Treatment of paroxysmal nocturnal hemoglobinuria in pregnancy with eculizumab: A case report
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease caused by mutations in hematopoietic stem cells leading to pancytopenia and a predisposition for thromboembolic events. In pregnancy, these manifestations can be amplified, leading to increased neonatal and maternal morbidity and mortality....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | Case Reports in Women's Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214911221000126 |
| _version_ | 1818449257626075136 |
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| author | Michael J. Fassett Adrian L. Hernandez Lopez |
| author_facet | Michael J. Fassett Adrian L. Hernandez Lopez |
| author_sort | Michael J. Fassett |
| collection | DOAJ |
| description | Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease caused by mutations in hematopoietic stem cells leading to pancytopenia and a predisposition for thromboembolic events. In pregnancy, these manifestations can be amplified, leading to increased neonatal and maternal morbidity and mortality. Although data are limited, eculizumab has emerged as a potential treatment of PNH in pregnancy. This report describes a case of a woman with PNH successfully treated with eculizumab during two pregnancies. Although during both pregnancies she experienced breakthrough hemolysis requiring intermittent blood transfusions, she had no thromboembolic events and had term vaginal births. Granted more research is needed, eculizumab may be an acceptable therapy for PNH in pregnancy. |
| first_indexed | 2024-12-14T20:32:32Z |
| format | Article |
| id | doaj.art-96f07a16310547c196d5f740e82e7293 |
| institution | Directory Open Access Journal |
| issn | 2214-9112 |
| language | English |
| last_indexed | 2024-12-14T20:32:32Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Case Reports in Women's Health |
| spelling | doaj.art-96f07a16310547c196d5f740e82e72932022-12-21T22:48:30ZengElsevierCase Reports in Women's Health2214-91122021-04-0130e00294Treatment of paroxysmal nocturnal hemoglobinuria in pregnancy with eculizumab: A case reportMichael J. Fassett0Adrian L. Hernandez Lopez1Department of Obstetrics and Gynecology, Kaiser Permanente Southern California, West Los Angeles Medical Center, 6041 Cadillac Ave 3rd Floor, Los Angeles, CA 90034, United States of America; Corresponding author.Department of Obstetrics and Gynecology, Kaiser Permanente Southern California, Los Angeles Medical Center, 4900 Sunset Blvd 5th Floor, Los Angeles, CA 90027, United States of AmericaParoxysmal nocturnal hemoglobinuria (PNH) is a rare disease caused by mutations in hematopoietic stem cells leading to pancytopenia and a predisposition for thromboembolic events. In pregnancy, these manifestations can be amplified, leading to increased neonatal and maternal morbidity and mortality. Although data are limited, eculizumab has emerged as a potential treatment of PNH in pregnancy. This report describes a case of a woman with PNH successfully treated with eculizumab during two pregnancies. Although during both pregnancies she experienced breakthrough hemolysis requiring intermittent blood transfusions, she had no thromboembolic events and had term vaginal births. Granted more research is needed, eculizumab may be an acceptable therapy for PNH in pregnancy.http://www.sciencedirect.com/science/article/pii/S2214911221000126EculizumabParoxysmal nocturnal hemoglobinuriaPregnancyHematology |
| spellingShingle | Michael J. Fassett Adrian L. Hernandez Lopez Treatment of paroxysmal nocturnal hemoglobinuria in pregnancy with eculizumab: A case report Case Reports in Women's Health Eculizumab Paroxysmal nocturnal hemoglobinuria Pregnancy Hematology |
| title | Treatment of paroxysmal nocturnal hemoglobinuria in pregnancy with eculizumab: A case report |
| title_full | Treatment of paroxysmal nocturnal hemoglobinuria in pregnancy with eculizumab: A case report |
| title_fullStr | Treatment of paroxysmal nocturnal hemoglobinuria in pregnancy with eculizumab: A case report |
| title_full_unstemmed | Treatment of paroxysmal nocturnal hemoglobinuria in pregnancy with eculizumab: A case report |
| title_short | Treatment of paroxysmal nocturnal hemoglobinuria in pregnancy with eculizumab: A case report |
| title_sort | treatment of paroxysmal nocturnal hemoglobinuria in pregnancy with eculizumab a case report |
| topic | Eculizumab Paroxysmal nocturnal hemoglobinuria Pregnancy Hematology |
| url | http://www.sciencedirect.com/science/article/pii/S2214911221000126 |
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