Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia
A high prevalence of vitamin D deficiency has been reported in Malaysian pregnant women, indicating that neonates at birth are at increased risk of vitamin D deficiency. Factors including low dietary vitamin D intake and single nucleotide polymorphisms in the vitamin D metabolism genes have been ass...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Human Nutrition & Metabolism |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666149724000215 |
| _version_ | 1797261853004398592 |
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| author | Siew-Siew Lee King-Hwa Ling Raman Subramaniam Maiza Tusimin Kartini Farah Rahim Su-Peng Loh |
| author_facet | Siew-Siew Lee King-Hwa Ling Raman Subramaniam Maiza Tusimin Kartini Farah Rahim Su-Peng Loh |
| author_sort | Siew-Siew Lee |
| collection | DOAJ |
| description | A high prevalence of vitamin D deficiency has been reported in Malaysian pregnant women, indicating that neonates at birth are at increased risk of vitamin D deficiency. Factors including low dietary vitamin D intake and single nucleotide polymorphisms in the vitamin D metabolism genes have been associated with this deficiency in the population. However, there was limited data available regarding the prevalence of neonatal vitamin D deficiency and the factors associated with it among neonates in Malaysia. Therefore, this study aimed to determine the prevalence of vitamin D deficiency and explore the associations between maternal and neonatal gene polymorphisms, as well as non-genetic factors and neonatal vitamin D deficiency. A total of 217 mother-neonate dyads were recruited for this study. Data on skin type, maternal sun exposure, dietary intake, as well as maternal and neonatal 25-hydroxyvitamin D (25OHD) concentrations were collected. Maternal and neonatal vitamin D Receptor (VDR) SNP (rs2228570) and Group-specific component (GC) SNPs (rs4588 and rs7041) genotypes were determined using high-resolution melting (HRM) and restriction fragment length polymorphism, respectively. The results showed that 60.4%, 71.4% and 95.4% of neonates had cord blood 25OHD levels below 25 nmol/L, 30 nmol/L and 50 nmol/L, respectively. After adjusting for the maternal vitamin D status, the maternal VDR rs2228570 GG genotype was significantly associated with neonatal vitamin D deficiency (25OHD<30 nmol/L) (aOR = 2.63, 95% CI: 1.18–5.87, p = 0.018). Maternal vitamin D supplement intake was found to be a protective factor. However, maternal and neonatal vitamin D binding protein (VDBP) SNPs were not associated with neonatal vitamin D deficiency. The high prevalence of neonatal vitamin D deficiency reported in this study indicates the urgent need for the development and implementation of strategies to improve neonatal vitamin D status. The findings suggest that maternal supplementation may be an effective approach to enhance the vitamin D status of neonates. |
| first_indexed | 2024-04-24T23:47:49Z |
| format | Article |
| id | doaj.art-96e2d08fde50467bbe62e5b154052089 |
| institution | Directory Open Access Journal |
| issn | 2666-1497 |
| language | English |
| last_indexed | 2024-04-24T23:47:49Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Human Nutrition & Metabolism |
| spelling | doaj.art-96e2d08fde50467bbe62e5b1540520892024-03-15T04:44:37ZengElsevierHuman Nutrition & Metabolism2666-14972024-06-0136200259Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in MalaysiaSiew-Siew Lee0King-Hwa Ling1Raman Subramaniam2Maiza Tusimin3Kartini Farah Rahim4Su-Peng Loh5Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia; School of Biosciences, Faculty of Science and Engineering, University of Nottingham Malaysia, 43500 Semenyih, Selangor Darul Ehsan, MalaysiaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, MalaysiaFetal Medicine and Gynaecology Centre (FMGC), 46200 Petaling Jaya, Selangor Darul Ehsan, MalaysiaPrince Court Medical Centre, 50450 Kuala Lumpur, MalaysiaAvisena Specialist Hospital, 40000 Shah Alam, Selangor Darul Ehsan, MalaysiaDepartment of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia; Research Centre of Excellence for Nutrition and Non-Communicable Diseases, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43300 UPM Serdang, Selangor Darul Ehsan, Malaysia; Corresponding author. Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia.A high prevalence of vitamin D deficiency has been reported in Malaysian pregnant women, indicating that neonates at birth are at increased risk of vitamin D deficiency. Factors including low dietary vitamin D intake and single nucleotide polymorphisms in the vitamin D metabolism genes have been associated with this deficiency in the population. However, there was limited data available regarding the prevalence of neonatal vitamin D deficiency and the factors associated with it among neonates in Malaysia. Therefore, this study aimed to determine the prevalence of vitamin D deficiency and explore the associations between maternal and neonatal gene polymorphisms, as well as non-genetic factors and neonatal vitamin D deficiency. A total of 217 mother-neonate dyads were recruited for this study. Data on skin type, maternal sun exposure, dietary intake, as well as maternal and neonatal 25-hydroxyvitamin D (25OHD) concentrations were collected. Maternal and neonatal vitamin D Receptor (VDR) SNP (rs2228570) and Group-specific component (GC) SNPs (rs4588 and rs7041) genotypes were determined using high-resolution melting (HRM) and restriction fragment length polymorphism, respectively. The results showed that 60.4%, 71.4% and 95.4% of neonates had cord blood 25OHD levels below 25 nmol/L, 30 nmol/L and 50 nmol/L, respectively. After adjusting for the maternal vitamin D status, the maternal VDR rs2228570 GG genotype was significantly associated with neonatal vitamin D deficiency (25OHD<30 nmol/L) (aOR = 2.63, 95% CI: 1.18–5.87, p = 0.018). Maternal vitamin D supplement intake was found to be a protective factor. However, maternal and neonatal vitamin D binding protein (VDBP) SNPs were not associated with neonatal vitamin D deficiency. The high prevalence of neonatal vitamin D deficiency reported in this study indicates the urgent need for the development and implementation of strategies to improve neonatal vitamin D status. The findings suggest that maternal supplementation may be an effective approach to enhance the vitamin D status of neonates.http://www.sciencedirect.com/science/article/pii/S2666149724000215Vitamin D25-Hydroxyvitamin DNeonateSingle-nucleotide polymorphism |
| spellingShingle | Siew-Siew Lee King-Hwa Ling Raman Subramaniam Maiza Tusimin Kartini Farah Rahim Su-Peng Loh Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia Human Nutrition & Metabolism Vitamin D 25-Hydroxyvitamin D Neonate Single-nucleotide polymorphism |
| title | Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia |
| title_full | Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia |
| title_fullStr | Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia |
| title_full_unstemmed | Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia |
| title_short | Genetic variants and non-genetic factors associated with a high prevalence of vitamin D deficiency in full-term neonates in Malaysia |
| title_sort | genetic variants and non genetic factors associated with a high prevalence of vitamin d deficiency in full term neonates in malaysia |
| topic | Vitamin D 25-Hydroxyvitamin D Neonate Single-nucleotide polymorphism |
| url | http://www.sciencedirect.com/science/article/pii/S2666149724000215 |
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