preclinical drug MLN4924 represents a new strategy to combat cancer. However, despite being effective against hematologic malignancies, its success in solid tumors, where cell–cell and cell-ECM interactions play essential roles, remains elusiv...

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Bibliographic Details
Main Authors: Frédérique Mittler, Patricia Obeïd, Vincent Haguet, Cédric Allier, Sophie Gerbaud, Anastasia V. Rulina, Xavier Gidrol, Maxim Y. Balakirev
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
MLN4924
Rho GTPases
Mechanical stress
Tight junctions
Metastasis
Prostate cancer
Online Access:https://doi.org/10.1186/s13046-022-02328-y

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