Adipose afferent reflex is enhanced by TNFα in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats

Adipose afferent reflex is enhanced by TNFα in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats

Abstract Background The adipose afferent reflex (AAR), a sympatho-excitatory reflex, can promote the elevation of sympathetic nerve activity (SNA) and blood pressure (BP). Inflammation in the paraventricular nucleus (PVN) involves sympathetic abnormality in some cardiovascular diseases such as hyper...

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Bibliographic Details
Main Authors: Lei Ding, Ying Kang, Hang-Bing Dai, Fang-Zheng Wang, Hong Zhou, Qing Gao, Xiao-Qing Xiong, Feng Zhang, Tian-Run Song, Yan Yuan, Ming Liu, Guo-Qing Zhu, Ye-Bo Zhou
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Translational Medicine
Subjects:
Adipose afferent reflex
TNFα
Paraventricular nucleus
Sympathoexcitation
Obesity
Reactive oxygen species
Online Access:http://link.springer.com/article/10.1186/s12967-019-2006-0

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