Application of Physiologically Based Absorption Modeling to Characterize the Pharmacokinetic Profiles of Oral Extended Release Methylphenidate Products in Adults.

Application of Physiologically Based Absorption Modeling to Characterize the Pharmacokinetic Profiles of Oral Extended Release Methylphenidate Products in Adults.

A previously presented physiologically-based pharmacokinetic model for immediate release (IR) methylphenidate (MPH) was extended to characterize the pharmacokinetic behaviors of oral extended release (ER) MPH formulations in adults for the first time. Information on the anatomy and physiology of the...

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Bibliografiske detaljer
Main Authors:	Xiaoxia Yang, John Duan, Jeffrey Fisher
Format:	Article
Sprog:	English
Udgivet:	Public Library of Science (PLoS) 2016-01-01
Serier:	PLoS ONE
Online adgang:	http://europepmc.org/articles/PMC5056674?pdf=render

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