Long Noncoding RNA LINC00467: Role in Various Human Cancers
Intricate genetic mutations promote the progression of different cancer types. Long noncoding RNAs (lncRNAs) have been widely demonstrated to participate in the genomic activities of various human cancers. Long intergenic non-coding RNA 467 (LINC00467) is an upregulated lncRNA in diverse diseases, e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.892009/full |
| _version_ | 1818240280894111744 |
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| author | Di Wu Rongfei Li Jingyu Liu Changcheng Zhou Ruipeng Jia |
| author_facet | Di Wu Rongfei Li Jingyu Liu Changcheng Zhou Ruipeng Jia |
| author_sort | Di Wu |
| collection | DOAJ |
| description | Intricate genetic mutations promote the progression of different cancer types. Long noncoding RNAs (lncRNAs) have been widely demonstrated to participate in the genomic activities of various human cancers. Long intergenic non-coding RNA 467 (LINC00467) is an upregulated lncRNA in diverse diseases, especially in several types of cancers. Functional experiments of LINC00467 revealed that LINC00467 overexpression enhanced cell chemoresistance, proliferation, migration, and invasion in several types of cancers. Moreover, overexpressed LINC00467 was associated with a poor clinical prognosis. The present evidence suggests that LINC00467 may serve as a promising prognostic indicator and become a novel cancer therapeutic target. In this review, we introduce the biologic functions of lncRNAs and describe the molecular mechanism and clinical significance of LINC00467 in detail. |
| first_indexed | 2024-12-12T13:10:56Z |
| format | Article |
| id | doaj.art-96fa20d4d76e48f8bc7d116129aac448 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-12T13:10:56Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-96fa20d4d76e48f8bc7d116129aac4482022-12-22T00:23:32ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-06-011310.3389/fgene.2022.892009892009Long Noncoding RNA LINC00467: Role in Various Human CancersDi WuRongfei LiJingyu LiuChangcheng ZhouRuipeng JiaIntricate genetic mutations promote the progression of different cancer types. Long noncoding RNAs (lncRNAs) have been widely demonstrated to participate in the genomic activities of various human cancers. Long intergenic non-coding RNA 467 (LINC00467) is an upregulated lncRNA in diverse diseases, especially in several types of cancers. Functional experiments of LINC00467 revealed that LINC00467 overexpression enhanced cell chemoresistance, proliferation, migration, and invasion in several types of cancers. Moreover, overexpressed LINC00467 was associated with a poor clinical prognosis. The present evidence suggests that LINC00467 may serve as a promising prognostic indicator and become a novel cancer therapeutic target. In this review, we introduce the biologic functions of lncRNAs and describe the molecular mechanism and clinical significance of LINC00467 in detail.https://www.frontiersin.org/articles/10.3389/fgene.2022.892009/fullLINC00467microrna spongelong noncoding RNAscancersbiomarkerreview |
| spellingShingle | Di Wu Rongfei Li Jingyu Liu Changcheng Zhou Ruipeng Jia Long Noncoding RNA LINC00467: Role in Various Human Cancers Frontiers in Genetics LINC00467 microrna sponge long noncoding RNAs cancers biomarker review |
| title | Long Noncoding RNA LINC00467: Role in Various Human Cancers |
| title_full | Long Noncoding RNA LINC00467: Role in Various Human Cancers |
| title_fullStr | Long Noncoding RNA LINC00467: Role in Various Human Cancers |
| title_full_unstemmed | Long Noncoding RNA LINC00467: Role in Various Human Cancers |
| title_short | Long Noncoding RNA LINC00467: Role in Various Human Cancers |
| title_sort | long noncoding rna linc00467 role in various human cancers |
| topic | LINC00467 microrna sponge long noncoding RNAs cancers biomarker review |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.892009/full |
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