Non-alcoholic fatty liver disease and dairy products consumption: Results from FASA Persian cohort study
Background/objectivesThere are limited data on the association between dairy products consumption and nonalcoholic fatty liver disease (NAFLD). This study was conducted to evaluate the association between total intake of different dairy products and fatty liver index (FLI), a marker of subclinical f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.962834/full |
| _version_ | 1811274294739599360 |
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| author | Zahra Keshavarz Mehran Rahimlou Mojtaba Farjam Reza Homayounfar Mahmoud Khodadost Ashkan Abdollahi Reza Tabrizi Reza Tabrizi |
| author_facet | Zahra Keshavarz Mehran Rahimlou Mojtaba Farjam Reza Homayounfar Mahmoud Khodadost Ashkan Abdollahi Reza Tabrizi Reza Tabrizi |
| author_sort | Zahra Keshavarz |
| collection | DOAJ |
| description | Background/objectivesThere are limited data on the association between dairy products consumption and nonalcoholic fatty liver disease (NAFLD). This study was conducted to evaluate the association between total intake of different dairy products and fatty liver index (FLI), a marker of subclinical fatty liver.MethodsA total of 7,540 adults were included in this population-based cohort study. Dairy products consumption was evaluated by a validated interview questionnaire for food intake frequency. The FLI was calculated using the standard formula. Liver enzyme levels, lipid profiles, glycemic profiles and demographic characteristics were recorded for all participants. Univariate and multiple logistic regression models were used to respectively assess the mean percentage difference of mean FLI and odds ratios (ORs) for subclinical NAFLD across quantiles of dairy consumption.ResultsThe mean age of all participants was 48.81 ± 9.631 years. FLI measurements for men and women were 26.71 ± 23.39 and 39.99 ± 26.64 respectively, which was significantly higher in women (P < 0.05). Multiple logistic regression analysis demonstrated that the amount of milk consumption was an independent preventive predictor of FLI (OR = 0.96; 95% CI: 0.94–0.99), conversely, it did not predict higher levels of liver enzymes. In term of cheese intake, participants in the third tertile of cheese intake had significantly lower FLI than lower tertiles (P = 0.01). However, there wasn't any significant association between cheese intake and the odds of FLI in the multivariate model (P > 0.05). We didn't find any significant association between yogurt consumption and NAFLD indicators (P > 0.05).ConclusionHigher milk consumption was inversely associated with FLI. However, there wasn't any significant association between other types of dairy products and NAFLD indicators. |
| first_indexed | 2024-04-12T23:16:24Z |
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| id | doaj.art-96e5fa8983bf4dba8b2295f6fdc60624 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T23:16:24Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-96e5fa8983bf4dba8b2295f6fdc606242022-12-22T03:12:40ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-09-01910.3389/fnut.2022.962834962834Non-alcoholic fatty liver disease and dairy products consumption: Results from FASA Persian cohort studyZahra Keshavarz0Mehran Rahimlou1Mojtaba Farjam2Reza Homayounfar3Mahmoud Khodadost4Ashkan Abdollahi5Reza Tabrizi6Reza Tabrizi7Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, IranDepartment of Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, IranNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, IranNational Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Public Health, School of Health, Larestan University of Medical Sciences, Larestan, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, IranHealth Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, IranBackground/objectivesThere are limited data on the association between dairy products consumption and nonalcoholic fatty liver disease (NAFLD). This study was conducted to evaluate the association between total intake of different dairy products and fatty liver index (FLI), a marker of subclinical fatty liver.MethodsA total of 7,540 adults were included in this population-based cohort study. Dairy products consumption was evaluated by a validated interview questionnaire for food intake frequency. The FLI was calculated using the standard formula. Liver enzyme levels, lipid profiles, glycemic profiles and demographic characteristics were recorded for all participants. Univariate and multiple logistic regression models were used to respectively assess the mean percentage difference of mean FLI and odds ratios (ORs) for subclinical NAFLD across quantiles of dairy consumption.ResultsThe mean age of all participants was 48.81 ± 9.631 years. FLI measurements for men and women were 26.71 ± 23.39 and 39.99 ± 26.64 respectively, which was significantly higher in women (P < 0.05). Multiple logistic regression analysis demonstrated that the amount of milk consumption was an independent preventive predictor of FLI (OR = 0.96; 95% CI: 0.94–0.99), conversely, it did not predict higher levels of liver enzymes. In term of cheese intake, participants in the third tertile of cheese intake had significantly lower FLI than lower tertiles (P = 0.01). However, there wasn't any significant association between cheese intake and the odds of FLI in the multivariate model (P > 0.05). We didn't find any significant association between yogurt consumption and NAFLD indicators (P > 0.05).ConclusionHigher milk consumption was inversely associated with FLI. However, there wasn't any significant association between other types of dairy products and NAFLD indicators.https://www.frontiersin.org/articles/10.3389/fnut.2022.962834/fullnonalcoholic fatty liver diseasesdairyyogurtcheesecohort |
| spellingShingle | Zahra Keshavarz Mehran Rahimlou Mojtaba Farjam Reza Homayounfar Mahmoud Khodadost Ashkan Abdollahi Reza Tabrizi Reza Tabrizi Non-alcoholic fatty liver disease and dairy products consumption: Results from FASA Persian cohort study Frontiers in Nutrition nonalcoholic fatty liver diseases dairy yogurt cheese cohort |
| title | Non-alcoholic fatty liver disease and dairy products consumption: Results from FASA Persian cohort study |
| title_full | Non-alcoholic fatty liver disease and dairy products consumption: Results from FASA Persian cohort study |
| title_fullStr | Non-alcoholic fatty liver disease and dairy products consumption: Results from FASA Persian cohort study |
| title_full_unstemmed | Non-alcoholic fatty liver disease and dairy products consumption: Results from FASA Persian cohort study |
| title_short | Non-alcoholic fatty liver disease and dairy products consumption: Results from FASA Persian cohort study |
| title_sort | non alcoholic fatty liver disease and dairy products consumption results from fasa persian cohort study |
| topic | nonalcoholic fatty liver diseases dairy yogurt cheese cohort |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.962834/full |
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