Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma
A 51-year-old woman presented with severe dizziness. The brain magnetic resonance image revealed a 5.5 cm multiloculated mass with a thick rim in the left temporal lobe. Cytological examination of frozen diagnosis of the mass showed hypercellular sheets of round and rhabdoid cells in a hemorrhagic b...
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2019-05-01
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| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2019-03-20.pdf |
| _version_ | 1818476448356237312 |
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| author | Myunghee Kang Na Rae Kim Dong Hae Chung Gie-Taek Yie |
| author_facet | Myunghee Kang Na Rae Kim Dong Hae Chung Gie-Taek Yie |
| author_sort | Myunghee Kang |
| collection | DOAJ |
| description | A 51-year-old woman presented with severe dizziness. The brain magnetic resonance image revealed a 5.5 cm multiloculated mass with a thick rim in the left temporal lobe. Cytological examination of frozen diagnosis of the mass showed hypercellular sheets of round and rhabdoid cells in a hemorrhagic background, and two mitotic figures were observed. Histologically, the excised dura-based mass consisted of predominantly round cells with small foci of rhabdoid tumor cells in a pseudoalveolar pattern in a hemorrhagic background, and the cells showed nuclear positivity for signal transducer and activator of transcription 6 as well as frequent mitosis. The mass was diagnosed as a grade 3 solitary fibrous tumor (SFT)/hemangiopericytoma (HPC). The cytological diagnosis of SFT/HPC is challenging because of the heterogeneous cytological findings, such as histological heterogeneity, and because there are no standardized cytological criteria for malignant SFT/HPC. Cytological findings, such as singly scattered small cells, hypercellularity, rare ropy collagen, and round and rhabdoid cells with pseudoalveolar pattern, may assist in the diagnosis of malignant SFT/HPC. |
| first_indexed | 2024-12-10T09:25:51Z |
| format | Article |
| id | doaj.art-96e4556062c64032a5e4dfc5fdc7d6d4 |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-10T09:25:51Z |
| publishDate | 2019-05-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-96e4556062c64032a5e4dfc5fdc7d6d42022-12-22T01:54:33ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452019-05-0153319219710.4132/jptm.2019.03.2016830Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/HemangiopericytomaMyunghee KangNa Rae KimDong Hae ChungGie-Taek Yie0 Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine, Incheon, KoreaA 51-year-old woman presented with severe dizziness. The brain magnetic resonance image revealed a 5.5 cm multiloculated mass with a thick rim in the left temporal lobe. Cytological examination of frozen diagnosis of the mass showed hypercellular sheets of round and rhabdoid cells in a hemorrhagic background, and two mitotic figures were observed. Histologically, the excised dura-based mass consisted of predominantly round cells with small foci of rhabdoid tumor cells in a pseudoalveolar pattern in a hemorrhagic background, and the cells showed nuclear positivity for signal transducer and activator of transcription 6 as well as frequent mitosis. The mass was diagnosed as a grade 3 solitary fibrous tumor (SFT)/hemangiopericytoma (HPC). The cytological diagnosis of SFT/HPC is challenging because of the heterogeneous cytological findings, such as histological heterogeneity, and because there are no standardized cytological criteria for malignant SFT/HPC. Cytological findings, such as singly scattered small cells, hypercellularity, rare ropy collagen, and round and rhabdoid cells with pseudoalveolar pattern, may assist in the diagnosis of malignant SFT/HPC.http://www.jpatholtm.org/upload/pdf/jptm-2019-03-20.pdfSolitary fibrous tumorsHemangiopericytomaFrozenCytologyCentral nervous system |
| spellingShingle | Myunghee Kang Na Rae Kim Dong Hae Chung Gie-Taek Yie Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma Journal of Pathology and Translational Medicine Solitary fibrous tumors Hemangiopericytoma Frozen Cytology Central nervous system |
| title | Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma |
| title_full | Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma |
| title_fullStr | Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma |
| title_full_unstemmed | Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma |
| title_short | Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma |
| title_sort | frozen cytology of meningeal malignant solitary fibrous tumor hemangiopericytoma |
| topic | Solitary fibrous tumors Hemangiopericytoma Frozen Cytology Central nervous system |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2019-03-20.pdf |
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