Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization
The cyclopropylthiophene moiety has attracted the attention of the scientific community for its potential pharmaceutical applications. However, synthesis of the compounds containing this framework remains challenging, has rarely been reported and remains unresolved. Here we provide optimized synthes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/9/3770 |
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| author | Tomas Paškevičius Ringailė Lapinskaitė Sigitas Stončius Rita Sadzevičienė Asta Judžentienė Linas Labanauskas |
| author_facet | Tomas Paškevičius Ringailė Lapinskaitė Sigitas Stončius Rita Sadzevičienė Asta Judžentienė Linas Labanauskas |
| author_sort | Tomas Paškevičius |
| collection | DOAJ |
| description | The cyclopropylthiophene moiety has attracted the attention of the scientific community for its potential pharmaceutical applications. However, synthesis of the compounds containing this framework remains challenging, has rarely been reported and remains unresolved. Here we provide optimized syntheses for cyclopropylthiophenes and their derivatives, containing carbonyl, acetyl, carboxylic acid, methyl carboxylate, nitrile, bromide and sulfonyl chloride moieties. |
| first_indexed | 2024-03-11T04:12:20Z |
| format | Article |
| id | doaj.art-96ec3f69abeb497487ac88cbbab56e82 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:12:20Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-96ec3f69abeb497487ac88cbbab56e822023-11-17T23:23:12ZengMDPI AGMolecules1420-30492023-04-01289377010.3390/molecules28093770Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their DerivatizationTomas Paškevičius0Ringailė Lapinskaitė1Sigitas Stončius2Rita Sadzevičienė3Asta Judžentienė4Linas Labanauskas5Department of Organic Chemistry, Center for Physical Sciences and Technology (FTMC), Akademijos g. 7, LT-08412 Vilnius, LithuaniaDepartment of Organic Chemistry, Center for Physical Sciences and Technology (FTMC), Akademijos g. 7, LT-08412 Vilnius, LithuaniaDepartment of Organic Chemistry, Center for Physical Sciences and Technology (FTMC), Akademijos g. 7, LT-08412 Vilnius, LithuaniaDepartment of Organic Chemistry, Center for Physical Sciences and Technology (FTMC), Akademijos g. 7, LT-08412 Vilnius, LithuaniaDepartment of Organic Chemistry, Center for Physical Sciences and Technology (FTMC), Akademijos g. 7, LT-08412 Vilnius, LithuaniaDepartment of Organic Chemistry, Center for Physical Sciences and Technology (FTMC), Akademijos g. 7, LT-08412 Vilnius, LithuaniaThe cyclopropylthiophene moiety has attracted the attention of the scientific community for its potential pharmaceutical applications. However, synthesis of the compounds containing this framework remains challenging, has rarely been reported and remains unresolved. Here we provide optimized syntheses for cyclopropylthiophenes and their derivatives, containing carbonyl, acetyl, carboxylic acid, methyl carboxylate, nitrile, bromide and sulfonyl chloride moieties.https://www.mdpi.com/1420-3049/28/9/3770thiophenecyclopropylthiopheneSuzuki–Miyaura cross couplingcatalysis |
| spellingShingle | Tomas Paškevičius Ringailė Lapinskaitė Sigitas Stončius Rita Sadzevičienė Asta Judžentienė Linas Labanauskas Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization Molecules thiophene cyclopropylthiophene Suzuki–Miyaura cross coupling catalysis |
| title | Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization |
| title_full | Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization |
| title_fullStr | Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization |
| title_full_unstemmed | Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization |
| title_short | Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization |
| title_sort | palladium catalyzed synthesis of cyclopropylthiophenes and their derivatization |
| topic | thiophene cyclopropylthiophene Suzuki–Miyaura cross coupling catalysis |
| url | https://www.mdpi.com/1420-3049/28/9/3770 |
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