Role of the Skin Microenvironment in Melanomagenesis: Epidermal Keratinocytes and Dermal Fibroblasts Promote BRAF Oncogene-Induced Senescence Escape in Melanocytes

Role of the Skin Microenvironment in Melanomagenesis: Epidermal Keratinocytes and Dermal Fibroblasts Promote BRAF Oncogene-Induced Senescence Escape in Melanocytes

<i>BRAF<sup>V600E</sup></i> is the most common mutation driver in melanoma. This mutation is known to cause a brief burst of proliferation followed by growth arrest and senescence, which prevent an uncontrolled cell proliferation. This phenomenon is known as oncogene-induced...

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Bibliographic Details
Main Authors: Shreyans Sadangi, Katarina Milosavljevic, Edgardo Castro-Perez, Marcos Lares, Mithalesh Singh, Sarah Altameemi, David J. Beebe, Jose M. Ayuso, Vijayasaradhi Setaluri
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
melanoma
tumor microenvironment
senescence
microfluidics
Online Access:https://www.mdpi.com/2072-6694/14/5/1233

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