Impaired Sacculocollic Reflex in Lateral Medullary Infarction
Objective: The aim of this study was to determine saccular dysfunction by measuring cervical vestibular-evoked myogenic potentials (cVEMP) and to correlate abnormality of cVEMP with results of other vestibular function tests in lateral medullary infarction (LMI). Methods: We recorded cVEMP in 21 pat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2011.00008/full |
| _version_ | 1828514881959100416 |
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| author | Seonhye eKim Hyo-Jung eKim Ji Soo eKim |
| author_facet | Seonhye eKim Hyo-Jung eKim Ji Soo eKim |
| author_sort | Seonhye eKim |
| collection | DOAJ |
| description | Objective: The aim of this study was to determine saccular dysfunction by measuring cervical vestibular-evoked myogenic potentials (cVEMP) and to correlate abnormality of cVEMP with results of other vestibular function tests in lateral medullary infarction (LMI). Methods: We recorded cVEMP in 21 patients with LMI documented on MRI. cVEMP was induced by a short tone burst and was recorded in contracting sternocleidomastoid muscle while patients turned their heads forcefully to the contralateral side against resistance. Patients also underwent video-oculographic recording of spontaneous, gaze-evoked and head-shaking (HSN) nystagmus, evaluation of ocular tilt reaction (OTR), measurement of the subjective visual vertical (SVV) tilt, bithermal caloric tests and audiometry. Results: Nine patients (43%) showed abnormal cVEMP, unilateral in seven and bilateral in two. The cVEMP abnormalities included decreased p13-n23 amplitude in four, delayed p13/n23 responses in five, and both decreased and delayed responses in two. The abnormal cVEMP was ipsilesional in five, contralesional in two, and bilateral in two. The prevalence of OTR/SVV tilt, spontaneous nystagmus, and HSN did not differ between the patients with normal and abnormal cVEMP. Conclusion: cVEMP was abnormal in approximately half of the patients with LMI. The abnormal cVEMP indicates damage to the descending sacculocollic reflex pathway or disruption of commissural modulation between the vestibular nuclei. |
| first_indexed | 2024-12-11T18:05:57Z |
| format | Article |
| id | doaj.art-96f02997234f4bcabaa562809b9c9ada |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T18:05:57Z |
| publishDate | 2011-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-96f02997234f4bcabaa562809b9c9ada2022-12-22T00:55:44ZengFrontiers Media S.A.Frontiers in Neurology1664-22952011-02-01210.3389/fneur.2011.000087805Impaired Sacculocollic Reflex in Lateral Medullary InfarctionSeonhye eKim0Hyo-Jung eKim1Ji Soo eKim2Pusan National University Yangsan HospitalSeoul National University Bundang HospitalSeoul National University Bundang HospitalObjective: The aim of this study was to determine saccular dysfunction by measuring cervical vestibular-evoked myogenic potentials (cVEMP) and to correlate abnormality of cVEMP with results of other vestibular function tests in lateral medullary infarction (LMI). Methods: We recorded cVEMP in 21 patients with LMI documented on MRI. cVEMP was induced by a short tone burst and was recorded in contracting sternocleidomastoid muscle while patients turned their heads forcefully to the contralateral side against resistance. Patients also underwent video-oculographic recording of spontaneous, gaze-evoked and head-shaking (HSN) nystagmus, evaluation of ocular tilt reaction (OTR), measurement of the subjective visual vertical (SVV) tilt, bithermal caloric tests and audiometry. Results: Nine patients (43%) showed abnormal cVEMP, unilateral in seven and bilateral in two. The cVEMP abnormalities included decreased p13-n23 amplitude in four, delayed p13/n23 responses in five, and both decreased and delayed responses in two. The abnormal cVEMP was ipsilesional in five, contralesional in two, and bilateral in two. The prevalence of OTR/SVV tilt, spontaneous nystagmus, and HSN did not differ between the patients with normal and abnormal cVEMP. Conclusion: cVEMP was abnormal in approximately half of the patients with LMI. The abnormal cVEMP indicates damage to the descending sacculocollic reflex pathway or disruption of commissural modulation between the vestibular nuclei.http://journal.frontiersin.org/Journal/10.3389/fneur.2011.00008/fullVertigolateral medullary infarctionvestibular-evoked myogenic potentialWallenberg syndrome |
| spellingShingle | Seonhye eKim Hyo-Jung eKim Ji Soo eKim Impaired Sacculocollic Reflex in Lateral Medullary Infarction Frontiers in Neurology Vertigo lateral medullary infarction vestibular-evoked myogenic potential Wallenberg syndrome |
| title | Impaired Sacculocollic Reflex in Lateral Medullary Infarction |
| title_full | Impaired Sacculocollic Reflex in Lateral Medullary Infarction |
| title_fullStr | Impaired Sacculocollic Reflex in Lateral Medullary Infarction |
| title_full_unstemmed | Impaired Sacculocollic Reflex in Lateral Medullary Infarction |
| title_short | Impaired Sacculocollic Reflex in Lateral Medullary Infarction |
| title_sort | impaired sacculocollic reflex in lateral medullary infarction |
| topic | Vertigo lateral medullary infarction vestibular-evoked myogenic potential Wallenberg syndrome |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2011.00008/full |
| work_keys_str_mv | AT seonhyeekim impairedsacculocollicreflexinlateralmedullaryinfarction AT hyojungekim impairedsacculocollicreflexinlateralmedullaryinfarction AT jisooekim impairedsacculocollicreflexinlateralmedullaryinfarction |