Complement System and Potential Therapeutics in Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is a complex multifactorial disease characterized in its late form by neovascularization (wet type) or geographic atrophy of the retinal pigment epithelium cell layer (dry type). The complement system is an intrinsic component of innate immunity. There has been...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/13/6851 |
| _version_ | 1797411973030215680 |
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| author | Young Gun Park Yong Soo Park In-Beom Kim |
| author_facet | Young Gun Park Yong Soo Park In-Beom Kim |
| author_sort | Young Gun Park |
| collection | DOAJ |
| description | Age-related macular degeneration (AMD) is a complex multifactorial disease characterized in its late form by neovascularization (wet type) or geographic atrophy of the retinal pigment epithelium cell layer (dry type). The complement system is an intrinsic component of innate immunity. There has been growing evidence that the complement system plays an integral role in maintaining immune surveillance and homeostasis in AMD. Based on the association between the genotypes of complement variants and AMD occurrence and the presence of complement in drusen from AMD patients, the complement system has become a therapeutic target for AMD. However, the mechanism of complement disease propagation in AMD has not been fully understood. This concise review focuses on an overall understanding of the role of the complement system in AMD and its ongoing clinical trials. It provides further insights into a strategy for the treatment of AMD targeting the complement system. |
| first_indexed | 2024-03-09T04:54:15Z |
| format | Article |
| id | doaj.art-96f7aa3de8914a2695f9e8e26d8f3ef1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:54:15Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-96f7aa3de8914a2695f9e8e26d8f3ef12023-12-03T13:07:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012213685110.3390/ijms22136851Complement System and Potential Therapeutics in Age-Related Macular DegenerationYoung Gun Park0Yong Soo Park1In-Beom Kim2Department of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaAge-related macular degeneration (AMD) is a complex multifactorial disease characterized in its late form by neovascularization (wet type) or geographic atrophy of the retinal pigment epithelium cell layer (dry type). The complement system is an intrinsic component of innate immunity. There has been growing evidence that the complement system plays an integral role in maintaining immune surveillance and homeostasis in AMD. Based on the association between the genotypes of complement variants and AMD occurrence and the presence of complement in drusen from AMD patients, the complement system has become a therapeutic target for AMD. However, the mechanism of complement disease propagation in AMD has not been fully understood. This concise review focuses on an overall understanding of the role of the complement system in AMD and its ongoing clinical trials. It provides further insights into a strategy for the treatment of AMD targeting the complement system.https://www.mdpi.com/1422-0067/22/13/6851age-related macular degenerationcomplement cascadeclinical trialtherapeutics |
| spellingShingle | Young Gun Park Yong Soo Park In-Beom Kim Complement System and Potential Therapeutics in Age-Related Macular Degeneration International Journal of Molecular Sciences age-related macular degeneration complement cascade clinical trial therapeutics |
| title | Complement System and Potential Therapeutics in Age-Related Macular Degeneration |
| title_full | Complement System and Potential Therapeutics in Age-Related Macular Degeneration |
| title_fullStr | Complement System and Potential Therapeutics in Age-Related Macular Degeneration |
| title_full_unstemmed | Complement System and Potential Therapeutics in Age-Related Macular Degeneration |
| title_short | Complement System and Potential Therapeutics in Age-Related Macular Degeneration |
| title_sort | complement system and potential therapeutics in age related macular degeneration |
| topic | age-related macular degeneration complement cascade clinical trial therapeutics |
| url | https://www.mdpi.com/1422-0067/22/13/6851 |
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