Exploring the Surge in Paediatric Type 2 Diabetes in an Inner-City London Centre—A Decade-Long Analysis of Incidence, Outcomes, and Transition
The rising prevalence of paediatric type 2 diabetes (T2D) is concerning, particularly with limited medical intervention despite evidence of accelerated disease progression. This study of a Barts Health NHS Trust cohort from 2008 to 2022 aims to elucidate the incidence, clinical outcomes, and complic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/11/2/173 |
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| author | Farah Abdelhameed Anna Giuffrida Ben Thorp Myuri K. Moorthy Evelien F. Gevers |
| author_facet | Farah Abdelhameed Anna Giuffrida Ben Thorp Myuri K. Moorthy Evelien F. Gevers |
| author_sort | Farah Abdelhameed |
| collection | DOAJ |
| description | The rising prevalence of paediatric type 2 diabetes (T2D) is concerning, particularly with limited medical intervention despite evidence of accelerated disease progression. This study of a Barts Health NHS Trust cohort from 2008 to 2022 aims to elucidate the incidence, clinical outcomes, and complications associated with paediatric T2D. A retrospective analysis utilising electronic and paper records identified 40 patients with T2D. The incidence doubled from 2.6/year in 2008–2013 to 5.4/year in 2014–2018. Sixty-eight percent exhibited co-morbidities, notably learning disabilities. At diagnosis, the mean BMI was 32.4 ± 6.71 kg/m<sup>2</sup>, with no gender-based disparity and no significant change over a two-year follow-up. The initial HbA1c was 75.2 ± 21.0 mmol/mol, decreasing to 55.0 ± 17.4 mmol/mol after three months (<i>p</i> = 0.001) and then rising to 63.0 ± 25.5 mmol/mol at one year (<i>p</i> = 0.07). While 22/37 patients achieved HbA1c < 48 mmol/mol, only 9 maintained this for a year. Several metabolic and cardiovascular complications were observed at diagnosis and follow-up, with no significant change in frequency. In 2022, 15 patients transitioned to adult services. HbA1c at transition was 74.7 ± 27.6 mmol/mol, showing no change one year post-transition (71.9 ± 26.9 mmol/mol, <i>p</i> = 0.34). This study highlights substantial therapeutic failure, with current management falling short in achieving a sustained reduction in BMI or HbA1c. Novel treatment approaches are needed to improve clinical outcomes and address the high burden of co-morbidities and complications. |
| first_indexed | 2024-03-07T22:37:50Z |
| format | Article |
| id | doaj.art-96e0c760cbe047e1b144d48e45dfefb3 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-07T22:37:50Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-96e0c760cbe047e1b144d48e45dfefb32024-02-23T15:12:16ZengMDPI AGChildren2227-90672024-01-0111217310.3390/children11020173Exploring the Surge in Paediatric Type 2 Diabetes in an Inner-City London Centre—A Decade-Long Analysis of Incidence, Outcomes, and TransitionFarah Abdelhameed0Anna Giuffrida1Ben Thorp2Myuri K. Moorthy3Evelien F. Gevers4Barts Health NHS Trust—Royal London Children’s Hospital, London E1 1BB, UKBarts Health NHS Trust—Royal London Children’s Hospital, London E1 1BB, UKBarts Health NHS Trust—Royal London Children’s Hospital, London E1 1BB, UKBarts Health NHS Trust—Royal London Children’s Hospital, London E1 1BB, UKBarts Health NHS Trust—Royal London Children’s Hospital, London E1 1BB, UKThe rising prevalence of paediatric type 2 diabetes (T2D) is concerning, particularly with limited medical intervention despite evidence of accelerated disease progression. This study of a Barts Health NHS Trust cohort from 2008 to 2022 aims to elucidate the incidence, clinical outcomes, and complications associated with paediatric T2D. A retrospective analysis utilising electronic and paper records identified 40 patients with T2D. The incidence doubled from 2.6/year in 2008–2013 to 5.4/year in 2014–2018. Sixty-eight percent exhibited co-morbidities, notably learning disabilities. At diagnosis, the mean BMI was 32.4 ± 6.71 kg/m<sup>2</sup>, with no gender-based disparity and no significant change over a two-year follow-up. The initial HbA1c was 75.2 ± 21.0 mmol/mol, decreasing to 55.0 ± 17.4 mmol/mol after three months (<i>p</i> = 0.001) and then rising to 63.0 ± 25.5 mmol/mol at one year (<i>p</i> = 0.07). While 22/37 patients achieved HbA1c < 48 mmol/mol, only 9 maintained this for a year. Several metabolic and cardiovascular complications were observed at diagnosis and follow-up, with no significant change in frequency. In 2022, 15 patients transitioned to adult services. HbA1c at transition was 74.7 ± 27.6 mmol/mol, showing no change one year post-transition (71.9 ± 26.9 mmol/mol, <i>p</i> = 0.34). This study highlights substantial therapeutic failure, with current management falling short in achieving a sustained reduction in BMI or HbA1c. Novel treatment approaches are needed to improve clinical outcomes and address the high burden of co-morbidities and complications.https://www.mdpi.com/2227-9067/11/2/173paediatric type 2 diabetescomplicationssingle-centre cohortyouthobesity |
| spellingShingle | Farah Abdelhameed Anna Giuffrida Ben Thorp Myuri K. Moorthy Evelien F. Gevers Exploring the Surge in Paediatric Type 2 Diabetes in an Inner-City London Centre—A Decade-Long Analysis of Incidence, Outcomes, and Transition Children paediatric type 2 diabetes complications single-centre cohort youth obesity |
| title | Exploring the Surge in Paediatric Type 2 Diabetes in an Inner-City London Centre—A Decade-Long Analysis of Incidence, Outcomes, and Transition |
| title_full | Exploring the Surge in Paediatric Type 2 Diabetes in an Inner-City London Centre—A Decade-Long Analysis of Incidence, Outcomes, and Transition |
| title_fullStr | Exploring the Surge in Paediatric Type 2 Diabetes in an Inner-City London Centre—A Decade-Long Analysis of Incidence, Outcomes, and Transition |
| title_full_unstemmed | Exploring the Surge in Paediatric Type 2 Diabetes in an Inner-City London Centre—A Decade-Long Analysis of Incidence, Outcomes, and Transition |
| title_short | Exploring the Surge in Paediatric Type 2 Diabetes in an Inner-City London Centre—A Decade-Long Analysis of Incidence, Outcomes, and Transition |
| title_sort | exploring the surge in paediatric type 2 diabetes in an inner city london centre a decade long analysis of incidence outcomes and transition |
| topic | paediatric type 2 diabetes complications single-centre cohort youth obesity |
| url | https://www.mdpi.com/2227-9067/11/2/173 |
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