Correlations between circulating methylmalonic acid levels and all-cause and cause-specific mortality among patients with diabetes
AimsEvidence regarding serum methylmalonic acid (MMA) levels and mortality in individuals with diabetes is limited. This study aimed to evaluate the correlation between MMA and all-cause and cause-specific deaths in patients with diabetes.Materials and methodsThis is a population-based cohort study...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-11-01
|
Series: | Frontiers in Nutrition |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.974938/full |
_version_ | 1811215724633391104 |
---|---|
author | Jiao Wang Jiao Wang Jiao Wang Yunliang Tang Ying Liu Ying Liu Ying Liu Wei Cai Jixiong Xu Jixiong Xu Jixiong Xu |
author_facet | Jiao Wang Jiao Wang Jiao Wang Yunliang Tang Ying Liu Ying Liu Ying Liu Wei Cai Jixiong Xu Jixiong Xu Jixiong Xu |
author_sort | Jiao Wang |
collection | DOAJ |
description | AimsEvidence regarding serum methylmalonic acid (MMA) levels and mortality in individuals with diabetes is limited. This study aimed to evaluate the correlation between MMA and all-cause and cause-specific deaths in patients with diabetes.Materials and methodsThis is a population-based cohort study based on data from both the National Health and Nutrition Examination Survey (NHANES) and National Death Index from 1999 to 2014. We assessed the association of serum MMA concentrations with mortality using Cox proportional hazard models after adjusting for lifestyle, demographic factors, and comorbidities.ResultsAmong the 3,097 participants, 843 mortalities occurred during a median follow-up of 4.42 years. There were 242 deaths due to cardiovascular disease (CVD) and 131 cancer-associated deaths. After multivariate adjustment, elevated serum MMA levels were markedly correlated with a high risk of all-cause, CVD-, and cancer-related deaths. Each one-unit increase in the natural log-transformed MMA level correlated with increased risk of all-cause mortality (2.652 times), CVD mortality risk (3.153 times), and cancer-related mortality risk (4.514). Hazard ratios (95% confidence intervals [CIs]) after comparing participants with MMA < 120 and ≥250 nmol/L were 2.177 (1.421–3.336) for all-cause mortality, 3.560 (1.809–7.004) for CVD mortality, and 4.244 (1.537–11.721) for cancer mortality.ConclusionHigher serum MMA levels were significantly associated with higher all-cause, CVD, and cancer mortality. These findings suggest that maintaining lower MMA status may lower mortality risk in individuals with diabetes. |
first_indexed | 2024-04-12T06:27:07Z |
format | Article |
id | doaj.art-96e60128a64f4f13b2539def897e3efe |
institution | Directory Open Access Journal |
issn | 2296-861X |
language | English |
last_indexed | 2024-04-12T06:27:07Z |
publishDate | 2022-11-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Nutrition |
spelling | doaj.art-96e60128a64f4f13b2539def897e3efe2022-12-22T03:44:06ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-11-01910.3389/fnut.2022.974938974938Correlations between circulating methylmalonic acid levels and all-cause and cause-specific mortality among patients with diabetesJiao Wang0Jiao Wang1Jiao Wang2Yunliang Tang3Ying Liu4Ying Liu5Ying Liu6Wei Cai7Jixiong Xu8Jixiong Xu9Jixiong Xu10Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, ChinaJiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, ChinaJiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, ChinaDepartment of Medical Genetics and Cell Biology, Medical College of Nanchang University, Nanchang, ChinaDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, ChinaJiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, ChinaAimsEvidence regarding serum methylmalonic acid (MMA) levels and mortality in individuals with diabetes is limited. This study aimed to evaluate the correlation between MMA and all-cause and cause-specific deaths in patients with diabetes.Materials and methodsThis is a population-based cohort study based on data from both the National Health and Nutrition Examination Survey (NHANES) and National Death Index from 1999 to 2014. We assessed the association of serum MMA concentrations with mortality using Cox proportional hazard models after adjusting for lifestyle, demographic factors, and comorbidities.ResultsAmong the 3,097 participants, 843 mortalities occurred during a median follow-up of 4.42 years. There were 242 deaths due to cardiovascular disease (CVD) and 131 cancer-associated deaths. After multivariate adjustment, elevated serum MMA levels were markedly correlated with a high risk of all-cause, CVD-, and cancer-related deaths. Each one-unit increase in the natural log-transformed MMA level correlated with increased risk of all-cause mortality (2.652 times), CVD mortality risk (3.153 times), and cancer-related mortality risk (4.514). Hazard ratios (95% confidence intervals [CIs]) after comparing participants with MMA < 120 and ≥250 nmol/L were 2.177 (1.421–3.336) for all-cause mortality, 3.560 (1.809–7.004) for CVD mortality, and 4.244 (1.537–11.721) for cancer mortality.ConclusionHigher serum MMA levels were significantly associated with higher all-cause, CVD, and cancer mortality. These findings suggest that maintaining lower MMA status may lower mortality risk in individuals with diabetes.https://www.frontiersin.org/articles/10.3389/fnut.2022.974938/fulldiabetesmortalitycardiovascular diseasescancerbiomarkers |
spellingShingle | Jiao Wang Jiao Wang Jiao Wang Yunliang Tang Ying Liu Ying Liu Ying Liu Wei Cai Jixiong Xu Jixiong Xu Jixiong Xu Correlations between circulating methylmalonic acid levels and all-cause and cause-specific mortality among patients with diabetes Frontiers in Nutrition diabetes mortality cardiovascular diseases cancer biomarkers |
title | Correlations between circulating methylmalonic acid levels and all-cause and cause-specific mortality among patients with diabetes |
title_full | Correlations between circulating methylmalonic acid levels and all-cause and cause-specific mortality among patients with diabetes |
title_fullStr | Correlations between circulating methylmalonic acid levels and all-cause and cause-specific mortality among patients with diabetes |
title_full_unstemmed | Correlations between circulating methylmalonic acid levels and all-cause and cause-specific mortality among patients with diabetes |
title_short | Correlations between circulating methylmalonic acid levels and all-cause and cause-specific mortality among patients with diabetes |
title_sort | correlations between circulating methylmalonic acid levels and all cause and cause specific mortality among patients with diabetes |
topic | diabetes mortality cardiovascular diseases cancer biomarkers |
url | https://www.frontiersin.org/articles/10.3389/fnut.2022.974938/full |
work_keys_str_mv | AT jiaowang correlationsbetweencirculatingmethylmalonicacidlevelsandallcauseandcausespecificmortalityamongpatientswithdiabetes AT jiaowang correlationsbetweencirculatingmethylmalonicacidlevelsandallcauseandcausespecificmortalityamongpatientswithdiabetes AT jiaowang correlationsbetweencirculatingmethylmalonicacidlevelsandallcauseandcausespecificmortalityamongpatientswithdiabetes AT yunliangtang correlationsbetweencirculatingmethylmalonicacidlevelsandallcauseandcausespecificmortalityamongpatientswithdiabetes AT yingliu correlationsbetweencirculatingmethylmalonicacidlevelsandallcauseandcausespecificmortalityamongpatientswithdiabetes AT yingliu correlationsbetweencirculatingmethylmalonicacidlevelsandallcauseandcausespecificmortalityamongpatientswithdiabetes AT yingliu correlationsbetweencirculatingmethylmalonicacidlevelsandallcauseandcausespecificmortalityamongpatientswithdiabetes AT weicai correlationsbetweencirculatingmethylmalonicacidlevelsandallcauseandcausespecificmortalityamongpatientswithdiabetes AT jixiongxu correlationsbetweencirculatingmethylmalonicacidlevelsandallcauseandcausespecificmortalityamongpatientswithdiabetes AT jixiongxu correlationsbetweencirculatingmethylmalonicacidlevelsandallcauseandcausespecificmortalityamongpatientswithdiabetes AT jixiongxu correlationsbetweencirculatingmethylmalonicacidlevelsandallcauseandcausespecificmortalityamongpatientswithdiabetes |