A Case of Cutaneous Vasculitis in the Setting of Systemic Lupus Erythematosus and Cocaine Use
Cocaine, one of most prevalent illicit substances in the United States, affects a multitude of organ systems and precedes numerous negative health outcomes. Many of the consequences of cocaine are linked to induction of vasoconstriction. For this reason, cocaine users are placed at considerable risk...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-05-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/23247096231176215 |
| _version_ | 1797823227004715008 |
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| author | Chad M. Jaenke BS Sara R. Moore PhD Matthew D. Miller BA Anu Garg MD |
| author_facet | Chad M. Jaenke BS Sara R. Moore PhD Matthew D. Miller BA Anu Garg MD |
| author_sort | Chad M. Jaenke BS |
| collection | DOAJ |
| description | Cocaine, one of most prevalent illicit substances in the United States, affects a multitude of organ systems and precedes numerous negative health outcomes. Many of the consequences of cocaine are linked to induction of vasoconstriction. For this reason, cocaine users are placed at considerable risk of ischemic stroke, myocardial infarction, and cardiac arrhythmias. Furthermore, a prominent contaminant, levamisole, has been widely implicated in predisposing individuals to developing or exacerbating cutaneous vasculitides. This report details a 31-year-old woman with acute, localized necrotic skin lesions after cocaine use. Her clinical picture was complicated by a 17-year history of systemic lupus erythematosus (SLE) and Raynaud’s phenomenon. This case examines the challenge of forming a differential diagnosis, initiating an appropriate workup, and interpreting serologic-based and immunologic-based studies to differentiate between SLE and drug-based etiologies of skin necrosis. Finally, we discuss appropriate treatment plans to mitigate symptoms and reduce future instances of drug-induced vasculitis. |
| first_indexed | 2024-03-13T10:20:54Z |
| format | Article |
| id | doaj.art-96e619aaf2e3496aa5301da74c8f6c45 |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-03-13T10:20:54Z |
| publishDate | 2023-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-96e619aaf2e3496aa5301da74c8f6c452023-05-20T20:33:45ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962023-05-011110.1177/23247096231176215A Case of Cutaneous Vasculitis in the Setting of Systemic Lupus Erythematosus and Cocaine UseChad M. Jaenke BS0Sara R. Moore PhD1Matthew D. Miller BA2Anu Garg MD3The University of Toledo Medical Center, OH, USAThe University of Toledo Medical Center, OH, USAThe University of Toledo Medical Center, OH, USAThe University of Toledo Medical Center, OH, USACocaine, one of most prevalent illicit substances in the United States, affects a multitude of organ systems and precedes numerous negative health outcomes. Many of the consequences of cocaine are linked to induction of vasoconstriction. For this reason, cocaine users are placed at considerable risk of ischemic stroke, myocardial infarction, and cardiac arrhythmias. Furthermore, a prominent contaminant, levamisole, has been widely implicated in predisposing individuals to developing or exacerbating cutaneous vasculitides. This report details a 31-year-old woman with acute, localized necrotic skin lesions after cocaine use. Her clinical picture was complicated by a 17-year history of systemic lupus erythematosus (SLE) and Raynaud’s phenomenon. This case examines the challenge of forming a differential diagnosis, initiating an appropriate workup, and interpreting serologic-based and immunologic-based studies to differentiate between SLE and drug-based etiologies of skin necrosis. Finally, we discuss appropriate treatment plans to mitigate symptoms and reduce future instances of drug-induced vasculitis.https://doi.org/10.1177/23247096231176215 |
| spellingShingle | Chad M. Jaenke BS Sara R. Moore PhD Matthew D. Miller BA Anu Garg MD A Case of Cutaneous Vasculitis in the Setting of Systemic Lupus Erythematosus and Cocaine Use Journal of Investigative Medicine High Impact Case Reports |
| title | A Case of Cutaneous Vasculitis in the Setting of Systemic Lupus Erythematosus and Cocaine Use |
| title_full | A Case of Cutaneous Vasculitis in the Setting of Systemic Lupus Erythematosus and Cocaine Use |
| title_fullStr | A Case of Cutaneous Vasculitis in the Setting of Systemic Lupus Erythematosus and Cocaine Use |
| title_full_unstemmed | A Case of Cutaneous Vasculitis in the Setting of Systemic Lupus Erythematosus and Cocaine Use |
| title_short | A Case of Cutaneous Vasculitis in the Setting of Systemic Lupus Erythematosus and Cocaine Use |
| title_sort | case of cutaneous vasculitis in the setting of systemic lupus erythematosus and cocaine use |
| url | https://doi.org/10.1177/23247096231176215 |
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