Trilobatin ameliorates HFD/STZ-induced glycolipid metabolism disorders through AMPK-mediated pathways
Lithocarpus polystachyus Rehd is a sweet tea passed down from the folklore of southern China and is said to be effective in emaciation-thirst disease, which traditional Chinese medicine considers as diabetes. In the present study, we purified the major dihydrochalcone compound trilobatin (TRI) from...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623000786 |
| _version_ | 1797869853477961728 |
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| author | Yu-te Zhong Qiong Shen Yu-ting Yang Ruo-bing Zhang Li-chun Zhao Wei Li |
| author_facet | Yu-te Zhong Qiong Shen Yu-ting Yang Ruo-bing Zhang Li-chun Zhao Wei Li |
| author_sort | Yu-te Zhong |
| collection | DOAJ |
| description | Lithocarpus polystachyus Rehd is a sweet tea passed down from the folklore of southern China and is said to be effective in emaciation-thirst disease, which traditional Chinese medicine considers as diabetes. In the present study, we purified the major dihydrochalcone compound trilobatin (TRI) from sweet tea. Besides, a high-fat diet (HFD) combined with streptozotocin (STZ) induced type 2 diabetic mice model was used to investigate the effect of TRI in preventing glycolipid metabolism disorder. According to the results, TRI administration provided some improvement in elevated blood lipids, liver function, fatty liver, glucose metabolism disorders, and insulin sensitivity. These results demonstrated that TRI suppresses glycolipid metabolism disorder. According to the western blotting results, TRI stimulates AMPK and ACC phosphorylation while inhibiting the production of PGC-1α, PCK1, and G6Pase. Thus, AMPK-mediated gluconeogenesis and fatty acid anabolism may be inhibited by TRI, which may be the mechanism that TRI ameliorates glycolipid metabolism disorder. |
| first_indexed | 2024-04-10T00:18:02Z |
| format | Article |
| id | doaj.art-96f3d12316c1401782bbcbb58263a5a6 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-10T00:18:02Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-96f3d12316c1401782bbcbb58263a5a62023-03-16T05:03:32ZengElsevierJournal of Functional Foods1756-46462023-04-01103105478Trilobatin ameliorates HFD/STZ-induced glycolipid metabolism disorders through AMPK-mediated pathwaysYu-te Zhong0Qiong Shen1Yu-ting Yang2Ruo-bing Zhang3Li-chun Zhao4Wei Li5College of Pharmacy, Guangxi University of Chinese Medicine, Wuhe Avenue #13, Nanning 530200, Guangxi, PR China; College of Chinese Medicinal Materials, Jilin Agricultural University, Xinchengdajie #2888, Changchun 130118, Jilin, PR ChinaCollege of Chinese Medicinal Materials, Jilin Agricultural University, Xinchengdajie #2888, Changchun 130118, Jilin, PR ChinaCollege of Pharmacy, Guangxi University of Chinese Medicine, Wuhe Avenue #13, Nanning 530200, Guangxi, PR China; Guangxi Zhuang Yao Medicine Center Engineering and Technology, Wuhe Avenue #13, Nanning 530200, Guangxi, PR ChinaCollege of Chinese Medicinal Materials, Jilin Agricultural University, Xinchengdajie #2888, Changchun 130118, Jilin, PR ChinaCollege of Pharmacy, Guangxi University of Chinese Medicine, Wuhe Avenue #13, Nanning 530200, Guangxi, PR China; Guangxi Zhuang Yao Medicine Center Engineering and Technology, Wuhe Avenue #13, Nanning 530200, Guangxi, PR China; Corresponding authors at: College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, 530200, PR China (L.-c. Zhao).College of Chinese Medicinal Materials, Jilin Agricultural University, Xinchengdajie #2888, Changchun 130118, Jilin, PR China; Corresponding authors at: College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, 530200, PR China (L.-c. Zhao).Lithocarpus polystachyus Rehd is a sweet tea passed down from the folklore of southern China and is said to be effective in emaciation-thirst disease, which traditional Chinese medicine considers as diabetes. In the present study, we purified the major dihydrochalcone compound trilobatin (TRI) from sweet tea. Besides, a high-fat diet (HFD) combined with streptozotocin (STZ) induced type 2 diabetic mice model was used to investigate the effect of TRI in preventing glycolipid metabolism disorder. According to the results, TRI administration provided some improvement in elevated blood lipids, liver function, fatty liver, glucose metabolism disorders, and insulin sensitivity. These results demonstrated that TRI suppresses glycolipid metabolism disorder. According to the western blotting results, TRI stimulates AMPK and ACC phosphorylation while inhibiting the production of PGC-1α, PCK1, and G6Pase. Thus, AMPK-mediated gluconeogenesis and fatty acid anabolism may be inhibited by TRI, which may be the mechanism that TRI ameliorates glycolipid metabolism disorder.http://www.sciencedirect.com/science/article/pii/S1756464623000786TrilobatinT2DMGlycolipid metabolism disorderAMPK |
| spellingShingle | Yu-te Zhong Qiong Shen Yu-ting Yang Ruo-bing Zhang Li-chun Zhao Wei Li Trilobatin ameliorates HFD/STZ-induced glycolipid metabolism disorders through AMPK-mediated pathways Journal of Functional Foods Trilobatin T2DM Glycolipid metabolism disorder AMPK |
| title | Trilobatin ameliorates HFD/STZ-induced glycolipid metabolism disorders through AMPK-mediated pathways |
| title_full | Trilobatin ameliorates HFD/STZ-induced glycolipid metabolism disorders through AMPK-mediated pathways |
| title_fullStr | Trilobatin ameliorates HFD/STZ-induced glycolipid metabolism disorders through AMPK-mediated pathways |
| title_full_unstemmed | Trilobatin ameliorates HFD/STZ-induced glycolipid metabolism disorders through AMPK-mediated pathways |
| title_short | Trilobatin ameliorates HFD/STZ-induced glycolipid metabolism disorders through AMPK-mediated pathways |
| title_sort | trilobatin ameliorates hfd stz induced glycolipid metabolism disorders through ampk mediated pathways |
| topic | Trilobatin T2DM Glycolipid metabolism disorder AMPK |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623000786 |
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