Asymmetry of the temporal code for space by hippocampal place cells
Abstract Hippocampal place cells convey spatial information through spike frequency (“rate coding”) and spike timing relative to the theta phase (“temporal coding”). Whether rate and temporal coding are due to independent or related mechanisms has been the subject of wide debate. Here we show that t...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-08609-3 |
| _version_ | 1818423183063121920 |
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| author | Bryan C. Souza Adriano B. L. Tort |
| author_facet | Bryan C. Souza Adriano B. L. Tort |
| author_sort | Bryan C. Souza |
| collection | DOAJ |
| description | Abstract Hippocampal place cells convey spatial information through spike frequency (“rate coding”) and spike timing relative to the theta phase (“temporal coding”). Whether rate and temporal coding are due to independent or related mechanisms has been the subject of wide debate. Here we show that the spike timing of place cells couples to theta phase before major increases in firing rate, anticipating the animal’s entrance into the classical, rate-based place field. In contrast, spikes rapidly decouple from theta as the animal leaves the place field and firing rate decreases. Therefore, temporal coding has strong asymmetry around the place field center. We further show that the dynamics of temporal coding along space evolves in three stages as the animal traverses the place field: phase coupling, sharp precession and phase decoupling. These results suggest that independent mechanisms may govern rate and temporal coding. |
| first_indexed | 2024-12-14T13:38:06Z |
| format | Article |
| id | doaj.art-96f7696c70f34aa2ba418a46bd4d97e0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T13:38:06Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-96f7696c70f34aa2ba418a46bd4d97e02022-12-21T22:59:31ZengNature PortfolioScientific Reports2045-23222017-08-01711910.1038/s41598-017-08609-3Asymmetry of the temporal code for space by hippocampal place cellsBryan C. Souza0Adriano B. L. Tort1Brain Institute, Federal University of Rio Grande do NorteBrain Institute, Federal University of Rio Grande do NorteAbstract Hippocampal place cells convey spatial information through spike frequency (“rate coding”) and spike timing relative to the theta phase (“temporal coding”). Whether rate and temporal coding are due to independent or related mechanisms has been the subject of wide debate. Here we show that the spike timing of place cells couples to theta phase before major increases in firing rate, anticipating the animal’s entrance into the classical, rate-based place field. In contrast, spikes rapidly decouple from theta as the animal leaves the place field and firing rate decreases. Therefore, temporal coding has strong asymmetry around the place field center. We further show that the dynamics of temporal coding along space evolves in three stages as the animal traverses the place field: phase coupling, sharp precession and phase decoupling. These results suggest that independent mechanisms may govern rate and temporal coding.https://doi.org/10.1038/s41598-017-08609-3 |
| spellingShingle | Bryan C. Souza Adriano B. L. Tort Asymmetry of the temporal code for space by hippocampal place cells Scientific Reports |
| title | Asymmetry of the temporal code for space by hippocampal place cells |
| title_full | Asymmetry of the temporal code for space by hippocampal place cells |
| title_fullStr | Asymmetry of the temporal code for space by hippocampal place cells |
| title_full_unstemmed | Asymmetry of the temporal code for space by hippocampal place cells |
| title_short | Asymmetry of the temporal code for space by hippocampal place cells |
| title_sort | asymmetry of the temporal code for space by hippocampal place cells |
| url | https://doi.org/10.1038/s41598-017-08609-3 |
| work_keys_str_mv | AT bryancsouza asymmetryofthetemporalcodeforspacebyhippocampalplacecells AT adrianobltort asymmetryofthetemporalcodeforspacebyhippocampalplacecells |