Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment?
Tumour metabolism has gradually come to be regarded as a key target to prevent tumour growth and metastasis. The unique metabolic characteristics of tumours enable them to maintain self-proliferation in abnormal environments. In recent years, the necessity of hypoxia in the tumour microenvironment h...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222013063 |
| _version_ | 1811308640324288512 |
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| author | Bing Liang Lin Deng Xiuhua Zhou |
| author_facet | Bing Liang Lin Deng Xiuhua Zhou |
| author_sort | Bing Liang |
| collection | DOAJ |
| description | Tumour metabolism has gradually come to be regarded as a key target to prevent tumour growth and metastasis. The unique metabolic characteristics of tumours enable them to maintain self-proliferation in abnormal environments. In recent years, the necessity of hypoxia in the tumour microenvironment has been gradually recognized, and hypoxia-induced tumour metabolites are also regarded as key therapeutic targets. How these hypoxia-related metabolites support tumour development, how to regulate the malignant process of tumours, and how to prevent tumour immune escape have become urgent problems that need to be solved. In this review, we summarize the characteristic tumour regulation of hypoxia-related metabolites and the mechanisms that promote immune escape of tumours. Finally, we summarize the relevant targeted inhibitors in an attempt to provide some novel therapeutic insights. |
| first_indexed | 2024-04-13T09:26:53Z |
| format | Article |
| id | doaj.art-96e58b0cc9254563b0844d0ed850c08a |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-13T09:26:53Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-96e58b0cc9254563b0844d0ed850c08a2022-12-22T02:52:25ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-12-01156113917Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment?Bing Liang0Lin Deng1Xiuhua Zhou2Department of Critical Care Medicine, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Endocrinology, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Critical Care Medicine, The Fourth Affiliated Hospital of China Medical University, Shenyang, China; Corresponding author.Tumour metabolism has gradually come to be regarded as a key target to prevent tumour growth and metastasis. The unique metabolic characteristics of tumours enable them to maintain self-proliferation in abnormal environments. In recent years, the necessity of hypoxia in the tumour microenvironment has been gradually recognized, and hypoxia-induced tumour metabolites are also regarded as key therapeutic targets. How these hypoxia-related metabolites support tumour development, how to regulate the malignant process of tumours, and how to prevent tumour immune escape have become urgent problems that need to be solved. In this review, we summarize the characteristic tumour regulation of hypoxia-related metabolites and the mechanisms that promote immune escape of tumours. Finally, we summarize the relevant targeted inhibitors in an attempt to provide some novel therapeutic insights.http://www.sciencedirect.com/science/article/pii/S0753332222013063HypoxiaClinical treatmentImmuneMetabolism |
| spellingShingle | Bing Liang Lin Deng Xiuhua Zhou Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment? Biomedicine & Pharmacotherapy Hypoxia Clinical treatment Immune Metabolism |
| title | Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment? |
| title_full | Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment? |
| title_fullStr | Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment? |
| title_full_unstemmed | Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment? |
| title_short | Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment? |
| title_sort | targeting hypoxia related metabolism molecules how to improve tumour immune and clinical treatment |
| topic | Hypoxia Clinical treatment Immune Metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222013063 |
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